BMRB

Biological Magnetic Resonance Data Bank


A Repository for Data from NMR Spectroscopy on Proteins, Peptides, Nucleic Acids, and other Biomolecules
Member of WWPDB

BMRB Entry 2208

Title: 1H, 13C and 15N backbone assignments of cyclophilin when bound to cyclosporin A (CsA) and preliminary structural characterization of the CsA binding site

Authors: Neri, Placido; Meadows, Robert; Gemmecker, G.; Olejniczak, E.; Nettesheim, David; Logan, Timothy; Simmer, R.; Helfrich, R.; Holzman, Thomas; Severin, Jean; Fesik, Stephen

Citation: Neri, Placido; Meadows, Robert; Gemmecker, G.; Olejniczak, E.; Nettesheim, David; Logan, Timothy; Simmer, R.; Helfrich, R.; Holzman, Thomas; Severin, Jean; Fesik, Stephen. "1H, 13C and 15N backbone assignments of cyclophilin when bound to cyclosporin A (CsA) and preliminary structural characterization of the CsA binding site"  FEBS Lett. 294, 81-88 (1991).

Assembly members:
cyclophilin, polymer, 165 residues, Formula weight is not available

Natural source:   Common Name: human   Taxonomy ID: 9606   Superkingdom: Eukaryota   Kingdom: Metazoa   Genus/species: Homo sapiens

Experimental source:   Production method: not available   Host organism: Escherichia coli

Entity Sequences (FASTA):
cyclophilin: MVNPTVFFDIAVDGEPLGRV SFELFADKVPKTAENFRALS TGEKGFGYKGSCFHRIIPGF MCQGGDFTRHNGTGGKSIYG EKFEDENFILKHTGPGILSM ANAGPNTNGSQFFICTAKTE WLDGKHVVFGKVKEGMNIVE AMERFGSRNGKTSKKITIAD CGQLE

Data sets:
Data typeCount
13C chemical shifts318
15N chemical shifts156
1H chemical shifts323

Additional metadata:

  • Assembly
  • Samples and Experiments
  • Software
  • Spectrometers
  • Hide all

Assembly:

Entity Assembly IDEntity NameEntity ID
1cyclophilin1

Entities:

Entity 1, cyclophilin 165 residues - Formula weight is not available

1   METVALASNPROTHRVALPHEPHEASPILE
2   ALAVALASPGLYGLUPROLEUGLYARGVAL
3   SERPHEGLULEUPHEALAASPLYSVALPRO
4   LYSTHRALAGLUASNPHEARGALALEUSER
5   THRGLYGLULYSGLYPHEGLYTYRLYSGLY
6   SERCYSPHEHISARGILEILEPROGLYPHE
7   METCYSGLNGLYGLYASPPHETHRARGHIS
8   ASNGLYTHRGLYGLYLYSSERILETYRGLY
9   GLULYSPHEGLUASPGLUASNPHEILELEU
10   LYSHISTHRGLYPROGLYILELEUSERMET
11   ALAASNALAGLYPROASNTHRASNGLYSER
12   GLNPHEPHEILECYSTHRALALYSTHRGLU
13   TRPLEUASPGLYLYSHISVALVALPHEGLY
14   LYSVALLYSGLUGLYMETASNILEVALGLU
15   ALAMETGLUARGPHEGLYSERARGASNGLY
16   LYSTHRSERLYSLYSILETHRILEALAASP
17   CYSGLYGLNLEUGLU

Samples:

sample_one:

sample_condition_set_one: pH: 6.5 na; temperature: 293 K

Experiments:

NameSampleSample stateSample conditions
not availablesample_onenot availablesample_condition_set_one

Software:

No software information available

NMR spectrometers:

  • unknown unknown 0 MHz

Related Database Links:

BMRB 17218 25104 25337 25502
PDB
DBJ BAE01146 BAE30323 BAE87660 BAF82774 BAF83540
EMBL CAA34961 CAA37039 CAA68264 CAG32988 CAH91833
GB AAB81959 AAB81960 AAB81961 AAF69142 AAF78600
PIR CSHYAC
PRF 1503232A
REF NP_001009370 NP_001027981 NP_001126060 NP_001270275 NP_001271703
SP P14851 P62935 P62936 P62937 P62938
TPG DAA25853 DAA25854