BMRB

Biological Magnetic Resonance Data Bank


A Repository for Data from NMR Spectroscopy on Proteins, Peptides, Nucleic Acids, and other Biomolecules
Member of WWPDB

BMRB Entry 4938

Title: Two Different Neurodegenerative Diseases Caused by Proteins with Similiar Structures   PubMed: 11226243

Authors: Mo, Huaping; Moore, Richard; Cohen, Fred; Westway, David; Prusiner, Stanley; Wright, Peter; Dyson, H.

Citation: Mo, Huaping; Moore, Richard; Cohen, Fred; Westaway, David; Prusiner, Stanley; Wright, Peter; Dyson, H.. "Two Different Neurodegenerative Diseases Caused by Proteins with Similiar Structures"  Proc. Natl. Acad. Sci. U. S. A. 98, 2352-2357 (2001).

Assembly members:
mouse doppel, polymer, 132 residues, 15096 Da.

Natural source:   Common Name: mouse   Taxonomy ID: 10090   Superkingdom: Eukaryota   Kingdom: Metazoa   Genus/species: Mus musculus

Experimental source:   Production method: recombinant technology

Entity Sequences (FASTA):
mouse doppel: ARGIKHRFKWNRKVLPSSGG QITEARVAENRPGAFIKQGR KLDIDFGAEGNRYYAANYWQ FPDGIYYEGCSEANVTKEML VTSCVNATQAANQAEFSREK QDSKLHQRVLWRLIKEICSA KHCDFWLERGAA

Data sets:
Data typeCount
1H chemical shifts941
13C chemical shifts590
15N chemical shifts154

Additional metadata:

  • Assembly
  • Samples and Experiments
  • Software
  • Spectrometers
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Assembly:

Entity Assembly IDEntity NameEntity ID
1mdpl1

Entities:

Entity 1, mdpl 132 residues - 15096 Da.

1   ALAARGGLYILELYSHISARGPHELYSTRP
2   ASNARGLYSVALLEUPROSERSERGLYGLY
3   GLNILETHRGLUALAARGVALALAGLUASN
4   ARGPROGLYALAPHEILELYSGLNGLYARG
5   LYSLEUASPILEASPPHEGLYALAGLUGLY
6   ASNARGTYRTYRALAALAASNTYRTRPGLN
7   PHEPROASPGLYILETYRTYRGLUGLYCYS
8   SERGLUALAASNVALTHRLYSGLUMETLEU
9   VALTHRSERCYSVALASNALATHRGLNALA
10   ALAASNGLNALAGLUPHESERARGGLULYS
11   GLNASPSERLYSLEUHISGLNARGVALLEU
12   TRPARGLEUILELYSGLUILECYSSERALA
13   LYSHISCYSASPPHETRPLEUGLUARGGLY
14   ALAALA

Samples:

sample_1: mouse doppel, [U-15N], 3 mM

sample_2: mouse doppel, [U-15N; U-13N], 2 mM

ex-cond1: pH: 5.2; temperature: 299 K

Experiments:

NameSampleSample stateSample conditions

Software:

No software information available

NMR spectrometers:

  • Bruker Avance 600 MHz

Related Database Links:

PDB
DBJ BAC31436 BAE36166
GB AAD52000 AAF02544 AAF02545 AAF09196 AAF09197
REF NP_001119810 NP_001265186 NP_001265187 NP_001265188 NP_001265449
SP Q9QUG3