BMRB

Biological Magnetic Resonance Data Bank


A Repository for Data from NMR Spectroscopy on Proteins, Peptides, Nucleic Acids, and other Biomolecules
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BMRB Entry 5985

Title: Solution Conformation of alpha-Conotoxin GIC, a Novel Potent Antagonist of alpha3beta2 Nicotinic Acetylcholine Receptors   PubMed: 14992691

Authors: Chi, S.-W.; Kim, D.-H.; Olivera, B.; McIntosh, J.; Han, K.-H.

Citation: Chi, S.-W.; Kim, D.-H.; Olivera, B.; McIntosh, J.; Han, K.-H.. "Solution Conformation of alpha-Conotoxin GIC, a Novel Potent Antagonist of alpha3beta2 Nicotinic Acetylcholine Receptors "  Biochem. J. 380, 347-352 (2004).

Assembly members:
alpha-conotoxin GIC, polymer, 17 residues, Formula weight is not available

Natural source:   Common Name: Geography cone   Taxonomy ID: 6491   Superkingdom: Eukaryota   Kingdom: Metazoa   Genus/species: Conus geographus

Experimental source:   Production method: chemical synthesis

Entity Sequences (FASTA):
alpha-conotoxin GIC: GCCSHPACAGNNQHICX

Data sets:
Data typeCount
1H chemical shifts77
coupling constants13

Additional metadata:

  • Assembly
  • Samples and Experiments
  • Software
  • Spectrometers
  • Hide all

Assembly:

Entity Assembly IDEntity NameEntity ID
1alpha-conotoxin GIC1

Entities:

Entity 1, alpha-conotoxin GIC 17 residues - Formula weight is not available

1   GLYCYSCYSSERHISPROALACYSALAGLY
2   ASNASNGLNHISILECYSNH2

Samples:

sample_1: alpha-conotoxin GIC 11.5 mM

sample_cond_1: pH: 3.5; temperature: 293 K; ionic strength: 0 M; pressure: 1 atm

Experiments:

NameSampleSample stateSample conditions
2D NOESYsample_1not availablesample_cond_1
2D TOCSYsample_1not availablesample_cond_1
DQF-COSYsample_1not availablesample_cond_1

Software:

VNMR v6.1B - data collection

FELIX v98.0 - data processing

CNS v1.1 - structure refinement

NMR spectrometers:

  • Varian INOVA 600 MHz

Related Database Links:

PDB
GB AAO33169
SP Q86RB2