BMRB

Biological Magnetic Resonance Data Bank


A Repository for Data from NMR Spectroscopy on Proteins, Peptides, Nucleic Acids, and other Biomolecules
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BMRB Entry 4595

Title: Cystic fibrosis transmembrane conductance regulator: solution structures of peptides based on the Phe508 region, the most common site of disease-causing DeltaF508 mutation -- P25   PubMed: 10360942

Authors: Massiah, M.; Ko, Y.; Pedersen, P.; Mildvan, A.

Citation: Massiah, M.; Ko, Y.; Pedersen, P.; Mildvan, A.. "Cystic fibrosis transmembrane conductance regulator: solution structures of peptides based on the Phe508 region, the most common site of disease-causing DeltaF508 mutation"  Biochemistry 38, 7453-7461 (1999).

Assembly members:
protein (cystic fibrosis transmembrane conductance regulator (CFTR)), polymer, 25 residues, Formula weight is not available

Natural source:   Common Name: Human   Taxonomy ID: 9606   Superkingdom: Eucaryota   Kingdom: Metazoa   Genus/species: Homo sapiens

Experimental source:   Production method: chemical synthesis

Entity Sequences (FASTA):
protein (cystic fibrosis transmembrane conductance regulator (CFTR)): MPGTIKENIIGVSYDEYRYR SVIKA

Data sets:
Data typeCount
1H chemical shifts155

Additional metadata:

  • Assembly
  • Samples and Experiments
  • Software
  • Spectrometers
  • Hide all

Assembly:

Entity Assembly IDEntity NameEntity ID
1cystic fibrosis transmembrane conductance regulator (CFTR)1

Entities:

Entity 1, cystic fibrosis transmembrane conductance regulator (CFTR) 25 residues - Formula weight is not available

1   METPROGLYTHRILELYSGLUASNILEILE
2   GLYVALSERTYRASPGLUTYRARGTYRARG
3   SERVALILELYSALA

Samples:

sample_1: protein (cystic fibrosis transmembrane conductance regulator (CFTR)) 1.4 mM; Trifluroethanol 43%

sample_cond_1: pH: 4.0; temperature: 298 K; pressure: 1 atm

Experiments:

NameSampleSample stateSample conditions
NOESYsample_1not availablesample_cond_1
COSYsample_1not availablesample_cond_1
TOCSYsample_1not availablesample_cond_1

Software:

X-PLOR v3.8 - structure refinement

NMRVIEW2.1 - Structure solution

NMR spectrometers:

  • Varian UnityPlus 600 MHz

Related Database Links:

BMRB 25698 4598
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