BMRB

Biological Magnetic Resonance Data Bank


A Repository for Data from NMR Spectroscopy on Proteins, Peptides, Nucleic Acids, and other Biomolecules
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BMRB Entry 4598

Title: Cystic Fibrosis Transmembrane Conductance Regulator: Solution Structures of Peptides Based on the Phe508 Region, the Most Common Site of Disease-Causing DeltaF508 Mutation   PubMed: 10360942

Authors: Massiah, M.; Ko, Y.; Pedersen, P.; Mildvan, A.

Citation: Massiah, M.; Ko, Y.; Pedersen, P.; Mildvan, A.. "Cystic Fibrosis Transmembrane Conductance Regulator: Solution Structures of Peptides Based on the Phe508 Region, the Most Common Site of Disease-Causing DeltaF508 Mutation "  Biochemistry 38, 7453-7461 (1999).

Assembly members:
PROTEIN (CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR (CFTR)), polymer, 25 residues, Formula weight is not available

Natural source:   Common Name: Human   Taxonomy ID: 9606   Superkingdom: Eucaryota   Kingdom: Metazoa   Genus/species: Homo sapiens

Experimental source:   Production method: chemical synthesis

Entity Sequences (FASTA):
PROTEIN (CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR (CFTR)): MPGTIKENIIGVSYDEYRYR SVIKA

Data sets:
Data typeCount
1H chemical shifts151

Additional metadata:

  • Assembly
  • Samples and Experiments
  • Software
  • Spectrometers
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Assembly:

Entity Assembly IDEntity NameEntity ID
1cystic fibrosis transmembrane conductance regulator (CFTR)1

Entities:

Entity 1, cystic fibrosis transmembrane conductance regulator (CFTR) 25 residues - Formula weight is not available

1   METPROGLYTHRILELYSGLUASNILEILE
2   GLYVALSERTYRASPGLUTYRARGTYRARG
3   SERVALILELYSALA

Samples:

sample_1: PROTEIN (CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR (CFTR)) mM; H2O 90%; DMSO, [U-2H], 10%

sample_cond_1: pH: 4.0; temperature: 298 K; pressure: 1 atm

Experiments:

NameSampleSample stateSample conditions
NOESYsample_1not availablesample_cond_1
COSYsample_1not availablesample_cond_1
TOCSYsample_1not availablesample_cond_1

Software:

X-PLOR v3.8 - REFINEMENT

NMRVIEW2.1 - STRUCTURE SOLUTION

NMR spectrometers:

  • Varian UnityPlus 600 MHz

Related Database Links:

BMRB 25698 4595
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