Educational Outreach
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Dihydrofolate Reductase (DHFR) is a very important enzyme because
it produces cofactors that are necessary for DNA synthesis. Specifically, DHFR
catalyzes the reduction of folate and 7,8-dihydrofolate (DHF) to 5,6,7,8-tetrahydrofolate (THF).
THF is an essential cofactor involved in the the transfer of methyl, methylene, and
formyl groups from one molecule to another during the production of nucleotides and
several amino acids. An important example of this is the utilization of carbon units
from a THF cofactor by thymidylate synthase to make thymidine nucleotides.
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Information Related to NMR
Nobel Prizes awarded for developments that were key to NMR spectroscopy
- 1943 Otto Stern -
"for his contribution to the development of the molecular ray method and his discovery of the magnetic
moment of the proton"
- 1944 Isidor Isaac Rabi -
"for his resonance method for recording the magnetic properties of atomic nuclei"
- 1952 Felix Bloch and
Edward Mills Purcell - "for their development of new methods for nuclear magnetic precision measurements
and discoveries in connection therewith"
- 1991 Richard R. Ernst -
"for his contributions to the development of the methodology of high resolution nuclear magnetic resonance (NMR)
spectroscopy"
- 2002 Kurt Wüthrich -
"for his development of nuclear magnetic resonance spectroscopy for determining the three-dimensional structure of
biological macromolecules in solution"
- 2003
Paul C. Lauterbur and Sir Peter Mansfield -
"for their discoveries concerning magnetic resonance imaging"
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