data_16010 ####################### # Entry information # ####################### save_entry_information _Saveframe_category entry_information _Entry_title ; How do Proteins Form Amyloid? Insight from the NMR Spectroscopic Characterization of 13C, 15N-labeled Ribonuclease A in 40% Acetic Acid ; _BMRB_accession_number 16010 _BMRB_flat_file_name bmr16010.str _Entry_type original _Submission_date 2008-10-30 _Accession_date 2008-10-30 _Entry_origination author _NMR_STAR_version 2.1.1 _Experimental_method NMR _Details . loop_ _Author_ordinal _Author_family_name _Author_given_name _Author_middle_initials _Author_family_title 1 Lopez-Alonso Jorge P. . 2 Bruix Marta . . 3 Font Josep . . 4 Ribo Marc . . 5 Vilanova Maria . . 6 Morbio Manuela . . 7 Jimenez Maria A. . 8 Rico Manuel . . 9 Santoro Jorge . . 10 Gonzalez Carlos . . 11 Laurents Douglas V. . stop_ loop_ _Saveframe_category_type _Saveframe_category_type_count assigned_chemical_shifts 1 stop_ loop_ _Data_type _Data_type_count "1H chemical shifts" 228 "13C chemical shifts" 353 "15N chemical shifts" 115 stop_ loop_ _Revision_date _Revision_keyword _Revision_author _Revision_detail 2010-10-18 original author . stop_ loop_ _Related_BMRB_accession_number _Relationship 16011 'ribonuclease A in 8 M urea' 2928 'ribonuclease A' 4031 'bovine pancreatic ribonuclease A' 4032 'bovine pancreatic [C65S,C72S] ribonuclease A' 443 'ribonuclease A' stop_ _Original_release_date 2010-10-18 save_ ############################# # Citation for this entry # ############################# save_citation_1 _Saveframe_category entry_citation _Citation_full . _Citation_title 'NMR spectroscopy reveals that RNase A is chiefly denatured in 40% acetic acid: implications for oligomer formation by 3D domain swapping.' _Citation_status published _Citation_type journal _CAS_abstract_code . _MEDLINE_UI_code . _PubMed_ID 20085318 loop_ _Author_ordinal _Author_family_name _Author_given_name _Author_middle_initials _Author_family_title 1 Lopez-Alonso 'Jorge Pedro' . . 2 Bruix Marta . . 3 Font Josep . . 4 Ribo Marc . . 5 Vilanova Maria . . 6 Jimenez 'Maria Angeles' . . 7 Santoro Jorge . . 8 Gonzalez Carlos . . 9 Laurents Douglas V. . stop_ _Journal_abbreviation 'J. Am. Chem. Soc.' _Journal_name_full 'Journal of the American Chemical Society' _Journal_volume 132 _Journal_issue 5 _Journal_CSD . _Book_chapter_title . _Book_volume . _Book_series . _Book_ISBN . _Conference_state_province . _Conference_abstract_number . _Page_first 1621 _Page_last 1630 _Year 2010 _Details . save_ ################################## # Molecular system description # ################################## save_assembly _Saveframe_category molecular_system _Mol_system_name 'bovine pancreas ribonuclease A' _Enzyme_commission_number . loop_ _Mol_system_component_name _Mol_label 'ribonuclease A' $ribonuclease_A stop_ _System_molecular_weight . _System_physical_state unfolded _System_oligomer_state ? _System_paramagnetic no _System_thiol_state . _Database_query_date . _Details . save_ ######################## # Monomeric polymers # ######################## save_ribonuclease_A _Saveframe_category monomeric_polymer _Mol_type polymer _Mol_polymer_class protein _Name_common ribonuclease_A _Molecular_mass . _Mol_thiol_state 'all disulfide bound' _Details . ############################## # Polymer residue sequence # ############################## _Residue_count 124 _Mol_residue_sequence ; KETAAAKFERQHMDSSTSAA SSSNYCNQMMKSRNLTKDRC KPVNTFVHESLADVQAVCSQ KNVACKNGQTNCYQSYSTMS ITDCRETGSSKYPNCAYKTT QANKHIIVACEGNPYVPVHF DASV ; loop_ _Residue_seq_code _Residue_label 1 LYS 2 GLU 3 THR 4 ALA 5 ALA 6 ALA 7 LYS 8 PHE 9 GLU 10 ARG 11 GLN 12 HIS 13 MET 14 ASP 15 SER 16 SER 17 THR 18 SER 19 ALA 20 ALA 21 SER 22 SER 23 SER 24 ASN 25 TYR 26 CYS 27 ASN 28 GLN 29 MET 30 MET 31 LYS 32 SER 33 ARG 34 ASN 35 LEU 36 THR 37 LYS 38 ASP 39 ARG 40 CYS 41 LYS 42 PRO 43 VAL 44 ASN 45 THR 46 PHE 47 VAL 48 HIS 49 GLU 50 SER 51 LEU 52 ALA 53 ASP 54 VAL 55 GLN 56 ALA 57 VAL 58 CYS 59 SER 60 GLN 61 LYS 62 ASN 63 VAL 64 ALA 65 CYS 66 LYS 67 ASN 68 GLY 69 GLN 70 THR 71 ASN 72 CYS 73 TYR 74 GLN 75 SER 76 TYR 77 SER 78 THR 79 MET 80 SER 81 ILE 82 THR 83 ASP 84 CYS 85 ARG 86 GLU 87 THR 88 GLY 89 SER 90 SER 91 LYS 92 TYR 93 PRO 94 ASN 95 CYS 96 ALA 97 TYR 98 LYS 99 THR 100 THR 101 GLN 102 ALA 103 ASN 104 LYS 105 HIS 106 ILE 107 ILE 108 VAL 109 ALA 110 CYS 111 GLU 112 GLY 113 ASN 114 PRO 115 TYR 116 VAL 117 PRO 118 VAL 119 HIS 120 PHE 121 ASP 122 ALA 123 SER 124 VAL stop_ _Sequence_homology_query_date . _Sequence_homology_query_revised_last_date 2015-08-12 loop_ _Database_name _Database_accession_code _Database_entry_mol_name _Sequence_query_to_submitted_percentage _Sequence_subject_length _Sequence_identity _Sequence_positive _Sequence_homology_expectation_value BMRB 1072 "ribonuclease A" 100.00 124 100.00 100.00 1.55e-85 BMRB 16011 ribonuclease_A 100.00 124 100.00 100.00 1.55e-85 BMRB 16503 RNase_A 100.00 124 100.00 100.00 1.55e-85 BMRB 16742 "Ribonuclease A" 100.00 126 100.00 100.00 9.71e-86 BMRB 17099 ribonuclease 100.00 124 100.00 100.00 1.55e-85 BMRB 17172 RNase_A_C-dimer 100.00 124 100.00 100.00 1.55e-85 BMRB 19065 RnaseA 100.00 124 100.00 100.00 1.55e-85 BMRB 2928 "ribonuclease A" 100.00 124 100.00 100.00 1.55e-85 BMRB 385 "ribonuclease A" 100.00 124 100.00 100.00 1.55e-85 BMRB 4031 "bovine pancreatic ribonuclease A" 100.00 124 100.00 100.00 1.55e-85 BMRB 4032 "bovine pancreatic [C65S,C72S] ribonuclease A" 100.00 124 98.39 98.39 1.78e-83 BMRB 443 "ribonuclease A" 100.00 124 100.00 100.00 1.55e-85 PDB 1A2W "Crystal Structure Of A 3d Domain-Swapped Dimer Of Bovine Pancreatic Ribonuclease A" 100.00 124 100.00 100.00 1.55e-85 PDB 1A5P "C[40,95]a Variant Of Bovine Pancreatic Ribonuclease A" 100.00 124 98.39 98.39 1.03e-83 PDB 1A5Q "P93a Variant Of Bovine Pancreatic Ribonuclease A" 100.00 124 99.19 99.19 1.72e-84 PDB 1AFK "Crystal Structure Of Ribonuclease A In Complex With 5'- Diphosphoadenosine-3'-Phosphate" 100.00 124 100.00 100.00 1.55e-85 PDB 1AFL "Ribonuclease A In Complex With 5'-Diphosphoadenosine 2'- Phosphate At 1.7 Angstrom Resolution" 100.00 124 100.00 100.00 1.55e-85 PDB 1AFU "Structure Of Ribonuclease A At 2.0 Angstroms From Monoclinic Crystals" 100.00 124 100.00 100.00 1.55e-85 PDB 1AQP "Ribonuclease A Copper Complex" 100.00 124 100.00 100.00 1.55e-85 PDB 1BEL "Hydrolase Phosphoric Diester, Rna" 100.00 124 100.00 100.00 1.55e-85 PDB 1BZQ "Complex Of A Dromedary Single-Domain Vhh Antibody Fragment With Rnase A" 100.00 124 100.00 100.00 1.55e-85 PDB 1C0B "Bovine Pancreatic Ribonuclease A Desiccated For 2.5 Days" 100.00 128 100.00 100.00 1.50e-85 PDB 1C0C "Bovine Pancreatic Ribonuclease A Desiccated For 4.0 Days" 100.00 128 100.00 100.00 1.50e-85 PDB 1C8W "Thr45gly Variant Of Ribonuclease A" 100.00 124 99.19 99.19 1.61e-84 PDB 1C9V "H12a Variant Of Ribonuclease A" 100.00 124 99.19 99.19 3.53e-84 PDB 1C9X "H119a Variant Of Ribonuclease A" 100.00 124 99.19 99.19 3.53e-84 PDB 1CJQ "X-Ray Crystallographic Studies Of The Denaturation Of The Denaturation Of Ribonuclease S." 81.45 101 100.00 100.00 1.72e-68 PDB 1CJR "X-Ray Crystallographic Studies Of Denaturation In Ribonuclease S" 80.65 101 100.00 100.00 7.51e-68 PDB 1D5D "The Role Of Phenylalanine 8 In The Stabilization Of The S Protein-S Peptide Interaction: Packing And Cavities" 81.45 101 100.00 100.00 1.72e-68 PDB 1D5E "The Role Of Phenylalanine 8 In The Stabilization Of The S Protein-S Peptide Interaction: Packing And Cavities" 81.45 101 100.00 100.00 1.72e-68 PDB 1D5H "Rnase S(F8a). Mutant Ribonuclease S" 81.45 101 100.00 100.00 1.72e-68 PDB 1DFJ "Ribonuclease Inhibitor Complexed With Ribonuclease A" 100.00 124 100.00 100.00 1.55e-85 PDB 1DY5 "Deamidated Derivative Of Bovine Pancreatic Ribonuclease" 100.00 124 99.19 99.19 1.47e-84 PDB 1EIC "Crystal Structure Of F120a Mutant Of Bovine Pancreatic Ribonuclease A" 100.00 124 99.19 99.19 3.34e-84 PDB 1EID "Crystal Structure Of F120g Mutant Of Bovine Pancreatic Ribonuclease A" 100.00 124 99.19 99.19 3.81e-84 PDB 1EIE "Crystal Structure Of F120w Mutant Of Bovine Pancreatic Ribonuclease A" 100.00 124 99.19 100.00 5.00e-85 PDB 1EOS "Crystal Structure Of Ribonuclease A Complexed With Uridylyl(2',5')guanosine (Productive Binding)" 100.00 124 100.00 100.00 1.55e-85 PDB 1EOW "Crystal Structure Of Ribonuclease A Complexed With Uridylyl(2',5')guanosine (Non-Productive Binding)" 100.00 124 100.00 100.00 1.55e-85 PDB 1F0V "Crystal Structure Of An Rnase A Dimer Displaying A New Type Of 3d Domain Swapping" 100.00 124 100.00 100.00 1.55e-85 PDB 1FEV "Crystal Structure Of The Ala4aib Mutation In Rnase S" 81.45 101 100.00 100.00 1.72e-68 PDB 1FS3 "Crystal Structure Of Wild-Type Bovine Pancreatic Ribonuclease A" 100.00 124 100.00 100.00 1.55e-85 PDB 1IZP "F46l Mutant Of Bovine Pancreatic Ribonuclease A" 100.00 124 99.19 99.19 7.40e-85 PDB 1IZQ "F46v Mutant Of Bovine Pancreatic Ribonuclease A" 100.00 124 99.19 99.19 1.44e-84 PDB 1IZR "F46a Mutant Of Bovine Pancreatic Ribonuclease A" 100.00 124 99.19 99.19 3.34e-84 PDB 1J7Z "Osmolyte Stabilization Of Ribonuclease" 83.87 104 100.00 100.00 3.13e-70 PDB 1J80 "Osmolyte Stabilization Of Rnase" 83.87 104 100.00 100.00 3.13e-70 PDB 1J81 "Osmolyte Stabilization Of Rnase" 83.87 104 100.00 100.00 3.13e-70 PDB 1J82 "Osmolyte Stabilization Of Rnase" 83.87 104 100.00 100.00 3.13e-70 PDB 1JN4 "The Crystal Structure Of Ribonuclease A In Complex With 2'- Deoxyuridine 3'-Pyrophosphate (P'-5') Adenosine" 100.00 124 100.00 100.00 1.55e-85 PDB 1JS0 "Crystal Structure Of 3d Domain-Swapped Rnase A Minor Trimer" 100.00 124 100.00 100.00 1.55e-85 PDB 1JVT "Crystal Structure Of Ribonuclease A (Ligand-Free Form)" 100.00 124 100.00 100.00 1.55e-85 PDB 1JVU "Crystal Structure Of Ribonuclease A (Complexed Form)" 100.00 124 100.00 100.00 1.55e-85 PDB 1JVV "Crystal Structure Of Ribonuclease A (Retro-Soaked Form)" 100.00 124 100.00 100.00 1.55e-85 PDB 1KF2 "Atomic Resolution Structure Of Rnase A At Ph 5.2" 100.00 124 100.00 100.00 1.55e-85 PDB 1KF3 "Atomic Resolution Structure Of Rnase A At Ph 5.9" 100.00 124 100.00 100.00 1.55e-85 PDB 1KF4 "Atomic Resolution Structure Of Rnase A At Ph 6.3" 100.00 124 100.00 100.00 1.55e-85 PDB 1KF5 "Atomic Resolution Structure Of Rnase A At Ph 7.1" 100.00 124 100.00 100.00 1.55e-85 PDB 1KF7 "Atomic Resolution Structure Of Rnase A At Ph 8.0" 100.00 124 100.00 100.00 1.55e-85 PDB 1KF8 "Atomic Resolution Structure Of Rnase A At Ph 8.8" 100.00 124 100.00 100.00 1.55e-85 PDB 1KH8 "Structure Of A Cis-Proline (P114) To Glycine Variant Of Ribonuclease A" 100.00 125 99.19 99.19 2.41e-84 PDB 1LSQ "Ribonuclease A With Asn 67 Replaced By A Beta-Aspartyl Residue" 100.00 124 99.19 99.19 1.47e-84 PDB 1O0F "Rnase A In Complex With 3',5'-Adp" 100.00 124 100.00 100.00 1.55e-85 PDB 1O0H "Ribonuclease A In Complex With 5'-Adp" 100.00 124 100.00 100.00 1.55e-85 PDB 1O0M "Ribonuclease A In Complex With Uridine-2'-Phosphate" 100.00 124 100.00 100.00 1.55e-85 PDB 1O0N "Ribonuclease A In Complex With Uridine-3'-phosphate" 100.00 124 100.00 100.00 1.55e-85 PDB 1O0O "Ribonuclease A In Complex With Adenosine-2',5'-Diphosphate" 100.00 124 100.00 100.00 1.55e-85 PDB 1QHC "Crystal Structure Of Ribonuclease A In Complex With 5'- Phospho-2'-Deoxyuridine-3'-Pyrophosphate Adenosine-3'- Phosphate" 100.00 124 100.00 100.00 1.55e-85 PDB 1RAR "Crystal Structure Of A Fluorescent Derivative Of Rnase A" 99.19 123 100.00 100.00 8.92e-85 PDB 1RAS "Crystal Structure Of A Fluorescent Derivative Of Rnase A" 99.19 123 100.00 100.00 8.92e-85 PDB 1RAT "Effects Of Temperature On Protein Structure And Dynamics: X- Ray Crystallographic Studies Of The Protein Ribonuclease-A At Nine" 100.00 124 100.00 100.00 1.55e-85 PDB 1RBB "The Crystal Structure Of Ribonuclease B At 2.5-Angstroms Resolution" 100.00 124 100.00 100.00 1.55e-85 PDB 1RBC "Crystallographic Structures Of Ribonuclease S Variants With Nonpolar Substitution At Position 13: Packing And Cavities" 83.87 104 100.00 100.00 3.13e-70 PDB 1RBD "Crystallographic Structures Of Ribonuclease S Variants With Nonpolar Substitution At Position 13: Packing And Cavities" 83.87 104 100.00 100.00 3.13e-70 PDB 1RBE "Crystallographic Structures Of Ribonuclease S Variants With Nonpolar Substitution At Position 13: Packing And Cavities" 83.87 104 100.00 100.00 3.13e-70 PDB 1RBF "Crystallographic Structures Of Ribonuclease S Variants With Nonpolar Substitution At Position 13: Packing And Cavities" 83.87 104 100.00 100.00 3.13e-70 PDB 1RBG "Crystallographic Structures Of Ribonuclease S Variants With Nonpolar Substitution At Position 13: Packing And Cavities" 83.87 104 100.00 100.00 3.13e-70 PDB 1RBH "Crystallographic Structures Of Ribonuclease S Variants With Nonpolar Substitution At Position 13: Packing And Cavities" 83.87 104 100.00 100.00 3.13e-70 PDB 1RBI "Crystallographic Structures Of Ribonuclease S Variants With Nonpolar Substitution At Position 13: Packing And Cavities" 83.87 104 100.00 100.00 3.13e-70 PDB 1RBJ "Ribonuclease B Complex With D(Tetra-(Deoxy-Adenylate))" 100.00 124 100.00 100.00 1.55e-85 PDB 1RBN "The Structure Of Ribonuclease A Derivative Ii At 2.1 Angstroms Resolution" 100.00 124 100.00 100.00 1.55e-85 PDB 1RBW "Ribonuclease A (E.C.3.1.27.5) With Guanidinium" 100.00 124 100.00 100.00 1.55e-85 PDB 1RBX "Ribonuclease A (E.C.3.1.27.5) Control" 100.00 124 100.00 100.00 1.55e-85 PDB 1RCA "Structure Of The Crystalline Complex Of Deoxycytidylyl-3', 5'-Guanosine (3',5'-Dcpdg) Co-Crystalised With Ribonuclease At 1.9 A" 100.00 124 100.00 100.00 1.55e-85 PDB 1RCN "Crystal Structure Of The Ribonuclease A D(Aptpapapg) Complex : Direct Evidence For Extended Substrate Recognition" 100.00 124 100.00 100.00 1.55e-85 PDB 1RHA "Water Dependent Domain Motion And Flexibility In Ribonuclease A And The Invariant Features In Its Hydration Shell. An X-Ray Stu" 100.00 124 100.00 100.00 1.55e-85 PDB 1RHB "Water Dependent Domain Motion And Flexibility In Ribonuclease A And The Invariant Features In Its Hydration Shell. An X-Ray Stu" 100.00 124 100.00 100.00 1.55e-85 PDB 1RNC "Newly Observed Binding Mode In Pancreatic Ribonuclease" 100.00 124 100.00 100.00 1.55e-85 PDB 1RND "Newly Observed Binding Mode In Pancreatic Ribonuclease" 100.00 124 100.00 100.00 1.55e-85 PDB 1RNM "Ribonuclease A Complex With Cytidylic Acid (5'cmp) Crystallized From 80% Ammonium Sulphate" 100.00 124 100.00 100.00 1.55e-85 PDB 1RNN "Ribonuclease A Complex With Cytidylic Acid (5'cmp) Crystallized From 8m Sodium Formate" 100.00 124 100.00 100.00 1.55e-85 PDB 1RNO "Ribonuclease A Crystallized From 80% Ammonium Sulphate" 100.00 124 100.00 100.00 1.55e-85 PDB 1RNQ "Ribonuclease A Crystallized From 8m Sodium Formate" 100.00 124 100.00 100.00 1.55e-85 PDB 1RNU "Refinement Of The Crystal Structure Of Ribonuclease S. Comparison With And Between The Various Ribonuclease A Structures" 100.00 124 100.00 100.00 1.55e-85 PDB 1RNV "Refinement Of The Crystal Structure Of Ribonuclease S. Comparison With And Between The Various Ribonuclease A Structures" 100.00 124 100.00 100.00 1.55e-85 PDB 1RNW "Recombinant Ribonuclease A Crystallized From 80% Ammonium Sulphate" 100.00 124 100.00 100.00 1.55e-85 PDB 1RNX "Ribonuclease A Crystallized From 3m Sodium Chloride, 30% Ammonium Sulfate" 100.00 124 100.00 100.00 1.55e-85 PDB 1RNY "Ribonuclease A Crystallized From 3m Cesium Chloride, 30% Ammonium Sulfate" 100.00 124 100.00 100.00 1.55e-85 PDB 1RNZ "Ribonuclease A Crystallized From 2.5m Sodium Chloride, 3.3m Sodium Formate" 100.00 124 100.00 100.00 1.55e-85 PDB 1ROB "Structure Of The Crystalline Complex Of Cytidylic Acid (2'- Cmp) With Ribonuclease At 1.6 Angstroms Resolution" 100.00 124 100.00 100.00 1.55e-85 PDB 1RPF "The Structures Of Rnase Complexed With 3'-Cmp And D(Cpa): Active Site Conformation And Conserved Water Molecules" 100.00 124 100.00 100.00 1.55e-85 PDB 1RPG "Structures Of Rnase A Complexed With 3'-Cmp And D(Cpa): Active Site Conformation And Conserved Water Molecules" 100.00 124 100.00 100.00 1.55e-85 PDB 1RPH "Structures Of Rnase A Complexed With 3'-Cmp And D(Cpa): Active Site Conformation And Conserved Water Molecules" 100.00 124 100.00 100.00 1.55e-85 PDB 1RSM "The 2-Angstroms Resolution Structure Of A Thermostable Ribonuclease A Chemically Cross-Linked Between Lysine Residues 7 And 41" 100.00 124 100.00 100.00 1.55e-85 PDB 1RTA "Crystal Structure Disposition Of Thymidylic Acid Tetramer In Complex With Ribonuclease A" 100.00 124 100.00 100.00 1.55e-85 PDB 1RTB "Crystal Structure Disposition Of Thymidylic Acid Tetramer In Complex With Ribonuclease A" 100.00 124 100.00 100.00 1.55e-85 PDB 1RUV "Ribonuclease A-Uridine Vanadate Complex: High Resolution Resolution X-Ray Structure (1.3 A)" 100.00 124 100.00 100.00 1.55e-85 PDB 1SRN "The Refined Crystal Structure Of A Fully Active Semisynthetic Ribonuclease At 1.8 Angstroms Resolution" 95.16 118 100.00 100.00 1.64e-80 PDB 1SSA "A Structural Investigation Of Catalytically Modified F12ol And F12oy Semisynthetic Ribonucleases" 95.16 118 100.00 100.00 1.64e-80 PDB 1SSB "A Structural Investigation Of Catalytically Modified F12ol And F12oy Semisynthetic Ribonucleases" 95.16 118 100.00 100.00 1.64e-80 PDB 1SSC "The 1.6 Angstroms Structure Of A Semisynthetic Ribonuclease Crystallized From Aqueous Ethanol. Comparison With Crystals From Sa" 90.32 112 100.00 100.00 2.88e-75 PDB 1U1B "Structure Of Bovine Pancreatic Ribonuclease A In Complex With 3'-phosphothymidine (3'-5')-pyrophosphate Adenosine 3'-phosphate" 100.00 124 100.00 100.00 1.55e-85 PDB 1W4O "Binding Of Nonnatural 3'-Nucleotides To Ribonuclease A" 100.00 124 100.00 100.00 1.55e-85 PDB 1W4P "Binding Of Nonnatural 3'-Nucleotides To Ribonuclease A" 100.00 124 100.00 100.00 1.55e-85 PDB 1W4Q "Binding Of Nonnatural 3'-Nucleotides To Ribonuclease A" 100.00 124 100.00 100.00 1.55e-85 PDB 1WBU "Fragment Based Lead Discovery Using Crystallography" 100.00 124 100.00 100.00 1.55e-85 PDB 1XPS "Bovine Ribonuclease A (Phosphate-Free) (93 % Humidity)" 100.00 124 100.00 100.00 1.55e-85 PDB 1XPT "Bovine Ribonuclease A (Phosphate-Free)" 100.00 124 100.00 100.00 1.55e-85 PDB 1YMN "The Study Of Reductive Unfolding Pathways Of Rnase A (Y92l Mutant)" 100.00 124 99.19 99.19 1.22e-84 PDB 1YMR "The Study Of Reductive Unfolding Pathways Of Rnase A (Y92a Mutant)" 100.00 124 99.19 99.19 2.49e-84 PDB 1YMW "The Study Of Reductive Unfolding Pathways Of Rnase A (Y92g Mutant)" 100.00 124 99.19 99.19 3.57e-84 PDB 1Z3L "X-Ray Crystal Structure Of A Mutant Ribonuclease S (F8anb)" 83.87 104 100.00 100.00 3.13e-70 PDB 1Z3M "Crystal Structure Of Mutant Ribonuclease S (F8nva)" 83.87 104 100.00 100.00 3.13e-70 PDB 1Z3P "X-Ray Crystal Structure Of A Mutant Ribonuclease S (M13nva)" 83.87 104 100.00 100.00 3.13e-70 PDB 1Z6D "Ribonuclease A- Imp Complex" 100.00 124 100.00 100.00 1.55e-85 PDB 1Z6S "Ribonuclease A- Amp Complex" 100.00 124 100.00 100.00 1.55e-85 PDB 2AAS "High-Resolution Three-Dimensional Structure Of Ribonuclease A In Solution By Nuclear Magnetic Resonance Spectroscopy" 100.00 124 100.00 100.00 1.55e-85 PDB 2BLP "Rnase Before Unattenuated X-Ray Burn" 100.00 124 100.00 100.00 1.55e-85 PDB 2BLZ 'Rnase After A High Dose X-Ray "burn"' 100.00 124 100.00 100.00 1.55e-85 PDB 2E33 "Structural Basis For Selection Of Glycosylated Substrate By Scffbs1 Ubiquitin Ligase" 100.00 124 100.00 100.00 1.55e-85 PDB 2E3W "X-Ray Structure Of Native Rnase A" 100.00 124 100.00 100.00 1.55e-85 PDB 2G4W "Anomalous Substructure Of Ribonuclease A (c2)" 100.00 124 100.00 100.00 1.55e-85 PDB 2G4X "Anomalous Substructure Od Ribonuclease A (P3221)" 100.00 124 100.00 100.00 1.55e-85 PDB 2G8Q "The Crystal Structure Of Rnase A From Monoclinic Crystals At 100 K" 100.00 124 100.00 100.00 1.55e-85 PDB 2G8R "The Crystal Structure Of The Rnase A- 3-N-Piperidine-4- Carboxyl-3-Deoxy-Ara-Uridine Complex" 100.00 124 100.00 100.00 1.55e-85 PDB 2NUI "X-Ray Structure Of Synthetic [d83a]rnase A" 100.00 124 99.19 99.19 2.69e-84 PDB 2OP2 "Crystal Structure Of Rnase Double-Mutant V43c R85c With Extra Disulphide Bond" 100.00 124 98.39 98.39 8.84e-83 PDB 2OQF "Structure Of A Synthetic, Non-Natural Analogue Of Rnase A: [n71k(Ade), D83a]rnase A" 100.00 124 98.39 98.39 2.23e-83 PDB 2P42 "Complex Of A Camelid Single-Domain Vhh Antibody Fragment With Rnase A At 1.8a Resolution: Se3-Mono-2 Crystal Form With Three Se" 100.00 124 100.00 100.00 1.55e-85 PDB 2P43 "Complex Of A Camelid Single-Domain Vhh Antibody Fragment With Rnase A At 1.65a Resolution: Se3-Mono-1 Crystal Form With Three S" 100.00 124 100.00 100.00 1.55e-85 PDB 2P44 "Complex Of A Camelid Single-Domain Vhh Antibody Fragment With Rnase A At 1.8a Resolution: Se5a-Mono-1 Crystal Form With Five Se" 100.00 124 100.00 100.00 1.55e-85 PDB 2P45 "Complex Of A Camelid Single-domain Vhh Antibody Fragment With Rnase A At 1.1a Resolution: Se5b-ortho-1 Crystal Form With Five S" 100.00 124 100.00 100.00 1.55e-85 PDB 2P46 "Complex Of A Camelid Single-Domain Vhh Antibody Fragment With Rnase A At 2.5a Resolution: Se5b-Ortho-2 Crystal Form With Five S" 100.00 124 100.00 100.00 1.55e-85 PDB 2P47 "Complex Of A Camelid Single-Domain Vhh Antibody Fragment With Rnase A At 2.5a Resolution: Se5b-Tri Crystal Form With Five Se-Me" 100.00 124 100.00 100.00 1.55e-85 PDB 2P48 "Complex Of A Camelid Single-Domain Vhh Antibody Fragment With Rnase A At 2.3a Resolution: Se5b-Tetra Crystal Form With Five Se-" 100.00 124 100.00 100.00 1.55e-85 PDB 2P49 "Complex Of A Camelid Single-Domain Vhh Antibody Fragment With Rnase A At 1.4a Resolution: Native Mono_1 Crystal Form" 100.00 124 100.00 100.00 1.55e-85 PDB 2P4A "X-Ray Structure Of A Camelid Affinity Matured Single-Domain Vhh Antibody Fragment In Complex With Rnase A" 100.00 124 100.00 100.00 1.55e-85 PDB 2QCA "A New Crystal Form Of Bovine Pancreatic Rnase A In Complex With 2'- Deoxyguanosine-5'-Monophosphate" 100.00 124 100.00 100.00 1.55e-85 PDB 2RAT "Effects Of Temperature On Protein Structure And Dynamics: X- Ray Crystallographic Studies Of The Protein Ribonuclease-A At Nine" 100.00 124 100.00 100.00 1.55e-85 PDB 2RLN "Thermodynamic And Structural Consequences Of Changing A Sulphur Atom To A Methylene Group In The M13nle Mutation In Ribonucleas" 87.90 109 100.00 100.00 2.37e-73 PDB 2RNS "Refinement Of The Crystal Structure Of Ribonuclease S. Comparison With And Between The Various Ribonuclease A Structures" 100.00 124 100.00 100.00 1.55e-85 PDB 2W5G "Rnase A-5'-Atp Complex" 100.00 124 100.00 100.00 1.55e-85 PDB 2W5I "Rnase A-Ap3a Complex" 100.00 124 100.00 100.00 1.55e-85 PDB 2W5K "Rnase A-Nadph Complex" 100.00 124 100.00 100.00 1.55e-85 PDB 2W5L "Rnase A-Nadp Complex" 100.00 124 100.00 100.00 1.55e-85 PDB 2W5M "Rnase A-Pyrophosphate Ion Complex" 100.00 124 100.00 100.00 1.55e-85 PDB 2XOG "Functional And Structural Analyses Of N-Acylsulfonamide- Linked Dinucleoside Inhibitors Of Ribonuclease A" 100.00 124 100.00 100.00 1.55e-85 PDB 2XOI "Functional And Structural Analyses Of N-Acylsulfonamide- Linked Dinucleoside Inhibitors Of Ribonuclease A" 100.00 124 100.00 100.00 1.55e-85 PDB 3A1R "Neutron Crystal Structure Analysis Of Bovine Pancreatic Ribonuclease A" 100.00 124 100.00 100.00 1.55e-85 PDB 3D6O "The Rnase A- 5'-Deoxy-5'-N-(Ethyl Isonipecotatyl)uridine Complex" 100.00 124 100.00 100.00 1.55e-85 PDB 3D6P "Rnase A- 5'-Deoxy-5'-N-Morpholinouridine Complex" 100.00 124 100.00 100.00 1.55e-85 PDB 3D6Q "The Rnase A- 5'-Deoxy-5'-N-Piperidinouridine Complex" 100.00 124 100.00 100.00 1.55e-85 PDB 3D7B "The Ribonuclease A- 5'-Deoxy-5'-N-Pyrrolidinouridine Complex" 100.00 124 100.00 100.00 1.55e-85 PDB 3D8Y "Rnase A- 5'-deoxy-5'-n-piperidinothymidine Complex" 100.00 124 100.00 100.00 1.55e-85 PDB 3D8Z "Rnase A- 5'-deoxy-5'-n-pyrrolidinothymidine Complex" 100.00 124 100.00 100.00 1.55e-85 PDB 3DH5 "Crystal Structure Of Bovine Pancreatic Ribonuclease A (Wild- Type)" 100.00 124 100.00 100.00 1.55e-85 PDB 3DH6 "Crystal Structure Of Bovine Pancreatic Ribonuclease A Variant (V47a)" 100.00 124 99.19 99.19 8.08e-85 PDB 3DI7 "Crystal Structure Of Bovine Pancreatic Ribonuclease A Variant (V54a)" 100.00 124 99.19 99.19 8.08e-85 PDB 3DI8 "Crystal Structure Of Bovine Pancreatic Ribonuclease A Variant (V57a)" 100.00 124 99.19 99.19 8.08e-85 PDB 3DI9 "Crystal Structure Of Bovine Pancreatic Ribonuclease A Variant (I81a)" 100.00 124 99.19 99.19 1.43e-84 PDB 3DIB "Crystal Structure Of Bovine Pancreatic Ribonuclease A Variant (I106a)" 100.00 124 99.19 99.19 1.43e-84 PDB 3DIC "Crystal Structure Of Bovine Pancreatic Ribonuclease A Variant (V108a)" 100.00 124 99.19 99.19 8.08e-85 PDB 3DXG "Ribonuclease A- Uridine 5' Phosphate Complex" 100.00 124 100.00 100.00 1.55e-85 PDB 3DXH "Ribonuclease A Uridine 5' Diphosphate Complex" 100.00 124 100.00 100.00 1.55e-85 PDB 3EUX "Crystal Structure Of Crosslinked Ribonuclease A" 100.00 124 100.00 100.00 1.55e-85 PDB 3EUY "Crystal Structure Of Ribonuclease A In 50% Dioxane" 100.00 124 100.00 100.00 1.55e-85 PDB 3EUZ "Crystal Structure Of Ribonuclease A In 50% Dimethylformamide" 100.00 124 100.00 100.00 1.55e-85 PDB 3EV0 "Crystal Structure Of Ribonuclease A In 70% Dimethyl Sulfoxide" 100.00 124 100.00 100.00 1.55e-85 PDB 3EV1 "Crystal Structure Of Ribonuclease A In 70% Hexanediol" 100.00 124 100.00 100.00 1.55e-85 PDB 3EV2 "Crystal Structure Of Ribonuclease A In 70% Isopropanol" 100.00 124 100.00 100.00 1.55e-85 PDB 3EV3 "Crystal Structure Of Ribonuclease A In 70% T-Butanol" 100.00 124 100.00 100.00 1.55e-85 PDB 3EV4 "Crystal Structure Of Ribonuclease A In 50% Trifluoroethanol" 100.00 124 100.00 100.00 1.55e-85 PDB 3EV5 "Crystal Structure Of Ribonuclease A In 1m Trimethylamine N-Oxide" 100.00 124 100.00 100.00 1.55e-85 PDB 3EV6 "Crystal Structure Of Ribonuclease A In 50% R,S,R-Bisfuranol" 100.00 124 100.00 100.00 1.55e-85 PDB 3FL0 "X-Ray Structure Of The Non Covalent Swapped Form Of The Q28lK31CS32C MUTANT OF BOVINE PANCREATIC RIBONUCLEASE IN Complex With 2" 100.00 124 97.58 97.58 5.18e-83 PDB 3I67 "Ribonuclease A By Lb Nanotemplate Method After High X-Ray Dose On Esrf Id14-2 Beamline" 100.00 124 100.00 100.00 1.55e-85 PDB 3I6F "Ribonuclease A By Classical Hanging Drop Method Before High X-Ray Dose On Esrf Id14-2 Beamline" 100.00 124 100.00 100.00 1.55e-85 PDB 3I6H "Ribonuclease A By Lb Nanotemplate Method Before High X-Ray Dose On Esrf Id14-2 Beamline" 100.00 124 100.00 100.00 1.55e-85 PDB 3I6J "Ribonuclease A By Classical Hanging Drop Method After High X-Ray Dose On Esrf Id14-2 Beamline" 100.00 124 100.00 100.00 1.55e-85 PDB 3I7W "High Pressure Structure Of Wild-Type Rnase A (0.67 Gpa)" 100.00 124 100.00 100.00 1.55e-85 PDB 3I7X "High Pressure Structure Of I106a Rnase A Variant (0.35 Gpa)" 100.00 124 99.19 99.19 1.43e-84 PDB 3I7Y "High Pressure Structure Of I106a Variant Of Rnase A (0.48 Gpa)" 100.00 124 99.19 99.19 1.43e-84 PDB 3JW1 "Crystal Structure Of Bovine Pancreatic Ribonuclease Complexed With Uridine-5'-monophosphate At 1.60 A Resolution" 100.00 124 100.00 100.00 1.55e-85 PDB 3LXO "The Crystal Structure Of Ribonuclease A In Complex With Thymidine-3'- Monophosphate" 100.00 124 100.00 100.00 1.55e-85 PDB 3MWQ "Crystal Structure Of Ribonuclease A Tandem Enzymes And Their Interaction With The Cytosolic Ribonuclease Inhibitor" 100.00 256 100.00 100.00 1.07e-83 PDB 3MWR "Crystal Structure Of Ribonuclease A Tandem Enzymes And Their Interaction With The Cytosolic Ribonuclease Inhibitor" 100.00 254 100.00 100.00 9.17e-84 PDB 3MX8 "Crystal Structure Of Ribonuclease A Tandem Enzymes And Their Interaction With The Cytosolic Ribonuclease Inhibitor" 100.00 252 100.00 100.00 1.34e-83 PDB 3MZQ "Rnase Crystals Grown By The Hanging Drop Method" 100.00 128 100.00 100.00 1.50e-85 PDB 3MZR "Rnase Crystals Grown In Loops/micromounts" 100.00 128 100.00 100.00 1.50e-85 PDB 3OQY "Semi-Synthetic Ribonuclease S: Para-Cyano-Phenylalanine At Position 8" 83.87 104 100.00 100.00 3.13e-70 PDB 3OQZ "Semi-Synthetic Ribonuclease S: Meta-Cyano-Phenylalanine At Position 8" 83.87 104 100.00 100.00 3.13e-70 PDB 3OR0 "Semi-Synthetic Ribonuclease S: Cyanylated Homocysteine At Position 13" 83.87 104 100.00 100.00 3.13e-70 PDB 3QL1 "Crystal Structure Of Ribonuclease A Variant A4c/d83e/v118c" 100.00 124 97.58 98.39 7.26e-83 PDB 3QL2 "Crystal Structure Of Ribonuclease A Variant A4c/d83e/v118c" 100.00 124 97.58 98.39 7.26e-83 PDB 3QSK "5 Histidine Variant Of The Anti-Rnase A Vhh In Complex With Rnase A" 100.00 124 100.00 100.00 1.55e-85 PDB 3RAT "Effects Of Temperature On Protein Structure And Dynamics: X- Ray Crystallographic Studies Of The Protein Ribonuclease-A At Nine" 100.00 124 100.00 100.00 1.55e-85 PDB 3RH1 "X-ray Structure Of A Cis-proline (p114) To Alanine Variant Of Ribonuclease A" 100.00 124 99.19 99.19 1.72e-84 PDB 3RID "X-ray Structure Of The C-terminal Swapped Dimer Of P114a Variant Of Ribonuclease A" 100.00 124 99.19 99.19 1.72e-84 PDB 3RN3 "Segmented Anisotropic Refinement Of Bovine Ribonuclease A By The Application Of The Rigid-Body Tls Model" 100.00 124 100.00 100.00 1.55e-85 PDB 3RSD "Structure Of The D121n Variant Of Ribonuclease A" 100.00 124 99.19 100.00 9.31e-85 PDB 3RSK "Structure Of The K7aR10AK66A VARIANT OF RIBONUCLEASE A" 100.00 124 97.58 97.58 9.13e-83 PDB 3RSP "Structure Of The P93g Variant Of Ribonuclease A" 100.00 124 99.19 99.19 2.57e-84 PDB 3SRN "Structural Changes That Accompany The Reduced Catalytic Efficiency Of Two Semisynthetic Ribonuclease Analogs" 91.13 113 100.00 100.00 5.36e-76 PDB 4AO1 "High Resolution Crystal Structure Of Bovine Pancreatic Ribonuclease Crystallized Using Ionic Liquid" 100.00 124 100.00 100.00 1.55e-85 PDB 4G8V "Crystal Structure Of Ribonuclease A In Complex With 5a" 100.00 124 100.00 100.00 1.55e-85 PDB 4G8Y "Crystal Structure Of Ribonuclease A In Complex With 5b" 100.00 124 100.00 100.00 1.55e-85 PDB 4G90 "Crystal Structure Of Ribonuclease A In Complex With 5e" 100.00 124 100.00 100.00 1.55e-85 PDB 4J5Z "Crystal Structure Of Ribonuclease A In Aqueous Solution: One Of Twelve In Mscs Set" 100.00 124 100.00 100.00 1.55e-85 PDB 4J60 "Crystal Structure Of Ribonuclease A Soaked In 25% Cyclopentanol: One Of Twelve In Mscs Set" 100.00 124 100.00 100.00 1.55e-85 PDB 4J61 "Crystal Structure Of Ribonuclease A Soaked In 40% Cyclopentanone: One Of Twelve In Mscs Set" 100.00 124 100.00 100.00 1.55e-85 PDB 4J62 "Crystal Structure Of Ribonuclease A Soaked In 40% Cyclohexanol: One Of Twelve In Mscs Set" 100.00 124 100.00 100.00 1.55e-85 PDB 4J63 "Crystal Structure Of Ribonuclease A Soaked In 40% Cyclohexanone: One Of Twelve In Mscs Set" 100.00 124 100.00 100.00 1.55e-85 PDB 4J64 "Crystal Structure Of Ribonuclease A Soaked In 40% Dioxane: One Of Twelve In Mscs Set" 100.00 124 100.00 100.00 1.55e-85 PDB 4J65 "Crystal Structure Of Ribonuclease A Soaked In 40% Dimethylformamide: One Of Twelve In Mscs Set" 100.00 124 100.00 100.00 1.55e-85 PDB 4J66 "Crystal Structure Of Ribonuclease A Soaked In 25% Dimethyl Sulfoxide: One Of Twelve In Mscs Set" 100.00 124 100.00 100.00 1.55e-85 PDB 4J67 "Crystal Structure Of Ribonuclease A Soaked In 50% 1,6-hexanediol: One Of Twelve In Mscs Set" 100.00 124 100.00 100.00 1.55e-85 PDB 4J68 "Crystal Structure Of Ribonuclease A Soaked In 40% Isopropanol: One Of Twelve In Mscs Set" 100.00 124 100.00 100.00 1.55e-85 PDB 4J69 "Crystal Structure Of Ribonuclease A Soaked In 50% S,r,s-bisfuranol: One Of Twelve In Mscs Set" 100.00 124 100.00 100.00 1.55e-85 PDB 4J6A "Crystal Structure Of Ribonuclease A Soaked In 40% 2,2,2- Trifluoroethanol: One Of Twelve In Mscs Set" 100.00 124 100.00 100.00 1.55e-85 PDB 4K7L "Crystal Structure Of Rnase S Variant (k7c/q11c)" 83.87 104 100.00 100.00 3.13e-70 PDB 4L55 "X-ray Structure Of The Adduct Between Bovine Pancreatic Ribonuclease And Aziru" 100.00 124 100.00 100.00 1.55e-85 PDB 4MXF "X-ray Structure Of The Adduct Between Bovine Pancreatic Ribonuclease And Auoxo6, A Dinuclear Gold(iii) Complex With -dioxo Brid" 100.00 124 100.00 100.00 1.55e-85 PDB 4O36 "Semisynthetic Rnase S1-15-h7/11-q10" 83.87 104 100.00 100.00 3.13e-70 PDB 4O37 "Seminsynthetic Rnase S1-15-3pl-7/11" 83.87 104 100.00 100.00 3.13e-70 PDB 4OKF "Rnase S In Complex With An Artificial Peptide" 83.87 104 100.00 100.00 3.13e-70 PDB 4OOH "Structure Of Ribonuclease A At 40c" 100.00 124 100.00 100.00 1.55e-85 PDB 4OT4 "X-ray Structure Of The Adduct Formed Between Cisplatin And Ribonuclease A" 100.00 124 100.00 100.00 1.55e-85 PDB 4PEQ "Structure Of Bovine Ribonuclease Inhibitor Complexed With Bovine Ribonuclease I" 100.00 124 100.00 100.00 1.55e-85 PDB 4POU "Vhh-metal In Complex With Rnase A" 100.00 124 100.00 100.00 1.55e-85 PDB 4QH3 "X-ray Structure Of The Adduct Formed Between Bovine Pancreatic Ribonuclease And Trans-dimethylamine Methylamine Dichlorido Plat" 100.00 124 100.00 100.00 1.55e-85 PDB 4RAT "Effects Of Temperature On Protein Structure And Dynamics: X- Ray Crystallographic Studies Of The Protein Ribonuclease-A At Nine" 100.00 124 100.00 100.00 1.55e-85 PDB 4RSD "Structure Of The D121a Variant Of Ribonuclease A" 100.00 124 99.19 99.19 2.69e-84 PDB 4RSK "Structure Of The K7aR10AK66A VARIANT OF RIBONUCLEASE A Complexed With 3'-Ump" 100.00 124 97.58 97.58 9.13e-83 PDB 4RTE "The X-ray Structure Of Bovine Pancreatic Ribonuclease Incubated In The Presence Of An Excess Of Cisplatin (1:10 Ratio)" 100.00 124 100.00 100.00 1.55e-85 PDB 4SRN "Structural Changes That Accompany The Reduced Catalytic Efficiency Of Two Semisynthetic Ribonuclease Analogs" 91.13 113 100.00 100.00 5.36e-76 PDB 4YGW "Rnase S In Complex With Stabilized S Peptide" 83.06 103 100.00 100.00 9.97e-70 PDB 5RAT "Effects Of Temperature On Protein Structure And Dynamics: X- Ray Crystallographic Studies Of The Protein Ribonuclease-A At Nine" 100.00 124 100.00 100.00 1.55e-85 PDB 5RSA "Comparison Of Two Independently Refined Models Of Ribonuclease-A" 99.19 124 100.00 100.00 9.21e-85 PDB 6RAT "Effects Of Temperature On Protein Structure And Dynamics: X-Ray Crystallographic Studies Of The Protein Ribonuclease-A At Nine " 100.00 124 100.00 100.00 1.55e-85 PDB 6RSA "Nuclear Magnetic Resonance And Neutron Diffraction Studies Of The Complex Of RibonucleaseA With Uridine Vanadate, A Transition-" 100.00 124 100.00 100.00 1.55e-85 PDB 7RAT "Effects Of Temperature On Protein Structure And Dynamics: X- Ray Crystallographic Studies Of The Protein Ribonuclease-A At Nine" 100.00 124 100.00 100.00 1.55e-85 PDB 7RSA "Structure Of Phosphate-Free Ribonuclease A Refined At 1.26 Angstroms" 100.00 124 100.00 100.00 1.55e-85 PDB 8RAT "Effects Of Temperature On Protein Structure And Dynamics: X- Ray Crystallographic Studies Of The Protein Ribonuclease-A At Nine" 100.00 124 100.00 100.00 1.55e-85 PDB 8RSA "Crystal Structure Of Two Covalent Nucleoside Derivatives Of Ribonuclease A" 100.00 124 100.00 100.00 1.55e-85 PDB 9RAT "Effects Of Temperature On Protein Structure And Dynamics: X-Ray Crystallographic Studies Of The Protein Ribonuclease-A At Nine " 100.00 124 100.00 100.00 1.55e-85 PDB 9RSA "Crystal Structure Of Two Covalent Nucleoside Derivatives Of Ribonuclease A" 100.00 124 100.00 100.00 1.55e-85 EMBL CAA30263 "ribonuclease [Bos taurus]" 100.00 150 100.00 100.00 1.59e-86 EMBL CAA33801 "unnamed protein product [Bos taurus]" 100.00 125 100.00 100.00 1.52e-85 EMBL CAB37066 "artificial [synthetic construct]" 100.00 128 100.00 100.00 1.60e-85 GB AAA72269 "ribonuclease S [synthetic construct]" 83.87 105 100.00 100.00 2.60e-70 GB AAA72757 "RNase A [synthetic construct]" 100.00 156 100.00 100.00 2.77e-86 GB AAB35594 "ribonuclease A, partial [Bos taurus]" 100.00 128 100.00 100.00 1.50e-85 GB AAB36134 "pancreatic-type ribonuclease, partial [Bos taurus]" 100.00 124 100.00 100.00 1.55e-85 GB AAI49530 "RNASE1 protein [Bos taurus]" 100.00 150 100.00 100.00 1.59e-86 PIR JC5560 "pancreatic ribonuclease (EC 3.1.27.5) A - Aspergillus niger var. macrosporus" 100.00 124 100.00 100.00 1.55e-85 PIR NRBOB "pancreatic ribonuclease (EC 3.1.27.5) - American bison (tentative sequence)" 100.00 124 100.00 100.00 1.55e-85 PRF 630436A RNase 100.00 124 100.00 100.00 1.55e-85 REF NP_001014408 "ribonuclease pancreatic precursor [Bos taurus]" 100.00 150 100.00 100.00 1.59e-86 REF XP_005211519 "PREDICTED: ribonuclease pancreatic isoform X1 [Bos taurus]" 100.00 150 100.00 100.00 1.59e-86 REF XP_005901936 "PREDICTED: ribonuclease pancreatic [Bos mutus]" 100.00 150 99.19 100.00 5.44e-86 REF XP_010837737 "PREDICTED: ribonuclease pancreatic [Bison bison bison]" 100.00 150 100.00 100.00 1.59e-86 SP P61823 "RecName: Full=Ribonuclease pancreatic; AltName: Full=RNase 1; AltName: Full=RNase A; Flags: Precursor" 100.00 150 100.00 100.00 1.59e-86 SP P61824 "RecName: Full=Ribonuclease pancreatic; AltName: Full=RNase 1; AltName: Full=RNase A" 100.00 124 100.00 100.00 1.55e-85 TPE CDG32088 "TPA: ribonuclease A C2 [Bos taurus]" 100.00 215 100.00 100.00 1.98e-86 TPG DAA25470 "TPA: ribonuclease pancreatic precursor [Bos taurus]" 100.00 150 100.00 100.00 1.59e-86 stop_ save_ #################### # Natural source # #################### save_natural_source _Saveframe_category natural_source loop_ _Mol_label _Organism_name_common _NCBI_taxonomy_ID _Superkingdom _Kingdom _Genus _Species _Details $ribonuclease_A Cow 9913 Eukaryota Metazoa Bos taurus 'tissue: pancreas' stop_ save_ ######################### # Experimental source # ######################### save_experimental_source _Saveframe_category experimental_source loop_ _Mol_label _Production_method _Host_organism_name_common _Genus _Species _Strain _Vector_name $ribonuclease_A 'recombinant technology' . Escherichia coli . 'PET-22b (+)' stop_ save_ ##################################### # Sample contents and methodology # ##################################### ######################## # Sample description # ######################## save_sample_1 _Saveframe_category sample _Sample_type solution _Details '40% acetic acid' loop_ _Mol_label _Concentration_value _Concentration_value_units _Isotopic_labeling $ribonuclease_A 1.75 mM '[U-98% 13C; U-98% 15N]' H2O 60 % 'natural abundance' 'acetic acid' 40 % 'natural abundance' stop_ save_ ############################ # Computer software used # ############################ save_TOPSPIN _Saveframe_category software _Name TOPSPIN _Version . loop_ _Vendor _Address _Electronic_address 'Bruker Biospin' . . stop_ loop_ _Task processing stop_ _Details . save_ save_SPARKY _Saveframe_category software _Name SPARKY _Version . loop_ _Vendor _Address _Electronic_address Goddard . . stop_ loop_ _Task 'chemical shift assignment' stop_ _Details . save_ ######################### # Experimental detail # ######################### ################################## # NMR Spectrometer definitions # ################################## save_spectrometer_1 _Saveframe_category NMR_spectrometer _Manufacturer Bruker _Model 'Avance US2 NMR' _Field_strength 800 _Details . save_ ############################# # NMR applied experiments # ############################# save_2D_1H-1H_NOESY_1 _Saveframe_category NMR_applied_experiment _Experiment_name '2D 1H-1H NOESY' _Sample_label $sample_1 save_ save_2D_1H-15N_HSQC_2 _Saveframe_category NMR_applied_experiment _Experiment_name '2D 1H-15N HSQC' _Sample_label $sample_1 save_ save_2D_1H-13C_HSQC_3 _Saveframe_category NMR_applied_experiment _Experiment_name '2D 1H-13C HSQC' _Sample_label $sample_1 save_ save_3D_HNCO_4 _Saveframe_category NMR_applied_experiment _Experiment_name '3D HNCO' _Sample_label $sample_1 save_ save_3D_HNCA_5 _Saveframe_category NMR_applied_experiment _Experiment_name '3D HNCA' _Sample_label $sample_1 save_ save_3D_HNCACB_6 _Saveframe_category NMR_applied_experiment _Experiment_name '3D HNCACB' _Sample_label $sample_1 save_ save_3D_HN(CO)CA_7 _Saveframe_category NMR_applied_experiment _Experiment_name '3D HN(CO)CA' _Sample_label $sample_1 save_ save_3D_CBCA(CO)NH_8 _Saveframe_category NMR_applied_experiment _Experiment_name '3D CBCA(CO)NH' _Sample_label $sample_1 save_ save_3D_HNHA_9 _Saveframe_category NMR_applied_experiment _Experiment_name '3D HNHA' _Sample_label $sample_1 save_ save_3D_HACANH_10 _Saveframe_category NMR_applied_experiment _Experiment_name '3D HACANH' _Sample_label $sample_1 save_ save_2D_CB-edited_1H-15N_HSQC_11 _Saveframe_category NMR_applied_experiment _Experiment_name '2D CB-edited 1H-15N HSQC' _Sample_label $sample_1 save_ save_2D_CG-edited_1H-15N_HSQC_12 _Saveframe_category NMR_applied_experiment _Experiment_name '2D CG-edited 1H-15N HSQC' _Sample_label $sample_1 save_ ####################### # Sample conditions # ####################### save_sample_conditions_1 _Saveframe_category sample_conditions _Details . loop_ _Variable_type _Variable_value _Variable_value_error _Variable_value_units pH 2.0 0.1 pH pressure 1 . atm temperature 298 0.1 K stop_ save_ #################### # NMR parameters # #################### ############################## # Assigned chemical shifts # ############################## ################################ # Chemical shift referencing # ################################ save_chemical_shift_reference_1 _Saveframe_category chemical_shift_reference _Details . loop_ _Mol_common_name _Atom_type _Atom_isotope_number _Atom_group _Chem_shift_units _Chem_shift_value _Reference_method _Reference_type _External_reference_sample_geometry _External_reference_location _External_reference_axis _Indirect_shift_ratio DSS C 13 'methyl protons' ppm 0.00 . indirect . . . 0.251449530 DSS H 1 'methyl protons' ppm 0.00 internal direct . . . 1.000000000 DSS N 15 'methyl protons' ppm 0.00 . indirect . . . 0.101329118 stop_ save_ ################################### # Assigned chemical shift lists # ################################### ################################################################### # Chemical Shift Ambiguity Index Value Definitions # # # # The values other than 1 are used for those atoms with different # # chemical shifts that cannot be assigned to stereospecific atoms # # or to specific residues or chains. # # # # Index Value Definition # # # # 1 Unique (including isolated methyl protons, # # geminal atoms, and geminal methyl # # groups with identical chemical shifts) # # (e.g. ILE HD11, HD12, HD13 protons) # # 2 Ambiguity of geminal atoms or geminal methyl # # proton groups (e.g. ASP HB2 and HB3 # # protons, LEU CD1 and CD2 carbons, or # # LEU HD11, HD12, HD13 and HD21, HD22, # # HD23 methyl protons) # # 3 Aromatic atoms on opposite sides of # # symmetrical rings (e.g. TYR HE1 and HE2 # # protons) # # 4 Intraresidue ambiguities (e.g. LYS HG and # # HD protons or TRP HZ2 and HZ3 protons) # # 5 Interresidue ambiguities (LYS 12 vs. LYS 27) # # 6 Intermolecular ambiguities (e.g. ASP 31 CA # # in monomer 1 and ASP 31 CA in monomer 2 # # of an asymmetrical homodimer, duplex # # DNA assignments, or other assignments # # that may apply to atoms in one or more # # molecule in the molecular assembly) # # 9 Ambiguous, specific ambiguity not defined # # # ################################################################### save_assigned_chem_shift_list_1 _Saveframe_category assigned_chemical_shifts _Details . loop_ _Software_label $SPARKY stop_ loop_ _Experiment_label '2D 1H-15N HSQC' '3D HNCO' '3D HNCA' '3D HNCACB' '3D HN(CO)CA' '3D CBCA(CO)NH' '3D HNHA' '3D HACANH' stop_ loop_ _Sample_label $sample_1 stop_ _Sample_conditions_label $sample_conditions_1 _Chem_shift_reference_set_label $chemical_shift_reference_1 _Mol_system_component_name 'ribonuclease A' _Text_data_format . _Text_data . loop_ _Atom_shift_assign_ID _Residue_author_seq_code _Residue_seq_code _Residue_label _Atom_name _Atom_type _Chem_shift_value _Chem_shift_value_error _Chem_shift_ambiguity_code 1 1 1 LYS HA H 4.139 0.001 1 2 1 1 LYS C C 172.4 0.1 1 3 1 1 LYS CA C 55.78 0.01 1 4 1 1 LYS CB C 33.22 0.01 1 5 2 2 GLU H H 8.731 0.001 1 6 2 2 GLU HA H 4.599 0.001 1 7 2 2 GLU C C 175.7 0.1 1 8 2 2 GLU CA C 55.81 0.01 1 9 2 2 GLU CB C 29.31 0.01 1 10 2 2 GLU N N 122.9 0.1 1 11 3 3 THR H H 8.207 0.001 1 12 3 3 THR HA H 4.452 0.001 1 13 3 3 THR C C 174.4 0.1 1 14 3 3 THR CA C 61.41 0.01 1 15 3 3 THR CB C 70.40 0.01 1 16 3 3 THR N N 115.4 0.1 1 17 4 4 ALA H H 8.426 0.001 1 18 4 4 ALA HA H 4.293 0.001 1 19 4 4 ALA C C 178.0 0.1 1 20 4 4 ALA CA C 53.50 0.01 1 21 4 4 ALA CB C 18.81 0.01 1 22 4 4 ALA N N 125.2 0.1 1 23 5 5 ALA H H 8.147 0.001 1 24 5 5 ALA HA H 4.278 0.001 1 25 5 5 ALA C C 178.2 0.1 1 26 5 5 ALA CA C 53.50 0.01 1 27 5 5 ALA CB C 18.85 0.01 1 28 5 5 ALA N N 121.3 0.1 1 29 6 6 ALA H H 7.965 0.001 1 30 6 6 ALA HA H 4.242 0.001 1 31 6 6 ALA C C 178.6 0.1 1 32 6 6 ALA CA C 53.62 0.01 1 33 6 6 ALA CB C 18.86 0.01 1 34 6 6 ALA N N 121.6 0.1 1 35 7 7 LYS H H 7.986 0.001 1 36 7 7 LYS HA H 4.151 0.001 1 37 7 7 LYS C C 177.1 0.1 1 38 7 7 LYS CA C 57.80 0.01 1 39 7 7 LYS CB C 32.77 0.01 1 40 7 7 LYS N N 118.6 0.1 1 41 8 8 PHE H H 8.014 0.001 1 42 8 8 PHE HA H 4.579 0.001 1 43 8 8 PHE C C 176.7 0.1 1 44 8 8 PHE CA C 58.79 0.01 1 45 8 8 PHE CB C 39.31 0.01 1 46 8 8 PHE N N 118.9 0.1 1 47 9 9 GLU H H 8.148 0.001 1 48 9 9 GLU HA H 4.319 0.001 1 49 9 9 GLU C C 176.7 0.1 1 50 9 9 GLU CA C 58.67 0.01 1 51 9 9 GLU CB C 28.68 0.01 1 52 9 9 GLU N N 120.4 0.1 1 53 10 10 ARG H H 8.181 0.001 1 54 10 10 ARG HA H 4.274 0.001 1 55 10 10 ARG C C 176.8 0.1 1 56 10 10 ARG CA C 57.17 0.01 1 57 10 10 ARG CB C 30.47 0.01 1 58 10 10 ARG N N 120.5 0.1 1 59 11 11 GLN H H 8.172 0.001 1 60 11 11 GLN HA H 4.279 0.001 1 61 11 11 GLN C C 176.2 0.1 1 62 11 11 GLN CA C 56.66 0.01 1 63 11 11 GLN CB C 29.30 0.01 1 64 11 11 GLN N N 119.0 0.1 1 65 12 12 HIS H H 8.284 0.001 1 66 12 12 HIS HA H 4.687 0.001 1 67 12 12 HIS C C 174.5 0.1 1 68 12 12 HIS CA C 55.84 0.01 1 69 12 12 HIS CB C 28.74 0.01 1 70 12 12 HIS N N 117.8 0.1 1 71 13 13 MET H H 8.236 0.001 1 72 13 13 MET HA H 4.489 0.001 1 73 13 13 MET C C 176.0 0.1 1 74 13 13 MET CA C 56.12 0.01 1 75 13 13 MET CB C 33.01 0.01 1 76 13 13 MET N N 120.7 0.1 1 77 14 14 ASP H H 8.424 0.001 1 78 14 14 ASP HA H 4.801 0.001 1 79 14 14 ASP C C 175.3 0.1 1 80 14 14 ASP CA C 53.35 0.01 1 81 14 14 ASP CB C 38.39 0.01 1 82 14 14 ASP N N 119.8 0.1 1 83 15 15 SER H H 8.219 0.001 1 84 15 15 SER HA H 4.546 0.001 1 85 15 15 SER C C 174.8 0.1 1 86 15 15 SER CA C 58.73 0.01 1 87 15 15 SER CB C 63.86 0.01 1 88 15 15 SER N N 115.8 0.1 1 89 16 16 SER H H 8.281 0.001 1 90 16 16 SER HA H 4.577 0.001 1 91 16 16 SER C C 175.1 0.1 1 92 16 16 SER CA C 58.99 0.01 1 93 16 16 SER CB C 63.75 0.01 1 94 16 16 SER N N 117.2 0.1 1 95 17 17 THR H H 8.098 0.001 1 96 17 17 THR HA H 4.436 0.001 1 97 17 17 THR C C 175.0 0.1 1 98 17 17 THR CA C 62.38 0.01 1 99 17 17 THR CB C 69.61 0.01 1 100 17 17 THR N N 114.8 0.1 1 101 18 18 SER H H 8.189 0.001 1 102 18 18 SER HA H 4.504 0.001 1 103 18 18 SER C C 175.0 0.1 1 104 18 18 SER CA C 58.92 0.01 1 105 18 18 SER CB C 63.85 0.01 1 106 18 18 SER N N 117.4 0.1 1 107 19 19 ALA H H 8.257 0.001 1 108 19 19 ALA HA H 4.341 0.001 1 109 19 19 ALA C C 178.1 0.1 1 110 19 19 ALA CA C 53.44 0.01 1 111 19 19 ALA CB C 18.85 0.01 1 112 19 19 ALA N N 125.5 0.1 1 113 20 20 ALA H H 8.100 0.001 1 114 20 20 ALA HA H 4.336 0.001 1 115 20 20 ALA C C 178.3 0.1 1 116 20 20 ALA CA C 53.28 0.01 1 117 20 20 ALA CB C 18.86 0.01 1 118 20 20 ALA N N 121.5 0.1 1 119 21 21 SER H H 8.085 0.001 1 120 21 21 SER HA H 4.500 0.001 1 121 21 21 SER C C 175.4 0.1 1 122 21 21 SER CA C 59.18 0.01 1 123 21 21 SER CB C 63.82 0.01 1 124 21 21 SER N N 113.7 0.1 1 125 22 22 SER H H 8.218 0.001 1 126 22 22 SER HA H 4.520 0.001 1 127 22 22 SER C C 175.6 0.1 1 128 22 22 SER CA C 59.43 0.01 1 129 22 22 SER CB C 63.69 0.01 1 130 22 22 SER N N 117.2 0.1 1 131 23 23 SER H H 8.201 0.001 1 132 23 23 SER HA H 4.469 0.001 1 133 23 23 SER C C 175.0 0.1 1 134 23 23 SER CA C 59.53 0.01 1 135 23 23 SER CB C 63.58 0.01 1 136 23 23 SER N N 117.0 0.1 1 137 24 24 ASN H H 8.272 0.001 1 138 24 24 ASN HA H 4.736 0.001 1 139 24 24 ASN C C 176.1 0.1 1 140 24 24 ASN CA C 54.60 0.01 1 141 24 24 ASN CB C 38.73 0.01 1 142 24 24 ASN N N 120.5 0.1 1 143 25 25 TYR H H 8.192 0.001 1 144 25 25 TYR HA H 4.392 0.001 1 145 25 25 TYR C C 177.1 0.1 1 146 25 25 TYR CA C 60.57 0.01 1 147 25 25 TYR CB C 38.51 0.01 1 148 25 25 TYR N N 120.7 0.1 1 149 26 26 CYS H H 8.394 0.001 1 150 26 26 CYS HA H 4.492 0.001 1 151 26 26 CYS C C 176.0 0.1 1 152 26 26 CYS CA C 57.20 0.01 1 153 26 26 CYS N N 117.4 0.1 1 154 27 27 ASN H H 8.316 0.001 1 155 27 27 ASN CA C 55.49 0.01 1 156 27 27 ASN CB C 38.43 0.01 1 157 27 27 ASN N N 119.2 0.1 1 158 29 29 MET C C 177.9 0.1 1 159 29 29 MET CA C 57.35 0.01 1 160 29 29 MET CB C 32.03 0.01 1 161 30 30 MET H H 8.075 0.001 1 162 30 30 MET HA H 4.403 0.001 1 163 30 30 MET C C 177.5 0.1 1 164 30 30 MET CA C 57.06 0.01 1 165 30 30 MET CB C 32.42 0.01 1 166 30 30 MET N N 118.5 0.1 1 167 31 31 LYS H H 7.921 0.001 1 168 31 31 LYS HA H 4.253 0.001 1 169 31 31 LYS C C 177.4 0.1 1 170 31 31 LYS CA C 57.86 0.01 1 171 31 31 LYS CB C 32.66 0.01 1 172 31 31 LYS N N 119.4 0.1 1 173 32 32 SER H H 7.954 0.001 1 174 32 32 SER HA H 4.425 0.001 1 175 32 32 SER C C 175.3 0.1 1 176 32 32 SER CA C 59.47 0.01 1 177 32 32 SER CB C 63.77 0.01 1 178 32 32 SER N N 114.1 0.1 1 179 33 33 ARG H H 8.111 0.001 1 180 33 33 ARG HA H 4.326 0.001 1 181 33 33 ARG C C 176.4 0.1 1 182 33 33 ARG CA C 57.09 0.01 1 183 33 33 ARG CB C 30.39 0.01 1 184 33 33 ARG N N 121.6 0.1 1 185 34 34 ASN H H 8.239 0.001 1 186 34 34 ASN HA H 4.705 0.001 1 187 34 34 ASN C C 175.6 0.1 1 188 34 34 ASN CA C 53.93 0.01 1 189 34 34 ASN CB C 38.59 0.01 1 190 34 34 ASN N N 117.9 0.1 1 191 35 35 LEU H H 8.056 0.001 1 192 35 35 LEU HA H 4.414 0.001 1 193 35 35 LEU C C 177.7 0.1 1 194 35 35 LEU CA C 55.88 0.01 1 195 35 35 LEU CB C 42.20 0.01 1 196 35 35 LEU N N 121.0 0.1 1 197 36 36 THR H H 7.925 0.001 1 198 36 36 THR HA H 4.325 0.001 1 199 36 36 THR C C 175.0 0.1 1 200 36 36 THR CA C 62.65 0.01 1 201 36 36 THR CB C 69.74 0.01 1 202 36 36 THR N N 112.3 0.1 1 203 37 37 LYS H H 8.043 0.001 1 204 37 37 LYS HA H 4.535 0.001 1 205 37 37 LYS C C 176.4 0.1 1 206 37 37 LYS CA C 56.93 0.01 1 207 37 37 LYS CB C 32.69 0.01 1 208 37 37 LYS N N 121.4 0.1 1 209 38 38 ASP H H 8.194 0.001 1 210 38 38 ASP HA H 4.719 0.001 1 211 38 38 ASP C C 175.1 0.1 1 212 38 38 ASP CA C 53.40 0.01 1 213 38 38 ASP CB C 38.51 0.01 1 214 38 38 ASP N N 118.4 0.1 1 215 39 39 ARG H H 8.076 0.001 1 216 39 39 ARG C C 175.8 0.1 1 217 39 39 ARG CA C 56.22 0.01 1 218 39 39 ARG CB C 30.78 0.01 1 219 39 39 ARG N N 120.1 0.1 1 220 40 40 CYS H H 8.207 0.001 1 221 40 40 CYS C C 173.8 0.1 1 222 40 40 CYS CA C 54.91 0.01 1 223 40 40 CYS CB C 40.60 0.01 1 224 40 40 CYS N N 117.8 0.1 1 225 41 41 LYS H H 8.236 0.001 1 226 41 41 LYS HA H 4.678 0.001 1 227 41 41 LYS CA C 54.32 0.01 1 228 41 41 LYS CB C 32.91 0.01 1 229 41 41 LYS N N 123.4 0.1 1 230 42 42 PRO C C 176.6 0.1 1 231 42 42 PRO CA C 63.30 0.01 1 232 42 42 PRO CB C 31.96 0.01 1 233 43 43 VAL H H 8.078 0.001 1 234 43 43 VAL HA H 4.161 0.001 1 235 43 43 VAL C C 175.7 0.1 1 236 43 43 VAL CA C 62.20 0.01 1 237 43 43 VAL CB C 33.15 0.01 1 238 43 43 VAL N N 119.1 0.1 1 239 44 44 ASN H H 8.345 0.001 1 240 44 44 ASN HA H 4.806 0.001 1 241 44 44 ASN C C 175.3 0.1 1 242 44 44 ASN CA C 53.34 0.01 1 243 44 44 ASN CB C 38.83 0.01 1 244 44 44 ASN N N 121.2 0.1 1 245 45 45 THR H H 7.962 0.001 1 246 45 45 THR HA H 4.298 0.001 1 247 45 45 THR C C 174.3 0.1 1 248 45 45 THR CA C 62.26 0.01 1 249 45 45 THR CB C 69.59 0.01 1 250 45 45 THR N N 113.8 0.1 1 251 46 46 PHE H H 8.101 0.001 1 252 46 46 PHE HA H 4.655 0.001 1 253 46 46 PHE C C 175.9 0.1 1 254 46 46 PHE CA C 58.18 0.01 1 255 46 46 PHE CB C 39.20 0.01 1 256 46 46 PHE N N 121.3 0.1 1 257 47 47 VAL H H 7.876 0.001 1 258 47 47 VAL HA H 4.053 0.001 1 259 47 47 VAL C C 175.8 0.1 1 260 47 47 VAL CA C 62.74 0.01 1 261 47 47 VAL CB C 32.72 0.01 1 262 47 47 VAL N N 119.9 0.1 1 263 48 48 HIS H H 8.386 0.001 1 264 48 48 HIS HA H 4.713 0.001 1 265 48 48 HIS C C 174.3 0.1 1 266 48 48 HIS CA C 55.66 0.01 1 267 48 48 HIS CB C 28.72 0.01 1 268 48 48 HIS N N 120.7 0.1 1 269 49 49 GLU H H 8.273 0.001 1 270 49 49 GLU HA H 4.463 0.001 1 271 49 49 GLU C C 175.7 0.1 1 272 49 49 GLU CA C 56.03 0.01 1 273 49 49 GLU CB C 29.32 0.01 1 274 49 49 GLU N N 120.9 0.1 1 275 50 50 SER H H 8.306 0.001 1 276 50 50 SER HA H 4.556 0.001 1 277 50 50 SER C C 175.0 0.1 1 278 50 50 SER CA C 58.17 0.01 1 279 50 50 SER CB C 64.35 0.01 1 280 50 50 SER N N 117.0 0.1 1 281 51 51 LEU H H 8.355 0.001 1 282 51 51 LEU HA H 4.274 0.001 1 283 51 51 LEU C C 177.9 0.1 1 284 51 51 LEU CA C 56.70 0.01 1 285 51 51 LEU CB C 41.85 0.01 1 286 51 51 LEU N N 123.2 0.1 1 287 52 52 ALA H H 8.108 0.001 1 288 52 52 ALA HA H 4.258 0.001 1 289 52 52 ALA C C 178.7 0.1 1 290 52 52 ALA CA C 53.86 0.01 1 291 52 52 ALA CB C 18.57 0.01 1 292 52 52 ALA N N 121.4 0.1 1 293 53 53 ASP H H 8.007 0.001 1 294 53 53 ASP HA H 4.654 0.001 1 295 53 53 ASP C C 176.1 0.1 1 296 53 53 ASP CA C 54.46 0.01 1 297 53 53 ASP CB C 38.15 0.01 1 298 53 53 ASP N N 117.0 0.1 1 299 54 54 VAL H H 7.865 0.001 1 300 54 54 VAL HA H 3.956 0.001 1 301 54 54 VAL C C 176.9 0.1 1 302 54 54 VAL CA C 64.88 0.01 1 303 54 54 VAL CB C 32.14 0.01 1 304 54 54 VAL N N 119.7 0.1 1 305 55 55 GLN H H 8.293 0.001 1 306 55 55 GLN HA H 4.168 0.001 1 307 55 55 GLN C C 177.2 0.1 1 308 55 55 GLN CA C 57.79 0.01 1 309 55 55 GLN CB C 28.72 0.01 1 310 55 55 GLN N N 119.7 0.1 1 311 56 56 ALA H H 7.966 0.001 1 312 56 56 ALA HA H 4.322 0.001 1 313 56 56 ALA C C 179.0 0.1 1 314 56 56 ALA CA C 54.05 0.01 1 315 56 56 ALA CB C 18.85 0.01 1 316 56 56 ALA N N 122.6 0.1 1 317 57 57 VAL H H 7.987 0.001 1 318 57 57 VAL CA C 64.36 0.01 1 319 57 57 VAL N N 117.5 0.1 1 320 58 58 CYS C C 175.5 0.1 1 321 58 58 CYS CA C 56.04 0.01 1 322 59 59 SER H H 8.126 0.001 1 323 59 59 SER HA H 4.525 0.001 1 324 59 59 SER CA C 59.39 0.01 1 325 59 59 SER CB C 64.03 0.01 1 326 59 59 SER N N 115.5 0.1 1 327 60 60 GLN H H 8.059 0.001 1 328 60 60 GLN CA C 56.64 0.01 1 329 60 60 GLN CB C 29.20 0.01 1 330 60 60 GLN N N 121.2 0.1 1 331 61 61 LYS HA H 4.332 0.001 1 332 61 61 LYS C C 176.3 0.1 1 333 61 61 LYS CA C 56.74 0.01 1 334 61 61 LYS CB C 33.02 0.01 1 335 62 62 ASN H H 8.251 0.001 1 336 62 62 ASN HA H 4.786 0.001 1 337 62 62 ASN C C 175.3 0.1 1 338 62 62 ASN CA C 53.61 0.01 1 339 62 62 ASN CB C 38.95 0.01 1 340 62 62 ASN N N 118.7 0.1 1 341 63 63 VAL H H 7.946 0.001 1 342 63 63 VAL HA H 4.139 0.001 1 343 63 63 VAL C C 175.7 0.1 1 344 63 63 VAL CA C 62.68 0.01 1 345 63 63 VAL CB C 32.70 0.01 1 346 63 63 VAL N N 119.2 0.1 1 347 64 64 ALA H H 8.139 0.001 1 348 64 64 ALA HA H 4.398 0.001 1 349 64 64 ALA C C 177.6 0.1 1 350 64 64 ALA CA C 52.75 0.01 1 351 64 64 ALA CB C 19.33 0.01 1 352 64 64 ALA N N 125.3 0.1 1 353 65 65 CYS H H 8.140 0.001 1 354 65 65 CYS HA H 4.720 0.001 1 355 65 65 CYS C C 175.1 0.1 1 356 65 65 CYS CA C 55.31 0.01 1 357 65 65 CYS CB C 41.01 0.01 1 358 65 65 CYS N N 117.3 0.1 1 359 66 66 LYS H H 8.359 0.001 1 360 66 66 LYS HA H 4.375 0.001 1 361 66 66 LYS C C 176.3 0.1 1 362 66 66 LYS CA C 56.72 0.01 1 363 66 66 LYS CB C 33.12 0.01 1 364 66 66 LYS N N 122.8 0.1 1 365 67 67 ASN H H 8.295 0.001 1 366 67 67 ASN HA H 4.655 0.001 1 367 67 67 ASN C C 175.8 0.1 1 368 67 67 ASN CA C 53.87 0.01 1 369 67 67 ASN CB C 38.35 0.01 1 370 67 67 ASN N N 117.5 0.1 1 371 68 68 GLY H H 8.356 0.001 1 372 68 68 GLY HA2 H 3.820 0.001 2 373 68 68 GLY HA3 H 4.205 0.001 2 374 68 68 GLY C C 174.4 0.1 1 375 68 68 GLY CA C 45.69 0.01 1 376 68 68 GLY N N 109.4 0.1 1 377 69 69 GLN H H 8.062 0.001 1 378 69 69 GLN HA H 4.462 0.001 1 379 69 69 GLN C C 176.5 0.1 1 380 69 69 GLN CA C 56.16 0.01 1 381 69 69 GLN CB C 29.38 0.01 1 382 69 69 GLN N N 119.4 0.1 1 383 70 70 THR H H 8.185 0.001 1 384 70 70 THR HA H 4.335 0.001 1 385 70 70 THR C C 174.6 0.1 1 386 70 70 THR CA C 62.74 0.01 1 387 70 70 THR CB C 69.59 0.01 1 388 70 70 THR N N 113.3 0.1 1 389 71 71 ASN H H 8.336 0.001 1 390 71 71 ASN HA H 4.758 0.001 1 391 71 71 ASN C C 175.0 0.1 1 392 71 71 ASN CA C 53.49 0.01 1 393 71 71 ASN CB C 37.99 0.01 1 394 71 71 ASN N N 118.5 0.1 1 395 72 72 CYS H H 8.081 0.001 1 396 72 72 CYS HA H 4.613 0.001 1 397 72 72 CYS C C 174.1 0.1 1 398 72 72 CYS CA C 56.98 0.01 1 399 72 72 CYS CB C 41.40 0.01 1 400 72 72 CYS N N 117.8 0.1 1 401 73 73 TYR H H 8.113 0.001 1 402 73 73 TYR HA H 4.555 0.001 1 403 73 73 TYR C C 175.7 0.1 1 404 73 73 TYR CA C 58.42 0.01 1 405 73 73 TYR CB C 38.65 0.01 1 406 73 73 TYR N N 120.5 0.1 1 407 74 74 GLN H H 8.128 0.001 1 408 74 74 GLN HA H 4.365 0.001 1 409 74 74 GLN C C 175.7 0.1 1 410 74 74 GLN CA C 56.09 0.01 1 411 74 74 GLN CB C 29.71 0.01 1 412 74 74 GLN N N 120.7 0.1 1 413 75 75 SER H H 8.155 0.001 1 414 75 75 SER HA H 4.490 0.001 1 415 75 75 SER C C 174.2 0.1 1 416 75 75 SER CA C 58.51 0.01 1 417 75 75 SER CB C 63.89 0.01 1 418 75 75 SER N N 116.3 0.1 1 419 76 76 TYR H H 8.102 0.001 1 420 76 76 TYR HA H 4.638 0.001 1 421 76 76 TYR C C 176.1 0.1 1 422 76 76 TYR CA C 58.45 0.01 1 423 76 76 TYR CB C 38.79 0.01 1 424 76 76 TYR N N 121.4 0.1 1 425 77 77 SER H H 8.179 0.001 1 426 77 77 SER HA H 4.542 0.001 1 427 77 77 SER C C 174.9 0.1 1 428 77 77 SER CA C 58.70 0.01 1 429 77 77 SER CB C 63.95 0.01 1 430 77 77 SER N N 115.8 0.1 1 431 78 78 THR H H 8.074 0.001 1 432 78 78 THR HA H 4.400 0.001 1 433 78 78 THR C C 174.9 0.1 1 434 78 78 THR CA C 62.51 0.01 1 435 78 78 THR CB C 69.51 0.01 1 436 78 78 THR N N 115.1 0.1 1 437 79 79 MET H H 8.137 0.001 1 438 79 79 MET HA H 4.473 0.001 1 439 79 79 MET C C 176.1 0.1 1 440 79 79 MET CA C 56.25 0.01 1 441 79 79 MET CB C 33.15 0.01 1 442 79 79 MET N N 121.5 0.1 1 443 80 80 SER H H 8.135 0.001 1 444 80 80 SER HA H 4.527 0.001 1 445 80 80 SER C C 174.8 0.1 1 446 80 80 SER CA C 58.60 0.01 1 447 80 80 SER CB C 63.87 0.01 1 448 80 80 SER N N 115.9 0.1 1 449 81 81 ILE H H 8.043 0.001 1 450 81 81 ILE HA H 4.309 0.001 1 451 81 81 ILE C C 176.5 0.1 1 452 81 81 ILE CA C 62.07 0.01 1 453 81 81 ILE CB C 38.69 0.01 1 454 81 81 ILE N N 121.4 0.1 1 455 82 82 THR H H 7.989 0.001 1 456 82 82 THR HA H 4.365 0.001 1 457 82 82 THR C C 174.7 0.1 1 458 82 82 THR CA C 62.54 0.01 1 459 82 82 THR CB C 69.58 0.01 1 460 82 82 THR N N 115.4 0.1 1 461 83 83 ASP H H 8.232 0.001 1 462 83 83 ASP HA H 4.802 0.001 1 463 83 83 ASP C C 175.4 0.1 1 464 83 83 ASP CA C 53.50 0.01 1 465 83 83 ASP CB C 38.68 0.01 1 466 83 83 ASP N N 120.3 0.1 1 467 84 84 CYS H H 8.283 0.001 1 468 84 84 CYS HA H 4.597 0.001 1 469 84 84 CYS C C 175.0 0.1 1 470 84 84 CYS CA C 54.85 0.01 1 471 84 84 CYS CB C 39.94 0.01 1 472 84 84 CYS N N 118.2 0.1 1 473 85 85 ARG H H 8.233 0.001 1 474 85 85 ARG HA H 4.277 0.001 1 475 85 85 ARG C C 176.2 0.1 1 476 85 85 ARG CA C 54.94 0.01 1 477 85 85 ARG CB C 29.34 0.01 1 478 85 85 ARG N N 120.9 0.1 1 479 86 86 GLU H H 8.239 0.001 1 480 86 86 GLU C C 176.2 0.1 1 481 86 86 GLU CA C 56.00 0.01 1 482 86 86 GLU CB C 29.00 0.01 1 483 86 86 GLU N N 120.2 0.1 1 484 87 87 THR H H 8.107 0.001 1 485 87 87 THR HA H 4.431 0.001 1 486 87 87 THR C C 175.1 0.1 1 487 87 87 THR CA C 62.04 0.01 1 488 87 87 THR CB C 69.96 0.01 1 489 87 87 THR N N 113.7 0.1 1 490 88 88 GLY H H 8.326 0.001 1 491 88 88 GLY HA2 H 4.069 0.001 2 492 88 88 GLY C C 174.1 0.1 1 493 88 88 GLY CA C 45.57 0.01 1 494 88 88 GLY N N 110.3 0.1 1 495 89 89 SER H H 8.122 0.001 1 496 89 89 SER C C 174.7 0.1 1 497 89 89 SER CA C 58.33 0.01 1 498 89 89 SER CB C 64.14 0.01 1 499 89 89 SER N N 114.7 0.1 1 500 90 90 SER H H 8.220 0.001 1 501 90 90 SER HA H 4.485 0.001 1 502 90 90 SER C C 174.3 0.1 1 503 90 90 SER CA C 58.63 0.01 1 504 90 90 SER CB C 63.77 0.01 1 505 90 90 SER N N 117.2 0.1 1 506 91 91 LYS H H 8.063 0.001 1 507 91 91 LYS HA H 4.285 0.001 1 508 91 91 LYS C C 175.5 0.1 1 509 91 91 LYS CA C 56.41 0.01 1 510 91 91 LYS CB C 33.10 0.01 1 511 91 91 LYS N N 121.6 0.1 1 512 92 92 TYR H H 7.891 0.001 1 513 92 92 TYR HA H 4.887 0.001 1 514 92 92 TYR CA C 55.41 0.01 1 515 92 92 TYR CB C 38.49 0.01 1 516 92 92 TYR N N 119.8 0.1 1 517 93 93 PRO HA H 4.498 0.001 1 518 93 93 PRO C C 176.3 0.1 1 519 93 93 PRO CA C 63.25 0.01 1 520 93 93 PRO CB C 31.99 0.01 1 521 94 94 ASN H H 8.360 0.001 1 522 94 94 ASN HA H 4.816 0.001 1 523 94 94 ASN C C 175.4 0.1 1 524 94 94 ASN CA C 53.32 0.01 1 525 94 94 ASN CB C 38.85 0.01 1 526 94 94 ASN N N 118.3 0.1 1 527 95 95 CYS H H 8.348 0.001 1 528 95 95 CYS HA H 4.479 0.001 1 529 95 95 CYS C C 174.2 0.1 1 530 95 95 CYS CA C 55.40 0.01 1 531 95 95 CYS CB C 40.81 0.01 1 532 95 95 CYS N N 118.6 0.1 1 533 96 96 ALA H H 8.268 0.001 1 534 96 96 ALA HA H 4.396 0.001 1 535 96 96 ALA C C 177.0 0.1 1 536 96 96 ALA CA C 52.72 0.01 1 537 96 96 ALA CB C 19.17 0.01 1 538 96 96 ALA N N 124.5 0.1 1 539 97 97 TYR H H 7.945 0.001 1 540 97 97 TYR HA H 4.622 0.001 1 541 97 97 TYR C C 175.7 0.1 1 542 97 97 TYR CA C 58.06 0.01 1 543 97 97 TYR CB C 38.58 0.01 1 544 97 97 TYR N N 119.0 0.1 1 545 98 98 LYS H H 8.185 0.001 1 546 98 98 LYS C C 176.5 0.1 1 547 98 98 LYS CA C 56.47 0.01 1 548 98 98 LYS N N 119.1 0.1 1 549 99 99 THR H H 8.103 0.001 1 550 99 99 THR HA H 4.436 0.001 1 551 99 99 THR C C 174.8 0.1 1 552 99 99 THR CA C 62.03 0.01 1 553 99 99 THR CB C 69.85 0.01 1 554 99 99 THR N N 114.5 0.1 1 555 100 100 THR H H 8.121 0.001 1 556 100 100 THR HA H 4.537 0.001 1 557 100 100 THR C C 174.8 0.1 1 558 100 100 THR CA C 62.26 0.01 1 559 100 100 THR CB C 69.72 0.01 1 560 100 100 THR N N 115.1 0.1 1 561 101 101 GLN H H 8.274 0.001 1 562 101 101 GLN HA H 4.351 0.001 1 563 101 101 GLN C C 176.0 0.1 1 564 101 101 GLN CA C 56.43 0.01 1 565 101 101 GLN CB C 29.33 0.01 1 566 101 101 GLN N N 121.1 0.1 1 567 102 102 ALA H H 8.171 0.001 1 568 102 102 ALA HA H 4.305 0.001 1 569 102 102 ALA C C 177.5 0.1 1 570 102 102 ALA CA C 53.16 0.01 1 571 102 102 ALA CB C 19.02 0.01 1 572 102 102 ALA N N 123.6 0.1 1 573 103 103 ASN H H 8.170 0.001 1 574 103 103 ASN HA H 4.683 0.001 1 575 103 103 ASN C C 175.4 0.1 1 576 103 103 ASN CA C 53.52 0.01 1 577 103 103 ASN CB C 38.67 0.01 1 578 103 103 ASN N N 116.6 0.1 1 579 104 104 LYS H H 8.077 0.001 1 580 104 104 LYS HA H 4.281 0.001 1 581 104 104 LYS C C 176.3 0.1 1 582 104 104 LYS CA C 56.84 0.01 1 583 104 104 LYS CB C 32.87 0.01 1 584 104 104 LYS N N 120.2 0.1 1 585 105 105 HIS H H 8.333 0.001 1 586 105 105 HIS HA H 4.758 0.001 1 587 105 105 HIS C C 174.2 0.1 1 588 105 105 HIS CA C 55.62 0.01 1 589 105 105 HIS CB C 28.93 0.01 1 590 105 105 HIS N N 117.6 0.1 1 591 106 106 ILE H H 8.015 0.001 1 592 106 106 ILE HA H 4.198 0.001 1 593 106 106 ILE C C 175.5 0.1 1 594 106 106 ILE CA C 61.44 0.01 1 595 106 106 ILE CB C 38.38 0.01 1 596 106 106 ILE N N 120.8 0.1 1 597 107 107 ILE H H 8.100 0.001 1 598 107 107 ILE HA H 4.220 0.001 1 599 107 107 ILE C C 176.0 0.1 1 600 107 107 ILE CA C 61.37 0.01 1 601 107 107 ILE CB C 38.55 0.01 1 602 107 107 ILE N N 124.0 0.1 1 603 108 108 VAL H H 8.119 0.001 1 604 108 108 VAL HA H 4.454 0.001 1 605 108 108 VAL C C 175.5 0.1 1 606 108 108 VAL CA C 62.30 0.01 1 607 108 108 VAL CB C 32.81 0.01 1 608 108 108 VAL N N 123.0 0.1 1 609 109 109 ALA H H 8.183 0.001 1 610 109 109 ALA HA H 4.498 0.001 1 611 109 109 ALA C C 177.5 0.1 1 612 109 109 ALA CA C 52.44 0.01 1 613 109 109 ALA CB C 19.46 0.01 1 614 109 109 ALA N N 126.1 0.1 1 615 110 110 CYS H H 8.293 0.001 1 616 110 110 CYS HA H 4.745 0.001 1 617 110 110 CYS C C 174.7 0.1 1 618 110 110 CYS CA C 53.92 0.01 1 619 110 110 CYS CB C 38.63 0.01 1 620 110 110 CYS N N 117.2 0.1 1 621 111 111 GLU H H 8.057 0.001 1 622 111 111 GLU HA H 4.462 0.001 1 623 111 111 GLU C C 176.0 0.1 1 624 111 111 GLU CA C 55.95 0.01 1 625 111 111 GLU CB C 29.14 0.01 1 626 111 111 GLU N N 121.2 0.1 1 627 112 112 GLY H H 8.213 0.001 1 628 112 112 GLY HA2 H 3.982 0.001 2 629 112 112 GLY C C 173.0 0.1 1 630 112 112 GLY CA C 45.08 0.01 1 631 112 112 GLY N N 108.7 0.1 1 632 113 113 ASN H H 8.153 0.001 1 633 113 113 ASN HA H 5.018 0.001 1 634 113 113 ASN CA C 51.03 0.01 1 635 113 113 ASN CB C 39.26 0.01 1 636 113 113 ASN N N 118.8 0.1 1 637 114 114 PRO HA H 4.456 0.001 1 638 114 114 PRO C C 176.1 0.1 1 639 114 114 PRO CA C 63.40 0.01 1 640 114 114 PRO CB C 31.97 0.01 1 641 115 115 TYR H H 8.075 0.001 1 642 115 115 TYR HA H 4.574 0.001 1 643 115 115 TYR C C 175.1 0.1 1 644 115 115 TYR CA C 57.94 0.01 1 645 115 115 TYR CB C 38.52 0.01 1 646 115 115 TYR N N 119.3 0.1 1 647 116 116 VAL H H 7.631 0.001 1 648 116 116 VAL HA H 4.395 0.001 1 649 116 116 VAL CA C 59.36 0.01 1 650 116 116 VAL CB C 33.15 0.01 1 651 116 116 VAL N N 122.7 0.1 1 652 117 117 PRO HA H 4.430 0.001 1 653 117 117 PRO C C 176.3 0.1 1 654 117 117 PRO CA C 63.03 0.01 1 655 117 117 PRO CB C 31.91 0.01 1 656 118 118 VAL H H 7.868 0.001 1 657 118 118 VAL HA H 4.083 0.001 1 658 118 118 VAL C C 175.6 0.1 1 659 118 118 VAL CA C 62.05 0.01 1 660 118 118 VAL CB C 33.02 0.01 1 661 118 118 VAL N N 119.0 0.1 1 662 119 119 HIS H H 8.283 0.001 1 663 119 119 HIS HA H 4.781 0.001 1 664 119 119 HIS C C 173.6 0.1 1 665 119 119 HIS CA C 54.80 0.01 1 666 119 119 HIS CB C 29.33 0.01 1 667 119 119 HIS N N 120.8 0.1 1 668 120 120 PHE H H 8.228 0.001 1 669 120 120 PHE HA H 4.648 0.001 1 670 120 120 PHE C C 175.1 0.1 1 671 120 120 PHE CA C 57.76 0.01 1 672 120 120 PHE CB C 39.89 0.01 1 673 120 120 PHE N N 121.8 0.1 1 674 121 121 ASP H H 8.333 0.001 1 675 121 121 ASP HA H 4.725 0.001 1 676 121 121 ASP C C 174.2 0.1 1 677 121 121 ASP CA C 52.74 0.01 1 678 121 121 ASP CB C 38.31 0.01 1 679 121 121 ASP N N 120.8 0.1 1 680 122 122 ALA H H 8.078 0.001 1 681 122 122 ALA HA H 4.391 0.001 1 682 122 122 ALA C C 177.1 0.1 1 683 122 122 ALA CA C 52.51 0.01 1 684 122 122 ALA CB C 19.44 0.01 1 685 122 122 ALA N N 124.2 0.1 1 686 123 123 SER H H 8.103 0.001 1 687 123 123 SER HA H 4.561 0.001 1 688 123 123 SER C C 174.0 0.1 1 689 123 123 SER CA C 58.29 0.01 1 690 123 123 SER CB C 63.96 0.01 1 691 123 123 SER N N 114.4 0.1 1 692 124 124 VAL H H 7.856 0.001 1 693 124 124 VAL HA H 4.329 0.001 1 694 124 124 VAL CA C 61.07 0.01 1 695 124 124 VAL CB C 32.91 0.01 1 696 124 124 VAL N N 119.4 0.1 1 stop_ save_