data_25696 ####################### # Entry information # ####################### save_entry_information _Saveframe_category entry_information _Entry_title ; human CFTR NBD1 deltaRI chemical shift assignments ; _BMRB_accession_number 25696 _BMRB_flat_file_name bmr25696.str _Entry_type original _Submission_date 2015-07-09 _Accession_date 2015-07-09 _Entry_origination author _NMR_STAR_version 2.1.1 _Experimental_method NMR _Details 'chemical shift assignments for a protein construct comprising residues 387-404 and 437-646 of human CFTR' loop_ _Author_ordinal _Author_family_name _Author_given_name _Author_middle_initials _Author_family_title 1 Chong Andrew . . 2 Forman-Kay Julie D. . stop_ loop_ _Saveframe_category_type _Saveframe_category_type_count assigned_chemical_shifts 1 stop_ loop_ _Data_type _Data_type_count "1H chemical shifts" 201 "13C chemical shifts" 585 "15N chemical shifts" 201 stop_ loop_ _Revision_date _Revision_keyword _Revision_author _Revision_detail 2016-08-12 update BMRB 'update entry citation' 2015-08-12 original author 'original release' stop_ loop_ _Related_BMRB_accession_number _Relationship 25697 'hCFTR NBD1 deltaRI I539T' 25698 'hCFTR NBD1 deltaRI F508del' stop_ _Original_release_date 2015-08-12 save_ ############################# # Citation for this entry # ############################# save_entry_citation _Saveframe_category entry_citation _Citation_full . _Citation_title ; Deletion of Phenylalanine-508 in the First Nucleotide Binding Domain of the Cystic Fibrosis Transmembrane Conductance Regulator Increases Conformational Exchange and Inhibits Dimerization ; _Citation_status published _Citation_type journal _CAS_abstract_code . _MEDLINE_UI_code . _PubMed_ID 26149808 loop_ _Author_ordinal _Author_family_name _Author_given_name _Author_middle_initials _Author_family_title 1 Chong Andrew . . 2 Farber Patrick J. . 3 Vernon Robert M. . 4 Hudson Rhea P. . 5 Mittermaier Anthony K. . 6 Forman-Kay Julie D. . stop_ _Journal_abbreviation 'J. Biol. Chem.' _Journal_volume 290 _Journal_issue 38 _Journal_CSD . _Book_chapter_title . _Book_volume . _Book_series . _Book_ISBN . _Conference_state_province . _Conference_abstract_number . _Page_first 22862 _Page_last 22878 _Year 2015 _Details . save_ ################################## # Molecular system description # ################################## save_assembly _Saveframe_category molecular_system _Mol_system_name 'hCFTR NBD1 deltaRI' _Enzyme_commission_number . loop_ _Mol_system_component_name _Mol_label 'hCFTR NBD1 delta RI' $hCFTR_NBD1_delta_RI stop_ _System_molecular_weight . _System_physical_state native _System_oligomer_state ? _System_paramagnetic no _System_thiol_state . _Database_query_date . _Details . save_ ######################## # Monomeric polymers # ######################## save_hCFTR_NBD1_delta_RI _Saveframe_category monomeric_polymer _Mol_type polymer _Mol_polymer_class protein _Name_common hCFTR_NBD1_delta_RI _Molecular_mass . _Mol_thiol_state 'not reported' _Details . ############################## # Polymer residue sequence # ############################## _Residue_count 229 _Mol_residue_sequence ; SLTTTEVVMENVTAFWEEGG TPVLKDINFKIERGQLLAVA GSTGAGKTSLLMMIMGELEP SEGKIKHSGRISFCSQFSWI MPGTIKENIIFGVSYDEYRY RSVIKACQLEEDISKFAEKD NIVLGEGGITLSGGQRARIS LARAVYKDADLYLLDSPFGY LDVLTEKEIFESCVCKLMAN KTRILVTSKMEHLKKADKIL ILHEGSSYFYGTFSELQNLQ PDFSSKLMG ; loop_ _Residue_seq_code _Residue_author_seq_code _Residue_label 1 386 SER 2 387 LEU 3 388 THR 4 389 THR 5 390 THR 6 391 GLU 7 392 VAL 8 393 VAL 9 394 MET 10 395 GLU 11 396 ASN 12 397 VAL 13 398 THR 14 399 ALA 15 400 PHE 16 401 TRP 17 402 GLU 18 403 GLU 19 404 GLY 20 437 GLY 21 438 THR 22 439 PRO 23 440 VAL 24 441 LEU 25 442 LYS 26 443 ASP 27 444 ILE 28 445 ASN 29 446 PHE 30 447 LYS 31 448 ILE 32 449 GLU 33 450 ARG 34 451 GLY 35 452 GLN 36 453 LEU 37 454 LEU 38 455 ALA 39 456 VAL 40 457 ALA 41 458 GLY 42 459 SER 43 460 THR 44 461 GLY 45 462 ALA 46 463 GLY 47 464 LYS 48 465 THR 49 466 SER 50 467 LEU 51 468 LEU 52 469 MET 53 470 MET 54 471 ILE 55 472 MET 56 473 GLY 57 474 GLU 58 475 LEU 59 476 GLU 60 477 PRO 61 478 SER 62 479 GLU 63 480 GLY 64 481 LYS 65 482 ILE 66 483 LYS 67 484 HIS 68 485 SER 69 486 GLY 70 487 ARG 71 488 ILE 72 489 SER 73 490 PHE 74 491 CYS 75 492 SER 76 493 GLN 77 494 PHE 78 495 SER 79 496 TRP 80 497 ILE 81 498 MET 82 499 PRO 83 500 GLY 84 501 THR 85 502 ILE 86 503 LYS 87 504 GLU 88 505 ASN 89 506 ILE 90 507 ILE 91 508 PHE 92 509 GLY 93 510 VAL 94 511 SER 95 512 TYR 96 513 ASP 97 514 GLU 98 515 TYR 99 516 ARG 100 517 TYR 101 518 ARG 102 519 SER 103 520 VAL 104 521 ILE 105 522 LYS 106 523 ALA 107 524 CYS 108 525 GLN 109 526 LEU 110 527 GLU 111 528 GLU 112 529 ASP 113 530 ILE 114 531 SER 115 532 LYS 116 533 PHE 117 534 ALA 118 535 GLU 119 536 LYS 120 537 ASP 121 538 ASN 122 539 ILE 123 540 VAL 124 541 LEU 125 542 GLY 126 543 GLU 127 544 GLY 128 545 GLY 129 546 ILE 130 547 THR 131 548 LEU 132 549 SER 133 550 GLY 134 551 GLY 135 552 GLN 136 553 ARG 137 554 ALA 138 555 ARG 139 556 ILE 140 557 SER 141 558 LEU 142 559 ALA 143 560 ARG 144 561 ALA 145 562 VAL 146 563 TYR 147 564 LYS 148 565 ASP 149 566 ALA 150 567 ASP 151 568 LEU 152 569 TYR 153 570 LEU 154 571 LEU 155 572 ASP 156 573 SER 157 574 PRO 158 575 PHE 159 576 GLY 160 577 TYR 161 578 LEU 162 579 ASP 163 580 VAL 164 581 LEU 165 582 THR 166 583 GLU 167 584 LYS 168 585 GLU 169 586 ILE 170 587 PHE 171 588 GLU 172 589 SER 173 590 CYS 174 591 VAL 175 592 CYS 176 593 LYS 177 594 LEU 178 595 MET 179 596 ALA 180 597 ASN 181 598 LYS 182 599 THR 183 600 ARG 184 601 ILE 185 602 LEU 186 603 VAL 187 604 THR 188 605 SER 189 606 LYS 190 607 MET 191 608 GLU 192 609 HIS 193 610 LEU 194 611 LYS 195 612 LYS 196 613 ALA 197 614 ASP 198 615 LYS 199 616 ILE 200 617 LEU 201 618 ILE 202 619 LEU 203 620 HIS 204 621 GLU 205 622 GLY 206 623 SER 207 624 SER 208 625 TYR 209 626 PHE 210 627 TYR 211 628 GLY 212 629 THR 213 630 PHE 214 631 SER 215 632 GLU 216 633 LEU 217 634 GLN 218 635 ASN 219 636 LEU 220 637 GLN 221 638 PRO 222 639 ASP 223 640 PHE 224 641 SER 225 642 SER 226 643 LYS 227 644 LEU 228 645 MET 229 646 GLY stop_ _Sequence_homology_query_date . _Sequence_homology_query_revised_last_date . save_ #################### # Natural source # #################### save_natural_source _Saveframe_category natural_source loop_ _Mol_label _Organism_name_common _NCBI_taxonomy_ID _Superkingdom _Kingdom _Genus _Species $hCFTR_NBD1_delta_RI human 9606 Eukaryota Metazoa Homo sapiens stop_ save_ ######################### # Experimental source # ######################### save_experimental_source _Saveframe_category experimental_source loop_ _Mol_label _Production_method _Host_organism_name_common _Genus _Species _Strain _Vector_name $hCFTR_NBD1_delta_RI 'recombinant technology' . Escherichia coli . 'pET-SUMO hNBD1 deltaRI WT' stop_ save_ ##################################### # Sample contents and methodology # ##################################### ######################## # Sample description # ######################## save_sample_1 _Saveframe_category sample _Sample_type solution _Details . loop_ _Mol_label _Concentration_value _Concentration_value_units _Isotopic_labeling $hCFTR_NBD1_delta_RI 1 mM '[U-99% 13C; U-99% 15N; 50% 2H ]' 'sodium phosphate' 50 mM 'natural abundance' 'sodium chloride' 150 mM 'natural abundance' glycerol 274 mM 'natural abundance' 'magnesium chloride' 5 mM 'natural abundance' 'sodium azide' .08 mM 'natural abundance' DTT 5 mM 'natural abundance' 'adenosine triphosphate' 5 mM 'natural abundance' H2O 90 % 'natural abundance' D2O 10 % 'natural abundance' stop_ save_ ############################ # Computer software used # ############################ save_NMRView _Saveframe_category software _Name NMRView _Version 5.2.2 loop_ _Vendor _Address _Electronic_address 'Johnson, One Moon Scientific' . . stop_ loop_ _Task 'chemical shift assignment' stop_ _Details . save_ ######################### # Experimental detail # ######################### ################################## # NMR Spectrometer definitions # ################################## save_spectrometer_1 _Saveframe_category NMR_spectrometer _Manufacturer Varian _Model INOVA _Field_strength 600 _Details 'with cryoprobe' save_ ############################# # NMR applied experiments # ############################# save_3D_HNCA_1 _Saveframe_category NMR_applied_experiment _Experiment_name '3D HNCA' _Sample_label $sample_1 save_ save_3D_HN(CO)CA_2 _Saveframe_category NMR_applied_experiment _Experiment_name '3D HN(CO)CA' _Sample_label $sample_1 save_ save_3D_HNCO_3 _Saveframe_category NMR_applied_experiment _Experiment_name '3D HNCO' _Sample_label $sample_1 save_ save_3D_HCACO_4 _Saveframe_category NMR_applied_experiment _Experiment_name '3D HCACO' _Sample_label $sample_1 save_ ####################### # Sample conditions # ####################### save_sample_conditions_1 _Saveframe_category sample_conditions _Details . loop_ _Variable_type _Variable_value _Variable_value_error _Variable_value_units pH 7.6 . pH pressure 1 . atm temperature 293.15 . K stop_ save_ #################### # NMR parameters # #################### ############################## # Assigned chemical shifts # ############################## ################################ # Chemical shift referencing # ################################ save_chemical_shift_reference_1 _Saveframe_category chemical_shift_reference _Details . loop_ _Mol_common_name _Atom_type _Atom_isotope_number _Atom_group _Chem_shift_units _Chem_shift_value _Reference_method _Reference_type _External_reference_sample_geometry _External_reference_location _External_reference_axis _Indirect_shift_ratio DSS C 13 'methyl protons' ppm 0.0 external indirect . . . 0.25148 DSS H 1 'methyl protons' ppm 0.0 external direct . . . 1 DSS N 15 'methyl protons' ppm 0.0 external indirect . . . 0.10134 stop_ save_ ################################### # Assigned chemical shift lists # ################################### ################################################################### # Chemical Shift Ambiguity Index Value Definitions # # # # The values other than 1 are used for those atoms with different # # chemical shifts that cannot be assigned to stereospecific atoms # # or to specific residues or chains. # # # # Index Value Definition # # # # 1 Unique (including isolated methyl protons, # # geminal atoms, and geminal methyl # # groups with identical chemical shifts) # # (e.g. ILE HD11, HD12, HD13 protons) # # 2 Ambiguity of geminal atoms or geminal methyl # # proton groups (e.g. ASP HB2 and HB3 # # protons, LEU CD1 and CD2 carbons, or # # LEU HD11, HD12, HD13 and HD21, HD22, # # HD23 methyl protons) # # 3 Aromatic atoms on opposite sides of # # symmetrical rings (e.g. TYR HE1 and HE2 # # protons) # # 4 Intraresidue ambiguities (e.g. LYS HG and # # HD protons or TRP HZ2 and HZ3 protons) # # 5 Interresidue ambiguities (LYS 12 vs. LYS 27) # # 6 Intermolecular ambiguities (e.g. ASP 31 CA # # in monomer 1 and ASP 31 CA in monomer 2 # # of an asymmetrical homodimer, duplex # # DNA assignments, or other assignments # # that may apply to atoms in one or more # # molecule in the molecular assembly) # # 9 Ambiguous, specific ambiguity not defined # # # ################################################################### save_assigned_chem_shift_list_1 _Saveframe_category assigned_chemical_shifts _Details . loop_ _Software_label $NMRView stop_ loop_ _Experiment_label '3D HNCA' '3D HN(CO)CA' '3D HNCO' '3D HCACO' stop_ loop_ _Sample_label $sample_1 stop_ _Sample_conditions_label $sample_conditions_1 _Chem_shift_reference_set_label $chemical_shift_reference_1 _Mol_system_component_name 'hCFTR NBD1 delta RI' _Text_data_format . _Text_data . loop_ _Atom_shift_assign_ID _Residue_author_seq_code _Residue_seq_code _Residue_label _Atom_name _Atom_type _Chem_shift_value _Chem_shift_value_error _Chem_shift_ambiguity_code 1 387 2 LEU C C 177.30 . . 2 387 2 LEU CA C 54.833 . . 3 387 2 LEU CB C 41.403 . . 4 387 2 LEU CD1 C 23.704 . . 5 388 3 THR H H 8.268 . . 6 388 3 THR C C 174.06 . . 7 388 3 THR CA C 61.043 . . 8 388 3 THR CB C 69.265 . . 9 388 3 THR CG2 C 20.977 . . 10 388 3 THR N N 115.40 . . 11 389 4 THR H H 8.264 . . 12 389 4 THR C C 173.48 . . 13 389 4 THR CA C 61.055 . . 14 389 4 THR CB C 69.000 . . 15 389 4 THR N N 116.21 . . 16 392 7 VAL C C 173.69 . . 17 392 7 VAL CA C 60.476 . . 18 392 7 VAL CG2 C 21.430 . . 19 393 8 VAL H H 8.671 . . 20 393 8 VAL C C 174.05 . . 21 393 8 VAL CA C 60.176 . . 22 393 8 VAL CB C 35.068 . . 23 393 8 VAL CG2 C 20.749 . . 24 393 8 VAL N N 125.34 . . 25 394 9 MET H H 8.287 . . 26 394 9 MET C C 174.19 . . 27 394 9 MET CA C 55.338 . . 28 394 9 MET CB C 32.630 . . 29 394 9 MET N N 123.64 . . 30 395 10 GLU H H 8.902 . . 31 395 10 GLU CA C 53.821 . . 32 395 10 GLU CB C 31.412 . . 33 395 10 GLU CG C 35.635 . . 34 395 10 GLU N N 124.87 . . 35 396 11 ASN H H 8.861 . . 36 396 11 ASN C C 174.19 . . 37 396 11 ASN CA C 53.716 . . 38 396 11 ASN CB C 37.929 . . 39 396 11 ASN N N 124.02 . . 40 397 12 VAL H H 8.329 . . 41 397 12 VAL C C 176.12 . . 42 397 12 VAL CA C 63.158 . . 43 397 12 VAL CB C 32.036 . . 44 397 12 VAL CG1 C 24.034 . . 45 397 12 VAL CG2 C 21.839 . . 46 397 12 VAL N N 119.86 . . 47 398 13 THR H H 7.799 . . 48 398 13 THR C C 172.57 . . 49 398 13 THR CA C 60.308 . . 50 398 13 THR CB C 71.820 . . 51 398 13 THR CG2 C 20.898 . . 52 398 13 THR N N 123.08 . . 53 399 14 ALA H H 8.783 . . 54 399 14 ALA C C 173.58 . . 55 399 14 ALA CA C 50.678 . . 56 399 14 ALA CB C 24.348 . . 57 399 14 ALA N N 126.91 . . 58 400 15 PHE H H 9.207 . . 59 400 15 PHE C C 174.86 . . 60 400 15 PHE CA C 56.301 . . 61 400 15 PHE CB C 41.280 . . 62 400 15 PHE N N 118.54 . . 63 401 16 TRP H H 8.901 . . 64 401 16 TRP HE1 H 9.351 . . 65 401 16 TRP C C 176.85 . . 66 401 16 TRP CA C 58.613 . . 67 401 16 TRP N N 121.01 . . 68 401 16 TRP NE1 N 126.16 . . 69 402 17 GLU H H 7.945 . . 70 402 17 GLU C C 175.29 . . 71 402 17 GLU CA C 53.990 . . 72 402 17 GLU CB C 32.800 . . 73 402 17 GLU CG C 35.428 . . 74 402 17 GLU N N 117.82 . . 75 403 18 GLU H H 8.777 . . 76 403 18 GLU C C 177.46 . . 77 403 18 GLU CA C 57.149 . . 78 403 18 GLU CB C 28.400 . . 79 403 18 GLU CG C 35.323 . . 80 403 18 GLU N N 125.44 . . 81 404 19 GLY H H 8.466 . . 82 404 19 GLY C C 174.21 . . 83 404 19 GLY CA C 44.704 . . 84 404 19 GLY N N 113.12 . . 85 437 20 GLY H H 7.943 . . 86 437 20 GLY C C 173.35 . . 87 437 20 GLY CA C 43.820 . . 88 437 20 GLY N N 108.23 . . 89 438 21 THR H H 8.585 . . 90 438 21 THR C C 172.46 . . 91 438 21 THR CA C 59.299 . . 92 438 21 THR CB C 69.270 . . 93 438 21 THR N N 118.04 . . 94 439 22 PRO C C 176.34 . . 95 439 22 PRO CA C 62.932 . . 96 440 23 VAL H H 8.232 . . 97 440 23 VAL C C 172.69 . . 98 440 23 VAL CA C 60.880 . . 99 440 23 VAL CB C 27.600 . . 100 440 23 VAL N N 122.67 . . 101 441 24 LEU H H 6.807 . . 102 441 24 LEU C C 175.23 . . 103 441 24 LEU CA C 52.506 . . 104 441 24 LEU CB C 45.612 . . 105 441 24 LEU N N 119.30 . . 106 442 25 LYS H H 8.511 . . 107 442 25 LYS C C 172.67 . . 108 442 25 LYS CA C 54.440 . . 109 442 25 LYS CB C 34.856 . . 110 442 25 LYS CG C 24.045 . . 111 442 25 LYS CD C 28.136 . . 112 442 25 LYS N N 121.71 . . 113 443 26 ASP H H 7.887 . . 114 443 26 ASP C C 173.17 . . 115 443 26 ASP CA C 54.406 . . 116 443 26 ASP CB C 39.148 . . 117 443 26 ASP N N 125.22 . . 118 444 27 ILE H H 9.230 . . 119 444 27 ILE C C 175.68 . . 120 444 27 ILE CA C 58.995 . . 121 444 27 ILE CB C 34.750 . . 122 444 27 ILE CG2 C 18.249 . . 123 444 27 ILE N N 119.39 . . 124 445 28 ASN H H 7.675 . . 125 445 28 ASN C C 173.96 . . 126 445 28 ASN CA C 51.850 . . 127 445 28 ASN CB C 42.689 . . 128 445 28 ASN N N 122.55 . . 129 446 29 PHE H H 8.265 . . 130 446 29 PHE C C 172.04 . . 131 446 29 PHE CA C 57.842 . . 132 446 29 PHE CB C 39.095 . . 133 446 29 PHE N N 114.38 . . 134 447 30 LYS H H 7.805 . . 135 447 30 LYS C C 174.63 . . 136 447 30 LYS CA C 55.181 . . 137 447 30 LYS CB C 34.909 . . 138 447 30 LYS N N 118.41 . . 139 448 31 ILE H H 9.141 . . 140 448 31 ILE C C 174.67 . . 141 448 31 ILE CA C 58.827 . . 142 448 31 ILE N N 122.02 . . 143 449 32 GLU H H 8.333 . . 144 449 32 GLU C C 175.09 . . 145 449 32 GLU CA C 54.312 . . 146 449 32 GLU CB C 30.000 . . 147 449 32 GLU N N 125.08 . . 148 450 33 ARG H H 8.556 . . 149 450 33 ARG C C 177.91 . . 150 450 33 ARG CA C 57.021 . . 151 450 33 ARG CB C 28.645 . . 152 450 33 ARG N N 119.25 . . 153 451 34 GLY H H 9.101 . . 154 451 34 GLY C C 173.66 . . 155 451 34 GLY CA C 44.202 . . 156 451 34 GLY N N 113.68 . . 157 452 35 GLN H H 7.847 . . 158 452 35 GLN C C 173.30 . . 159 452 35 GLN CA C 55.872 . . 160 452 35 GLN CB C 29.900 . . 161 452 35 GLN N N 118.54 . . 162 453 36 LEU H H 9.538 . . 163 453 36 LEU C C 175.08 . . 164 453 36 LEU CA C 53.000 . . 165 453 36 LEU CB C 42.316 . . 166 453 36 LEU N N 120.75 . . 167 454 37 LEU H H 9.053 . . 168 454 37 LEU C C 174.18 . . 169 454 37 LEU CA C 52.096 . . 170 454 37 LEU CB C 42.975 . . 171 454 37 LEU N N 129.85 . . 172 455 38 ALA H H 8.708 . . 173 455 38 ALA C C 174.93 . . 174 455 38 ALA CA C 49.058 . . 175 455 38 ALA CB C 20.314 . . 176 455 38 ALA N N 129.04 . . 177 456 39 VAL H H 9.039 . . 178 456 39 VAL C C 173.11 . . 179 456 39 VAL CA C 60.141 . . 180 456 39 VAL CB C 32.966 . . 181 456 39 VAL N N 123.40 . . 182 457 40 ALA H H 8.997 . . 183 457 40 ALA C C 175.73 . . 184 457 40 ALA CA C 49.058 . . 185 457 40 ALA CB C 23.249 . . 186 457 40 ALA N N 128.05 . . 187 458 41 GLY H H 8.183 . . 188 458 41 GLY C C 174.03 . . 189 458 41 GLY CA C 44.317 . . 190 458 41 GLY N N 105.59 . . 191 459 42 SER H H 9.305 . . 192 459 42 SER C C 173.98 . . 193 459 42 SER CA C 58.065 . . 194 459 42 SER N N 119.05 . . 195 460 43 THR H H 8.616 . . 196 460 43 THR CA C 63.121 . . 197 460 43 THR N N 117.12 . . 198 461 44 GLY H H 8.017 . . 199 461 44 GLY C C 174.41 . . 200 461 44 GLY CA C 44.776 . . 201 461 44 GLY N N 114.28 . . 202 462 45 ALA H H 8.111 . . 203 462 45 ALA C C 175.96 . . 204 462 45 ALA CA C 54.652 . . 205 462 45 ALA CB C 20.408 . . 206 462 45 ALA N N 122.43 . . 207 463 46 GLY H H 7.913 . . 208 463 46 GLY C C 173.48 . . 209 463 46 GLY CA C 44.239 . . 210 463 46 GLY N N 99.872 . . 211 464 47 LYS H H 9.128 . . 212 464 47 LYS C C 177.49 . . 213 464 47 LYS CA C 59.480 . . 214 464 47 LYS N N 122.77 . . 215 465 48 THR H H 9.392 . . 216 465 48 THR C C 177.16 . . 217 465 48 THR CA C 67.053 . . 218 465 48 THR N N 117.10 . . 219 466 49 SER H H 8.200 . . 220 466 49 SER C C 173.96 . . 221 466 49 SER CA C 64.296 . . 222 466 49 SER N N 118.83 . . 223 467 50 LEU H H 8.135 . . 224 467 50 LEU C C 178.40 . . 225 467 50 LEU CA C 58.528 . . 226 467 50 LEU N N 123.18 . . 227 468 51 LEU H H 7.345 . . 228 468 51 LEU C C 179.03 . . 229 468 51 LEU CA C 57.808 . . 230 468 51 LEU CB C 38.988 . . 231 468 51 LEU N N 117.62 . . 232 469 52 MET H H 8.681 . . 233 469 52 MET C C 178.81 . . 234 469 52 MET CA C 56.870 . . 235 469 52 MET N N 117.48 . . 236 470 53 MET H H 8.086 . . 237 470 53 MET C C 179.77 . . 238 470 53 MET CA C 57.799 . . 239 470 53 MET N N 120.34 . . 240 471 54 ILE H H 7.485 . . 241 471 54 ILE C C 175.68 . . 242 471 54 ILE CA C 64.729 . . 243 471 54 ILE N N 122.10 . . 244 472 55 MET H H 7.427 . . 245 472 55 MET C C 175.72 . . 246 472 55 MET CA C 55.767 . . 247 472 55 MET CB C 32.471 . . 248 472 55 MET CG C 31.772 . . 249 472 55 MET N N 113.19 . . 250 473 56 GLY H H 7.464 . . 251 473 56 GLY C C 174.05 . . 252 473 56 GLY CA C 44.736 . . 253 473 56 GLY N N 106.28 . . 254 474 57 GLU H H 7.862 . . 255 474 57 GLU C C 174.07 . . 256 474 57 GLU CA C 56.401 . . 257 474 57 GLU CG C 35.440 . . 258 474 57 GLU N N 118.34 . . 259 475 58 LEU H H 6.445 . . 260 475 58 LEU C C 174.04 . . 261 475 58 LEU CA C 52.521 . . 262 475 58 LEU CB C 42.091 . . 263 475 58 LEU CD1 C 24.500 . . 264 475 58 LEU N N 119.36 . . 265 476 59 GLU H H 8.620 . . 266 476 59 GLU C C 173.67 . . 267 476 59 GLU CA C 52.800 . . 268 476 59 GLU CB C 29.481 . . 269 476 59 GLU N N 127.08 . . 270 477 60 PRO C C 176.75 . . 271 477 60 PRO CA C 62.117 . . 272 477 60 PRO CB C 31.465 . . 273 478 61 SER H H 9.168 . . 274 478 61 SER C C 174.09 . . 275 478 61 SER CA C 59.611 . . 276 478 61 SER CB C 63.476 . . 277 478 61 SER N N 119.44 . . 278 479 62 GLU H H 7.807 . . 279 479 62 GLU C C 174.28 . . 280 479 62 GLU CA C 54.574 . . 281 479 62 GLU CB C 32.898 . . 282 479 62 GLU CG C 35.385 . . 283 479 62 GLU N N 119.46 . . 284 480 63 GLY H H 8.314 . . 285 480 63 GLY C C 173.48 . . 286 480 63 GLY CA C 44.349 . . 287 480 63 GLY N N 107.70 . . 288 481 64 LYS H H 8.231 . . 289 481 64 LYS C C 173.68 . . 290 481 64 LYS CA C 54.252 . . 291 481 64 LYS CB C 35.855 . . 292 481 64 LYS CG C 23.933 . . 293 481 64 LYS CD C 28.539 . . 294 481 64 LYS N N 116.50 . . 295 482 65 ILE H H 8.482 . . 296 482 65 ILE C C 174.72 . . 297 482 65 ILE CA C 58.760 . . 298 482 65 ILE CB C 39.834 . . 299 482 65 ILE N N 121.66 . . 300 483 66 LYS H H 8.941 . . 301 483 66 LYS C C 174.63 . . 302 483 66 LYS CA C 54.493 . . 303 483 66 LYS N N 126.84 . . 304 484 67 HIS H H 8.077 . . 305 484 67 HIS C C 173.71 . . 306 484 67 HIS CA C 55.701 . . 307 484 67 HIS N N 118.84 . . 308 485 68 SER H H 8.711 . . 309 485 68 SER C C 174.76 . . 310 485 68 SER CA C 57.874 . . 311 485 68 SER CB C 64.356 . . 312 485 68 SER N N 116.06 . . 313 486 69 GLY H H 8.949 . . 314 486 69 GLY C C 173.52 . . 315 486 69 GLY CA C 44.430 . . 316 486 69 GLY N N 111.89 . . 317 487 70 ARG H H 8.940 . . 318 487 70 ARG C C 176.06 . . 319 487 70 ARG CA C 55.218 . . 320 487 70 ARG CB C 29.784 . . 321 487 70 ARG N N 121.47 . . 322 488 71 ILE H H 8.696 . . 323 488 71 ILE C C 175.71 . . 324 488 71 ILE CA C 59.485 . . 325 488 71 ILE CB C 40.935 . . 326 488 71 ILE N N 125.45 . . 327 489 72 SER H H 8.100 . . 328 489 72 SER C C 172.40 . . 329 489 72 SER CA C 55.379 . . 330 489 72 SER CB C 63.989 . . 331 489 72 SER N N 119.29 . . 332 490 73 PHE H H 8.932 . . 333 490 73 PHE C C 173.36 . . 334 490 73 PHE CA C 54.252 . . 335 490 73 PHE CB C 42.158 . . 336 490 73 PHE N N 129.93 . . 337 491 74 CYS H H 8.813 . . 338 491 74 CYS C C 170.67 . . 339 491 74 CYS CA C 56.184 . . 340 491 74 CYS N N 130.22 . . 341 492 75 SER H H 7.991 . . 342 492 75 SER C C 173.43 . . 343 492 75 SER CA C 57.016 . . 344 492 75 SER N N 120.57 . . 345 499 82 PRO C C 176.30 . . 346 499 82 PRO CA C 62.834 . . 347 500 83 GLY H H 7.899 . . 348 500 83 GLY C C 172.77 . . 349 500 83 GLY CA C 43.290 . . 350 500 83 GLY N N 112.25 . . 351 501 84 THR H H 9.034 . . 352 501 84 THR C C 178.08 . . 353 501 84 THR CA C 60.401 . . 354 501 84 THR CB C 70.966 . . 355 501 84 THR N N 111.12 . . 356 502 85 ILE C C 176.31 . . 357 502 85 ILE CA C 66.971 . . 358 503 86 LYS H H 8.115 . . 359 503 86 LYS C C 178.43 . . 360 503 86 LYS CA C 59.733 . . 361 503 86 LYS N N 119.70 . . 362 504 87 GLU H H 8.188 . . 363 504 87 GLU C C 179.88 . . 364 504 87 GLU CA C 58.404 . . 365 504 87 GLU N N 116.46 . . 366 505 88 ASN H H 8.093 . . 367 505 88 ASN C C 175.67 . . 368 505 88 ASN CA C 57.296 . . 369 505 88 ASN N N 116.96 . . 370 506 89 ILE H H 7.761 . . 371 506 89 ILE C C 174.83 . . 372 506 89 ILE CA C 64.608 . . 373 506 89 ILE N N 118.51 . . 374 507 90 ILE H H 8.087 . . 375 507 90 ILE C C 176.09 . . 376 507 90 ILE CA C 61.875 . . 377 507 90 ILE N N 112.16 . . 378 508 91 PHE H H 7.549 . . 379 508 91 PHE CA C 58.773 . . 380 508 91 PHE N N 121.14 . . 381 509 92 GLY H H 8.346 . . 382 509 92 GLY C C 174.00 . . 383 509 92 GLY CA C 45.037 . . 384 509 92 GLY N N 108.56 . . 385 510 93 VAL H H 8.162 . . 386 510 93 VAL C C 175.14 . . 387 510 93 VAL CA C 60.392 . . 388 510 93 VAL CB C 32.260 . . 389 510 93 VAL CG2 C 21.430 . . 390 510 93 VAL N N 120.47 . . 391 511 94 SER H H 8.222 . . 392 511 94 SER C C 175.43 . . 393 511 94 SER CA C 58.842 . . 394 511 94 SER CB C 63.177 . . 395 511 94 SER N N 116.92 . . 396 512 95 TYR H H 9.175 . . 397 512 95 TYR C C 172.91 . . 398 512 95 TYR CA C 58.624 . . 399 512 95 TYR CB C 38.088 . . 400 512 95 TYR N N 126.71 . . 401 513 96 ASP H H 7.329 . . 402 513 96 ASP C C 174.28 . . 403 513 96 ASP CA C 52.219 . . 404 513 96 ASP CB C 42.751 . . 405 513 96 ASP N N 131.49 . . 406 514 97 GLU H H 8.702 . . 407 514 97 GLU C C 176.71 . . 408 514 97 GLU CA C 59.248 . . 409 514 97 GLU CB C 29.000 . . 410 514 97 GLU CG C 34.726 . . 411 514 97 GLU N N 126.73 . . 412 515 98 TYR H H 8.092 . . 413 515 98 TYR C C 179.09 . . 414 515 98 TYR CA C 60.741 . . 415 515 98 TYR CB C 36.816 . . 416 515 98 TYR N N 118.46 . . 417 516 99 ARG H H 8.479 . . 418 516 99 ARG C C 178.49 . . 419 516 99 ARG CA C 58.791 . . 420 516 99 ARG CB C 29.266 . . 421 516 99 ARG N N 122.91 . . 422 517 100 TYR H H 9.046 . . 423 517 100 TYR C C 178.49 . . 424 517 100 TYR CA C 61.776 . . 425 517 100 TYR CB C 38.353 . . 426 517 100 TYR N N 119.96 . . 427 518 101 ARG H H 8.591 . . 428 518 101 ARG C C 179.25 . . 429 518 101 ARG CA C 58.316 . . 430 518 101 ARG CB C 28.524 . . 431 518 101 ARG N N 116.63 . . 432 519 102 SER H H 7.925 . . 433 519 102 SER C C 176.59 . . 434 519 102 SER CA C 61.369 . . 435 519 102 SER CB C 62.223 . . 436 519 102 SER N N 114.89 . . 437 520 103 VAL H H 8.144 . . 438 520 103 VAL C C 177.08 . . 439 520 103 VAL CA C 66.272 . . 440 520 103 VAL CB C 30.630 . . 441 520 103 VAL N N 123.78 . . 442 521 104 ILE H H 8.197 . . 443 521 104 ILE C C 178.04 . . 444 521 104 ILE CA C 63.890 . . 445 521 104 ILE N N 118.85 . . 446 522 105 LYS H H 7.664 . . 447 522 105 LYS C C 180.11 . . 448 522 105 LYS CA C 58.625 . . 449 522 105 LYS CB C 31.465 . . 450 522 105 LYS CG C 24.160 . . 451 522 105 LYS N N 119.17 . . 452 523 106 ALA H H 7.987 . . 453 523 106 ALA C C 178.41 . . 454 523 106 ALA CA C 54.541 . . 455 523 106 ALA CB C 18.450 . . 456 523 106 ALA N N 121.69 . . 457 524 107 CYS H H 7.799 . . 458 524 107 CYS C C 171.23 . . 459 524 107 CYS CA C 59.952 . . 460 524 107 CYS N N 110.48 . . 461 525 108 GLN H H 7.760 . . 462 525 108 GLN C C 175.65 . . 463 525 108 GLN CA C 55.398 . . 464 525 108 GLN CB C 24.444 . . 465 525 108 GLN CG C 33.931 . . 466 525 108 GLN N N 112.17 . . 467 526 109 LEU H H 8.242 . . 468 526 109 LEU C C 177.10 . . 469 526 109 LEU CA C 54.194 . . 470 526 109 LEU N N 115.90 . . 471 527 110 GLU H H 7.850 . . 472 527 110 GLU C C 178.85 . . 473 527 110 GLU CA C 59.945 . . 474 527 110 GLU CB C 29.319 . . 475 527 110 GLU CG C 36.658 . . 476 527 110 GLU N N 120.98 . . 477 528 111 GLU H H 8.630 . . 478 528 111 GLU C C 178.60 . . 479 528 111 GLU CA C 58.536 . . 480 528 111 GLU CB C 27.942 . . 481 528 111 GLU N N 119.05 . . 482 529 112 ASP H H 7.876 . . 483 529 112 ASP C C 177.85 . . 484 529 112 ASP CA C 56.645 . . 485 529 112 ASP N N 118.34 . . 486 530 113 ILE H H 7.945 . . 487 530 113 ILE C C 176.91 . . 488 530 113 ILE CA C 64.520 . . 489 530 113 ILE N N 115.39 . . 490 531 114 SER H H 7.613 . . 491 531 114 SER C C 174.99 . . 492 531 114 SER CA C 60.169 . . 493 531 114 SER CB C 62.859 . . 494 531 114 SER N N 112.25 . . 495 532 115 LYS H H 7.073 . . 496 532 115 LYS C C 176.93 . . 497 532 115 LYS CA C 56.286 . . 498 532 115 LYS N N 119.05 . . 499 533 116 PHE H H 7.421 . . 500 533 116 PHE C C 178.03 . . 501 533 116 PHE CA C 55.665 . . 502 533 116 PHE CB C 39.200 . . 503 533 116 PHE N N 118.54 . . 504 536 119 LYS C C 175.03 . . 505 536 119 LYS CA C 55.889 . . 506 537 120 ASP H H 8.825 . . 507 537 120 ASP C C 174.69 . . 508 537 120 ASP CA C 53.620 . . 509 537 120 ASP N N 116.53 . . 510 538 121 ASN H H 8.295 . . 511 538 121 ASN C C 173.96 . . 512 538 121 ASN CA C 52.147 . . 513 538 121 ASN CB C 37.914 . . 514 538 121 ASN N N 115.29 . . 515 539 122 ILE H H 7.266 . . 516 539 122 ILE C C 172.87 . . 517 539 122 ILE CA C 60.159 . . 518 539 122 ILE N N 120.88 . . 519 540 123 VAL H H 7.719 . . 520 540 123 VAL C C 174.42 . . 521 540 123 VAL CA C 62.872 . . 522 540 123 VAL N N 124.68 . . 523 541 124 LEU H H 8.526 . . 524 541 124 LEU C C 177.23 . . 525 541 124 LEU CA C 52.695 . . 526 541 124 LEU CB C 41.691 . . 527 541 124 LEU N N 126.47 . . 528 542 125 GLY H H 8.354 . . 529 542 125 GLY C C 173.99 . . 530 542 125 GLY CA C 43.521 . . 531 542 125 GLY N N 108.19 . . 532 543 126 GLU H H 8.571 . . 533 543 126 GLU C C 177.72 . . 534 543 126 GLU CA C 57.207 . . 535 543 126 GLU CG C 35.520 . . 536 543 126 GLU N N 121.89 . . 537 544 127 GLY H H 8.826 . . 538 544 127 GLY C C 174.26 . . 539 544 127 GLY CA C 44.688 . . 540 544 127 GLY N N 113.17 . . 541 545 128 GLY H H 8.252 . . 542 545 128 GLY C C 174.20 . . 543 545 128 GLY CA C 44.600 . . 544 545 128 GLY N N 110.22 . . 545 548 131 LEU C C 176.95 . . 546 548 131 LEU CA C 52.888 . . 547 549 132 SER H H 9.035 . . 548 549 132 SER CA C 56.470 . . 549 549 132 SER N N 117.18 . . 550 550 133 GLY C C 176.75 . . 551 550 133 GLY CA C 46.816 . . 552 551 134 GLY H H 8.926 . . 553 551 134 GLY C C 176.93 . . 554 551 134 GLY CA C 46.588 . . 555 551 134 GLY N N 110.32 . . 556 552 135 GLN H H 7.748 . . 557 552 135 GLN C C 178.18 . . 558 552 135 GLN CA C 58.991 . . 559 552 135 GLN N N 121.99 . . 560 553 136 ARG H H 8.447 . . 561 553 136 ARG C C 178.43 . . 562 553 136 ARG CA C 59.861 . . 563 553 136 ARG N N 117.96 . . 564 554 137 ALA H H 8.231 . . 565 554 137 ALA C C 181.10 . . 566 554 137 ALA CA C 54.586 . . 567 554 137 ALA N N 121.67 . . 568 555 138 ARG H H 7.825 . . 569 555 138 ARG C C 177.76 . . 570 555 138 ARG CA C 60.556 . . 571 555 138 ARG N N 118.42 . . 572 556 139 ILE H H 8.207 . . 573 556 139 ILE C C 176.00 . . 574 556 139 ILE CA C 64.703 . . 575 556 139 ILE N N 119.75 . . 576 557 140 SER H H 7.942 . . 577 557 140 SER CA C 60.929 . . 578 557 140 SER N N 114.26 . . 579 559 142 ALA CA C 54.680 . . 580 559 142 ALA CB C 17.795 . . 581 560 143 ARG H H 8.206 . . 582 560 143 ARG C C 178.71 . . 583 560 143 ARG CA C 57.429 . . 584 560 143 ARG CB C 29.743 . . 585 560 143 ARG N N 117.55 . . 586 561 144 ALA H H 7.278 . . 587 561 144 ALA C C 180.33 . . 588 561 144 ALA CA C 53.444 . . 589 561 144 ALA CB C 18.022 . . 590 561 144 ALA N N 118.94 . . 591 562 145 VAL H H 8.378 . . 592 562 145 VAL C C 175.67 . . 593 562 145 VAL CA C 63.430 . . 594 562 145 VAL N N 114.77 . . 595 563 146 TYR H H 8.748 . . 596 563 146 TYR C C 176.78 . . 597 563 146 TYR CA C 61.536 . . 598 563 146 TYR CB C 37.700 . . 599 563 146 TYR N N 120.40 . . 600 564 147 LYS H H 6.813 . . 601 564 147 LYS C C 175.09 . . 602 564 147 LYS CA C 56.635 . . 603 564 147 LYS CB C 31.889 . . 604 564 147 LYS N N 118.65 . . 605 565 148 ASP H H 8.798 . . 606 565 148 ASP C C 173.36 . . 607 565 148 ASP CA C 54.239 . . 608 565 148 ASP CB C 40.102 . . 609 565 148 ASP N N 127.48 . . 610 566 149 ALA H H 7.826 . . 611 566 149 ALA C C 173.74 . . 612 566 149 ALA CA C 49.544 . . 613 566 149 ALA CB C 20.576 . . 614 566 149 ALA N N 127.58 . . 615 567 150 ASP H H 7.787 . . 616 567 150 ASP C C 174.72 . . 617 567 150 ASP CA C 55.044 . . 618 567 150 ASP N N 116.92 . . 619 568 151 LEU H H 7.540 . . 620 568 151 LEU C C 172.78 . . 621 568 151 LEU CA C 53.004 . . 622 568 151 LEU N N 120.47 . . 623 569 152 TYR H H 8.577 . . 624 569 152 TYR C C 173.60 . . 625 569 152 TYR CA C 56.388 . . 626 569 152 TYR N N 124.53 . . 627 570 153 LEU H H 9.152 . . 628 570 153 LEU C C 173.58 . . 629 570 153 LEU CA C 52.026 . . 630 570 153 LEU N N 123.32 . . 631 571 154 LEU H H 9.445 . . 632 571 154 LEU C C 172.97 . . 633 571 154 LEU CA C 52.283 . . 634 571 154 LEU CB C 41.720 . . 635 571 154 LEU N N 124.13 . . 636 572 155 ASP H H 8.522 . . 637 572 155 ASP C C 172.42 . . 638 572 155 ASP CA C 52.114 . . 639 572 155 ASP N N 126.57 . . 640 573 156 SER H H 7.282 . . 641 573 156 SER CA C 56.616 . . 642 573 156 SER N N 113.67 . . 643 577 160 TYR C C 175.36 . . 644 577 160 TYR CA C 58.902 . . 645 578 161 LEU H H 7.593 . . 646 578 161 LEU C C 176.73 . . 647 578 161 LEU CA C 53.257 . . 648 578 161 LEU CB C 41.204 . . 649 578 161 LEU N N 118.44 . . 650 579 162 ASP H H 8.226 . . 651 579 162 ASP C C 175.54 . . 652 579 162 ASP CA C 52.672 . . 653 579 162 ASP N N 120.47 . . 654 580 163 VAL H H 8.337 . . 655 580 163 VAL C C 178.03 . . 656 580 163 VAL CA C 64.953 . . 657 580 163 VAL CG2 C 20.408 . . 658 580 163 VAL N N 117.73 . . 659 581 164 LEU H H 8.069 . . 660 581 164 LEU C C 178.75 . . 661 581 164 LEU CA C 57.277 . . 662 581 164 LEU CB C 38.890 . . 663 581 164 LEU N N 121.79 . . 664 582 165 THR H H 8.046 . . 665 582 165 THR C C 175.93 . . 666 582 165 THR CA C 66.088 . . 667 582 165 THR N N 118.69 . . 668 583 166 GLU H H 8.476 . . 669 583 166 GLU C C 176.02 . . 670 583 166 GLU CA C 59.484 . . 671 583 166 GLU CB C 28.945 . . 672 583 166 GLU N N 120.98 . . 673 584 167 LYS H H 7.604 . . 674 584 167 LYS C C 178.78 . . 675 584 167 LYS CA C 59.156 . . 676 584 167 LYS CB C 31.700 . . 677 584 167 LYS CG C 23.900 . . 678 584 167 LYS N N 119.21 . . 679 585 168 GLU H H 7.989 . . 680 585 168 GLU C C 179.49 . . 681 585 168 GLU CA C 58.307 . . 682 585 168 GLU CB C 28.585 . . 683 585 168 GLU CG C 35.220 . . 684 585 168 GLU N N 117.95 . . 685 586 169 ILE H H 8.492 . . 686 586 169 ILE C C 179.08 . . 687 586 169 ILE CA C 64.081 . . 688 586 169 ILE CB C 37.102 . . 689 586 169 ILE CG2 C 17.750 . . 690 586 169 ILE N N 119.33 . . 691 587 170 PHE H H 9.178 . . 692 587 170 PHE C C 176.67 . . 693 587 170 PHE CA C 62.193 . . 694 587 170 PHE CB C 37.500 . . 695 587 170 PHE N N 124.66 . . 696 588 171 GLU H H 8.146 . . 697 588 171 GLU C C 177.85 . . 698 588 171 GLU CA C 59.156 . . 699 588 171 GLU CB C 28.585 . . 700 588 171 GLU CG C 35.694 . . 701 588 171 GLU N N 116.82 . . 702 589 172 SER H H 8.951 . . 703 589 172 SER C C 175.87 . . 704 589 172 SER CA C 61.372 . . 705 589 172 SER CB C 62.820 . . 706 589 172 SER N N 112.64 . . 707 590 173 CYS H H 9.191 . . 708 590 173 CYS C C 173.82 . . 709 590 173 CYS CA C 60.059 . . 710 590 173 CYS N N 121.64 . . 711 591 174 VAL H H 7.102 . . 712 591 174 VAL C C 176.18 . . 713 591 174 VAL CA C 65.994 . . 714 591 174 VAL N N 115.52 . . 715 592 175 CYS H H 7.297 . . 716 592 175 CYS C C 175.01 . . 717 592 175 CYS CA C 60.873 . . 718 592 175 CYS CB C 26.617 . . 719 592 175 CYS N N 112.36 . . 720 593 176 LYS H H 6.799 . . 721 593 176 LYS C C 177.39 . . 722 593 176 LYS CA C 58.009 . . 723 593 176 LYS CB C 31.730 . . 724 593 176 LYS CG C 24.386 . . 725 593 176 LYS N N 116.93 . . 726 594 177 LEU H H 7.916 . . 727 594 177 LEU C C 178.65 . . 728 594 177 LEU CA C 58.296 . . 729 594 177 LEU CB C 40.843 . . 730 594 177 LEU CG C 25.980 . . 731 594 177 LEU CD1 C 22.570 . . 732 594 177 LEU N N 122.20 . . 733 595 178 MET H H 7.134 . . 734 595 178 MET C C 174.16 . . 735 595 178 MET CA C 53.887 . . 736 595 178 MET CB C 32.313 . . 737 595 178 MET N N 111.44 . . 738 596 179 ALA H H 6.747 . . 739 596 179 ALA C C 177.15 . . 740 596 179 ALA CA C 54.191 . . 741 596 179 ALA CB C 18.363 . . 742 596 179 ALA N N 118.68 . . 743 597 180 ASN H H 8.497 . . 744 597 180 ASN C C 174.67 . . 745 597 180 ASN CA C 52.727 . . 746 597 180 ASN CB C 37.558 . . 747 597 180 ASN N N 110.72 . . 748 598 181 LYS H H 7.828 . . 749 598 181 LYS C C 175.77 . . 750 598 181 LYS CA C 52.086 . . 751 598 181 LYS CB C 33.637 . . 752 598 181 LYS N N 117.93 . . 753 599 182 THR H H 8.682 . . 754 599 182 THR C C 174.12 . . 755 599 182 THR CA C 63.359 . . 756 599 182 THR CB C 68.992 . . 757 599 182 THR N N 122.50 . . 758 600 183 ARG H H 9.297 . . 759 600 183 ARG C C 173.26 . . 760 600 183 ARG CA C 53.692 . . 761 600 183 ARG N N 126.77 . . 762 601 184 ILE H H 8.995 . . 763 601 184 ILE C C 172.95 . . 764 601 184 ILE CA C 59.965 . . 765 601 184 ILE CB C 38.194 . . 766 601 184 ILE N N 120.68 . . 767 602 185 LEU H H 9.169 . . 768 602 185 LEU C C 174.59 . . 769 602 185 LEU CA C 51.707 . . 770 602 185 LEU N N 129.00 . . 771 603 186 VAL H H 8.905 . . 772 603 186 VAL C C 175.05 . . 773 603 186 VAL CA C 61.109 . . 774 603 186 VAL CG2 C 21.318 . . 775 603 186 VAL N N 129.31 . . 776 604 187 THR H H 8.554 . . 777 604 187 THR C C 170.65 . . 778 604 187 THR CA C 58.812 . . 779 604 187 THR CB C 67.750 . . 780 604 187 THR CG2 C 19.727 . . 781 604 187 THR N N 121.90 . . 782 605 188 SER H H 8.108 . . 783 605 188 SER C C 173.66 . . 784 605 188 SER CA C 56.258 . . 785 605 188 SER CB C 64.555 . . 786 605 188 SER N N 117.63 . . 787 606 189 LYS H H 7.830 . . 788 606 189 LYS C C 177.36 . . 789 606 189 LYS CA C 54.287 . . 790 606 189 LYS CB C 29.850 . . 791 606 189 LYS N N 121.21 . . 792 607 190 MET H H 9.006 . . 793 607 190 MET C C 177.39 . . 794 607 190 MET CA C 57.743 . . 795 607 190 MET CB C 30.273 . . 796 607 190 MET CG C 31.658 . . 797 607 190 MET N N 127.48 . . 798 608 191 GLU H H 9.011 . . 799 608 191 GLU C C 177.70 . . 800 608 191 GLU CA C 58.545 . . 801 608 191 GLU CB C 28.259 . . 802 608 191 GLU N N 115.70 . . 803 609 192 HIS H H 6.798 . . 804 609 192 HIS C C 177.37 . . 805 609 192 HIS CA C 55.037 . . 806 609 192 HIS N N 116.61 . . 807 610 193 LEU H H 7.390 . . 808 610 193 LEU C C 177.71 . . 809 610 193 LEU CA C 57.777 . . 810 610 193 LEU N N 117.83 . . 811 611 194 LYS H H 7.379 . . 812 611 194 LYS C C 177.22 . . 813 611 194 LYS CA C 57.779 . . 814 611 194 LYS CB C 31.730 . . 815 611 194 LYS N N 114.07 . . 816 612 195 LYS H H 6.948 . . 817 612 195 LYS C C 175.53 . . 818 612 195 LYS CA C 54.236 . . 819 612 195 LYS CB C 32.207 . . 820 612 195 LYS CG C 24.727 . . 821 612 195 LYS N N 115.72 . . 822 613 196 ALA H H 7.353 . . 823 613 196 ALA C C 176.56 . . 824 613 196 ALA CA C 51.717 . . 825 613 196 ALA CB C 19.252 . . 826 613 196 ALA N N 122.10 . . 827 614 197 ASP H H 9.007 . . 828 614 197 ASP C C 176.85 . . 829 614 197 ASP CA C 57.230 . . 830 614 197 ASP CB C 42.168 . . 831 614 197 ASP N N 120.78 . . 832 615 198 LYS H H 8.002 . . 833 615 198 LYS C C 173.09 . . 834 615 198 LYS CA C 52.966 . . 835 615 198 LYS CB C 37.982 . . 836 615 198 LYS N N 114.38 . . 837 616 199 ILE H H 9.206 . . 838 616 199 ILE C C 172.63 . . 839 616 199 ILE CA C 59.184 . . 840 616 199 ILE N N 119.76 . . 841 617 200 LEU H H 9.081 . . 842 617 200 LEU C C 174.28 . . 843 617 200 LEU CA C 52.664 . . 844 617 200 LEU N N 126.47 . . 845 618 201 ILE H H 9.570 . . 846 618 201 ILE C C 175.66 . . 847 618 201 ILE CA C 58.792 . . 848 618 201 ILE CG2 C 16.328 . . 849 618 201 ILE N N 124.64 . . 850 619 202 LEU H H 8.927 . . 851 619 202 LEU C C 176.43 . . 852 619 202 LEU CA C 52.259 . . 853 619 202 LEU N N 127.48 . . 854 620 203 HIS H H 9.275 . . 855 620 203 HIS C C 174.75 . . 856 620 203 HIS CA C 56.375 . . 857 620 203 HIS CB C 32.048 . . 858 620 203 HIS N N 119.08 . . 859 621 204 GLU H H 9.579 . . 860 621 204 GLU C C 175.98 . . 861 621 204 GLU CA C 56.445 . . 862 621 204 GLU CB C 26.450 . . 863 621 204 GLU N N 126.73 . . 864 622 205 GLY H H 7.863 . . 865 622 205 GLY CA C 46.442 . . 866 622 205 GLY N N 105.20 . . 867 623 206 SER H H 7.981 . . 868 623 206 SER C C 173.43 . . 869 623 206 SER CA C 56.615 . . 870 623 206 SER CB C 65.200 . . 871 623 206 SER N N 113.95 . . 872 624 207 SER H H 9.285 . . 873 624 207 SER C C 174.10 . . 874 624 207 SER CA C 57.000 . . 875 624 207 SER CB C 62.011 . . 876 624 207 SER N N 116.45 . . 877 625 208 TYR H H 9.390 . . 878 625 208 TYR C C 175.52 . . 879 625 208 TYR CA C 58.787 . . 880 625 208 TYR CB C 38.989 . . 881 625 208 TYR N N 132.94 . . 882 626 209 PHE H H 7.877 . . 883 626 209 PHE C C 171.42 . . 884 626 209 PHE CA C 58.096 . . 885 626 209 PHE CB C 42.445 . . 886 626 209 PHE N N 116.62 . . 887 627 210 TYR H H 7.257 . . 888 627 210 TYR C C 173.54 . . 889 627 210 TYR CA C 54.817 . . 890 627 210 TYR CB C 40.030 . . 891 627 210 TYR N N 127.53 . . 892 628 211 GLY H H 7.950 . . 893 628 211 GLY C C 171.51 . . 894 628 211 GLY CA C 44.985 . . 895 628 211 GLY N N 115.37 . . 896 629 212 THR H H 8.877 . . 897 629 212 THR C C 175.34 . . 898 629 212 THR CA C 59.810 . . 899 629 212 THR CB C 70.409 . . 900 629 212 THR CG2 C 21.387 . . 901 629 212 THR N N 113.01 . . 902 630 213 PHE H H 9.419 . . 903 630 213 PHE C C 176.69 . . 904 630 213 PHE CA C 61.971 . . 905 630 213 PHE CB C 38.110 . . 906 630 213 PHE N N 121.71 . . 907 631 214 SER H H 8.612 . . 908 631 214 SER C C 176.99 . . 909 631 214 SER CA C 60.924 . . 910 631 214 SER CB C 61.897 . . 911 631 214 SER N N 112.80 . . 912 632 215 GLU H H 7.442 . . 913 632 215 GLU C C 178.32 . . 914 632 215 GLU CA C 58.148 . . 915 632 215 GLU CB C 28.789 . . 916 632 215 GLU N N 120.98 . . 917 633 216 LEU H H 7.898 . . 918 633 216 LEU C C 177.62 . . 919 633 216 LEU CA C 56.921 . . 920 633 216 LEU CB C 39.158 . . 921 633 216 LEU N N 123.49 . . 922 634 217 GLN H H 7.682 . . 923 634 217 GLN C C 176.82 . . 924 634 217 GLN CA C 57.260 . . 925 634 217 GLN CB C 27.942 . . 926 634 217 GLN N N 114.78 . . 927 635 218 ASN H H 7.245 . . 928 635 218 ASN C C 175.84 . . 929 635 218 ASN CA C 54.062 . . 930 635 218 ASN CB C 38.724 . . 931 635 218 ASN N N 114.48 . . 932 636 219 LEU H H 7.799 . . 933 636 219 LEU C C 177.27 . . 934 636 219 LEU CA C 55.651 . . 935 636 219 LEU CB C 42.221 . . 936 636 219 LEU CD1 C 23.704 . . 937 636 219 LEU N N 119.54 . . 938 637 220 GLN H H 8.261 . . 939 637 220 GLN C C 173.01 . . 940 637 220 GLN CA C 52.795 . . 941 637 220 GLN CB C 27.624 . . 942 637 220 GLN N N 117.53 . . 943 638 221 PRO CA C 63.963 . . 944 638 221 PRO CB C 30.831 . . 945 638 221 PRO CG C 26.704 . . 946 638 221 PRO CD C 49.000 . . 947 639 222 ASP H H 8.349 . . 948 639 222 ASP C C 176.66 . . 949 639 222 ASP CA C 53.312 . . 950 639 222 ASP CB C 39.614 . . 951 639 222 ASP N N 117.09 . . 952 640 223 PHE H H 7.981 . . 953 640 223 PHE C C 176.16 . . 954 640 223 PHE CA C 59.353 . . 955 640 223 PHE CB C 38.115 . . 956 640 223 PHE N N 120.60 . . 957 641 224 SER H H 7.850 . . 958 641 224 SER C C 175.43 . . 959 641 224 SER CA C 59.511 . . 960 641 224 SER N N 116.23 . . 961 642 225 SER H H 8.018 . . 962 642 225 SER C C 175.34 . . 963 642 225 SER CA C 59.666 . . 964 642 225 SER CB C 62.692 . . 965 642 225 SER N N 117.10 . . 966 643 226 LYS H H 7.785 . . 967 643 226 LYS C C 176.67 . . 968 643 226 LYS CA C 56.103 . . 969 643 226 LYS CB C 31.436 . . 970 643 226 LYS CG C 24.182 . . 971 643 226 LYS CD C 27.916 . . 972 643 226 LYS N N 120.98 . . 973 644 227 LEU H H 7.556 . . 974 644 227 LEU C C 176.60 . . 975 644 227 LEU CA C 54.735 . . 976 644 227 LEU CB C 41.261 . . 977 644 227 LEU N N 118.71 . . 978 645 228 MET H H 7.778 . . 979 645 228 MET C C 175.33 . . 980 645 228 MET CA C 54.735 . . 981 645 228 MET CB C 32.618 . . 982 645 228 MET CG C 31.000 . . 983 645 228 MET N N 117.16 . . 984 646 229 GLY H H 7.811 . . 985 646 229 GLY C C 178.64 . . 986 646 229 GLY CA C 45.637 . . 987 646 229 GLY N N 114.88 . . stop_ save_