data_5632 ####################### # Entry information # ####################### save_entry_information _Saveframe_category entry_information _Entry_title ; Solution structure of the p2b hairpin from human telomerase RNA ; _BMRB_accession_number 5632 _BMRB_flat_file_name bmr5632.str _Entry_type original _Submission_date 2002-12-19 _Accession_date 2002-12-19 _Entry_origination author _NMR_STAR_version 2.1.1 _Experimental_method NMR _Details . loop_ _Author_ordinal _Author_family_name _Author_given_name _Author_middle_initials _Author_family_title 1 Theimer C. A. . 2 Finger L. D. . 3 Trantirek L. . . 4 Feigon J. . . stop_ loop_ _Saveframe_category_type _Saveframe_category_type_count assigned_chemical_shifts 1 stop_ loop_ _Data_type _Data_type_count "1H chemical shifts" 262 "13C chemical shifts" 201 "15N chemical shifts" 25 stop_ loop_ _Revision_date _Revision_keyword _Revision_author _Revision_detail 2004-03-07 original author . stop_ _Original_release_date 2004-03-07 save_ ############################# # Citation for this entry # ############################# save_entry_citation _Saveframe_category entry_citation _Citation_full . _Citation_title ; Mutations Linked to Dyskeratosis congenita Cause Changes in the Structural Equilibrium in Telomerase RNA ; _Citation_status published _Citation_type journal _CAS_abstract_code . _MEDLINE_UI_code 22426914 _PubMed_ID 12525685 loop_ _Author_ordinal _Author_family_name _Author_given_name _Author_middle_initials _Author_family_title 1 Theimer C. A. . 2 Finger L. D. . 3 Trantirek L. . . 4 Feigon J. . . stop_ _Journal_abbreviation 'Proc. Natl. Acad. Sci. U. S. A.' _Journal_volume 100 _Journal_issue 2 _Journal_CSD . _Book_chapter_title . _Book_volume . _Book_series . _Book_ISBN . _Conference_state_province . _Conference_abstract_number . _Page_first 449 _Page_last 454 _Year 2003 _Details . loop_ _Keyword hairpin 'narrow minor groove' NMR pentaloop RNA telomerase 'U-C base pair' 'U tracts' 'U-U base pair' stop_ save_ ################################## # Molecular system description # ################################## save_system_hTR_RNA _Saveframe_category molecular_system _Mol_system_name 'telomerase RNA p2b hairpin' _Abbreviation_common 'hTR RNA' _Enzyme_commission_number . loop_ _Mol_system_component_name _Mol_label 'telomerase RNA p2b hairpin' $hTR_RNA stop_ _System_molecular_weight . _System_physical_state native _System_oligomer_state monomer _System_paramagnetic no _System_thiol_state 'not present' _Database_query_date . _Details . save_ ######################## # Monomeric polymers # ######################## save_hTR_RNA _Saveframe_category monomeric_polymer _Mol_type polymer _Mol_polymer_class RNA _Name_common 'human telomerase RNA' _Abbreviation_common 'hTR RNA' _Molecular_mass 9900 _Mol_thiol_state 'not present' _Details . ############################## # Polymer residue sequence # ############################## _Residue_count 30 _Mol_residue_sequence ; GGGCUGUUUUUCUCGCUGAC UUUCAGCCCC ; loop_ _Residue_seq_code _Residue_author_seq_code _Residue_label 1 93 G 2 94 G 3 95 G 4 96 C 5 97 U 6 98 G 7 99 U 8 100 U 9 101 U 10 102 U 11 103 U 12 104 C 13 105 U 14 106 C 15 107 G 16 108 C 17 109 U 18 110 G 19 111 A 20 112 C 21 113 U 22 114 U 23 115 U 24 116 C 25 117 A 26 118 G 27 119 C 28 120 C 29 121 C 30 122 C stop_ _Sequence_homology_query_date . _Sequence_homology_query_revised_last_date . save_ #################### # Natural source # #################### save_natural_source _Saveframe_category natural_source loop_ _Mol_label _Organism_name_common _NCBI_taxonomy_ID _Superkingdom _Kingdom _Genus _Species $hTR_RNA Human 9606 Eukaryota Metazoa Homo sapiens stop_ save_ ######################### # Experimental source # ######################### save_experimental_source _Saveframe_category experimental_source loop_ _Mol_label _Production_method _Host_organism_name_common _Genus _Species _Strain _Vector_name $hTR_RNA 'enzymatic semisynthesis' . . . . . stop_ save_ ##################################### # Sample contents and methodology # ##################################### ######################## # Sample description # ######################## save_sample_1 _Saveframe_category sample _Sample_type solution _Details . loop_ _Mol_label _Concentration_value _Concentration_value_units _Isotopic_labeling $hTR_RNA 1 mM . 'Na phosphate' 10 mM . KCl 200 mM . NaN3 0.2 % . EDTA 50 uM . H2O 95 % . D2O 5 % . stop_ save_ save_sample_2 _Saveframe_category sample _Sample_type solution _Details . loop_ _Mol_label _Concentration_value _Concentration_value_units _Isotopic_labeling $hTR_RNA 1 mM '[U-100% 13C; U-100% 15N]' 'Na phosphate' 10 mM . KCl 200 mM . NaN3 0.2 % . EDTA 50 uM . H2O 95 % . D2O 100 % . stop_ save_ save_sample_3 _Saveframe_category sample _Sample_type solution _Details . loop_ _Mol_label _Concentration_value _Concentration_value_units _Isotopic_labeling $hTR_RNA 1 mM '[U-100% 13C; U-100% 15N]' stop_ save_ ############################ # Computer software used # ############################ save_XWINNMR _Saveframe_category software _Name xwinnmr _Version 2.6 loop_ _Task processing stop_ _Details Bruker save_ save_AURELIA _Saveframe_category software _Name AURELIA _Version 3.108 loop_ _Task 'data analysis' stop_ _Details Bruker save_ save_X-PLOR _Saveframe_category software _Name X-PLOR _Version 3.851 loop_ _Task refinement 'structure solution' stop_ _Details Brunger save_ ######################### # Experimental detail # ######################### ################################## # NMR Spectrometer definitions # ################################## save_NMR_spectrometer _Saveframe_category NMR_spectrometer _Manufacturer Bruker _Model DRX _Field_strength 500 _Details . save_ ############################# # NMR applied experiments # ############################# save_2D_NOESY_1 _Saveframe_category NMR_applied_experiment _Experiment_name '2D NOESY' _Sample_label . save_ save_DQF-COSY_2 _Saveframe_category NMR_applied_experiment _Experiment_name DQF-COSY _Sample_label . save_ save_3D_13C-separated_NOESY_3 _Saveframe_category NMR_applied_experiment _Experiment_name '3D 13C-separated NOESY' _Sample_label . save_ save_3D_13C_NOESY-HMQC_4 _Saveframe_category NMR_applied_experiment _Experiment_name '3D 13C NOESY-HMQC' _Sample_label . save_ save_NMR_spec_expt__0_1 _Saveframe_category NMR_applied_experiment _Experiment_name '2D NOESY' _BMRB_pulse_sequence_accession_number . _Details . save_ save_NMR_spec_expt__0_2 _Saveframe_category NMR_applied_experiment _Experiment_name DQF-COSY _BMRB_pulse_sequence_accession_number . _Details . save_ save_NMR_spec_expt__0_3 _Saveframe_category NMR_applied_experiment _Experiment_name '3D 13C-separated NOESY' _BMRB_pulse_sequence_accession_number . _Details . save_ save_NMR_spec_expt__0_4 _Saveframe_category NMR_applied_experiment _Experiment_name '3D 13C NOESY-HMQC' _BMRB_pulse_sequence_accession_number . _Details . save_ ####################### # Sample conditions # ####################### save_sample_cond_1 _Saveframe_category sample_conditions _Details . loop_ _Variable_type _Variable_value _Variable_value_error _Variable_value_units 'ionic strength' 200 . mM pH 6.3 0.2 n/a pressure 1 . atm temperature 278 1 K stop_ save_ save_sample_cond_2 _Saveframe_category sample_conditions _Details . loop_ _Variable_type _Variable_value _Variable_value_error _Variable_value_units 'ionic strength' 200 . mM pH 6.3 0.2 n/a pressure 1 . atm temperature 293 1 K stop_ save_ #################### # NMR parameters # #################### ############################## # Assigned chemical shifts # ############################## ################################ # Chemical shift referencing # ################################ save_chemical_shift_reference _Saveframe_category chemical_shift_reference _Details . loop_ _Mol_common_name _Atom_type _Atom_isotope_number _Atom_group _Chem_shift_units _Chem_shift_value _Reference_method _Reference_type _External_reference_sample_geometry _External_reference_location _External_reference_axis _Indirect_shift_ratio DSS C 13 'methyl protons' ppm 0.0 . indirect . . . 0.251449530 H20 H 1 protons ppm . internal direct . internal . 1.0 DSS N 15 'methyl protons' ppm 0.0 . indirect . . . 0.101329118 stop_ save_ ################################### # Assigned chemical shift lists # ################################### ################################################################### # Chemical Shift Ambiguity Index Value Definitions # # # # The values other than 1 are used for those atoms with different # # chemical shifts that cannot be assigned to stereospecific atoms # # or to specific residues or chains. # # # # Index Value Definition # # # # 1 Unique (including isolated methyl protons, # # geminal atoms, and geminal methyl # # groups with identical chemical shifts) # # (e.g. ILE HD11, HD12, HD13 protons) # # 2 Ambiguity of geminal atoms or geminal methyl # # proton groups (e.g. ASP HB2 and HB3 # # protons, LEU CD1 and CD2 carbons, or # # LEU HD11, HD12, HD13 and HD21, HD22, # # HD23 methyl protons) # # 3 Aromatic atoms on opposite sides of # # symmetrical rings (e.g. TYR HE1 and HE2 # # protons) # # 4 Intraresidue ambiguities (e.g. LYS HG and # # HD protons or TRP HZ2 and HZ3 protons) # # 5 Interresidue ambiguities (LYS 12 vs. LYS 27) # # 6 Intermolecular ambiguities (e.g. ASP 31 CA # # in monomer 1 and ASP 31 CA in monomer 2 # # of an asymmetrical homodimer, duplex # # DNA assignments, or other assignments # # that may apply to atoms in one or more # # molecule in the molecular assembly) # # 9 Ambiguous, specific ambiguity not defined # # # ################################################################### save_chemical_shift_set_1 _Saveframe_category assigned_chemical_shifts _Details . loop_ _Sample_label $sample_1 $sample_2 $sample_3 stop_ _Sample_conditions_label $sample_cond_1 _Chem_shift_reference_set_label $chemical_shift_reference _Mol_system_component_name 'telomerase RNA p2b hairpin' _Text_data_format . _Text_data . loop_ _Atom_shift_assign_ID _Residue_author_seq_code _Residue_seq_code _Residue_label _Atom_name _Atom_type _Chem_shift_value _Chem_shift_value_error _Chem_shift_ambiguity_code 1 . 1 G H1 H 12.758 . 1 2 . 1 G H8 H 8.196 . 1 3 . 1 G C8 C 136.444 . 1 4 . 1 G N1 N 147.050 . 1 5 . 1 G H1' H 5.927 . 1 6 . 1 G H2' H 4.908 . 1 7 . 1 G H3' H 4.621 . 1 8 . 1 G H4' H 4.607 . 1 9 . 1 G H5' H 4.527 . 2 10 . 1 G H5'' H 4.306 . 2 11 . 1 G C1' C 90.236 . 1 12 . 1 G C2' C 72.577 . 1 13 . 1 G C3' C 70.123 . 1 14 . 1 G C4' C 80.565 . 1 15 . 1 G C5' C 64.279 . 1 16 . 2 G H1 H 12.744 . 1 17 . 2 G H8 H 7.541 . 1 18 . 2 G C8 C 134.229 . 1 19 . 2 G N1 N 147.364 . 1 20 . 2 G H1' H 5.936 . 1 21 . 2 G H2' H 4.741 . 1 22 . 2 G H3' H 4.706 . 1 23 . 2 G H4' H 4.552 . 1 24 . 2 G H5' H 4.556 . 2 25 . 2 G H5'' H 4.209 . 2 26 . 2 G C1' C 90.313 . 1 27 . 2 G C2' C 73.082 . 1 28 . 2 G C3' C 71.422 . 1 29 . 2 G C4' C 79.603 . 1 30 . 2 G C5' C 62.684 . 1 31 . 3 G H1 H 13.225 . 1 32 . 3 G H8 H 7.250 . 1 33 . 3 G C8 C 133.550 . 1 34 . 3 G N1 N 148.333 . 1 35 . 3 G H1' H 5.816 . 1 36 . 3 G H2' H 4.592 . 1 37 . 3 G H3' H 4.457 . 1 38 . 3 G H4' H 4.531 . 1 39 . 3 G H5' H 4.505 . 2 40 . 3 G H5'' H 4.094 . 2 41 . 3 G C1' C 90.477 . 1 42 . 3 G C2' C 72.723 . 1 43 . 3 G C3' C 70.380 . 1 44 . 3 G C4' C 79.584 . 1 45 . 3 G C5' C 63.028 . 1 46 . 4 C H41 H 8.648 . 2 47 . 4 C H42 H 6.968 . 2 48 . 4 C H5 H 5.233 . 1 49 . 4 C H6 H 7.686 . 1 50 . 4 C C5 C 95.700 . 1 51 . 4 C C6 C 138.632 . 1 52 . 4 C N4 N 98.496 . 1 53 . 4 C H1' H 5.562 . 1 54 . 4 C H2' H 4.349 . 1 55 . 4 C H3' H 4.598 . 1 56 . 4 C H4' H 4.321 . 1 57 . 4 C H5' H 4.564 . 2 58 . 4 C H5'' H 4.115 . 2 59 . 4 C C1' C 91.333 . 1 60 . 4 C C2' C 73.326 . 1 61 . 4 C C3' C 69.818 . 1 62 . 4 C C4' C 80.401 . 1 63 . 4 C C5' C 61.841 . 1 64 . 5 U H3 H 13.249 . 1 65 . 5 U H5 H 5.462 . 1 66 . 5 U H6 H 7.901 . 1 67 . 5 U C2 C 150.04 . 1 68 . 5 U C4 C 166.98 . 1 69 . 5 U C5 C 101.373 . 1 70 . 5 U C6 C 139.213 . 1 71 . 5 U N3 N 160.936 . 1 72 . 5 U H1' H 5.601 . 1 73 . 5 U H2' H 4.743 . 1 74 . 5 U H3' H 4.605 . 1 75 . 5 U H4' H 4.454 . 1 76 . 5 U H5' H 4.436 . 2 77 . 5 U H5'' H 4.105 . 2 78 . 5 U C1' C 90.862 . 1 79 . 5 U C2' C 72.944 . 1 80 . 5 U C3' C 69.845 . 1 81 . 5 U C4' C 79.562 . 1 82 . 5 U C5' C 63.105 . 1 83 . 6 G H1 H 12.832 . 1 84 . 6 G H21 H 8.276 . 2 85 . 6 G H22 H 5.923 . 2 86 . 6 G H8 H 7.631 . 1 87 . 6 G C8 C 133.439 . 1 88 . 6 G N1 N 146.896 . 1 89 . 6 G N2 N 74.535 . 1 90 . 6 G H1' H 5.810 . 1 91 . 6 G H2' H 4.456 . 1 92 . 6 G H3' H 4.319 . 1 93 . 6 G H4' H 4.399 . 1 94 . 6 G H5' H 4.474 . 2 95 . 6 G H5'' H 4.160 . 2 96 . 6 G C1' C 90.469 . 1 97 . 6 G C2' C 70.380 . 1 98 . 6 G C3' C 70.438 . 1 99 . 6 G C4' C 79.746 . 1 100 . 6 G C5' C 63.578 . 1 101 . 7 U H3 H 11.363 . 1 102 . 7 U H5 H 5.364 . 1 103 . 7 U H6 H 7.603 . 1 104 . 7 U C2 C 151.57 . 1 105 . 7 U C4 C 164.02 . 1 106 . 7 U C5 C 101.445 . 1 107 . 7 U C6 C 137.996 . 1 108 . 7 U N3 N 158.118 . 1 109 . 7 U H1' H 5.372 . 1 110 . 7 U H2' H 4.201 . 1 111 . 7 U H3' H 4.430 . 1 112 . 7 U H4' H 4.412 . 1 113 . 7 U H5' H 4.470 . 2 114 . 7 U H5'' H 4.075 . 2 115 . 7 U C1' C 91.169 . 1 116 . 7 U C2' C 72.987 . 1 117 . 7 U C3' C 69.154 . 1 118 . 7 U C4' C 79.966 . 1 119 . 7 U C5' C 60.938 . 1 120 . 8 U H3 H 11.477 . 1 121 . 8 U H5 H 5.694 . 1 122 . 8 U H6 H 7.958 . 1 123 . 8 U C2 C 150.96 . 1 124 . 8 U C4 C 165.35 . 1 125 . 8 U C6 C 140.422 . 1 126 . 8 U N3 N 157.038 . 1 127 . 8 U H1' H 5.507 . 1 128 . 8 U H2' H 4.314 . 1 129 . 8 U H3' H 4.485 . 1 130 . 8 U H4' H 4.410 . 1 131 . 8 U H5' H 4.515 . 2 132 . 8 U H5'' H 4.080 . 2 133 . 8 U C1' C 90.723 . 1 134 . 8 U C2' C 73.176 . 1 135 . 8 U C3' C 69.806 . 1 136 . 8 U C4' C 79.877 . 1 137 . 8 U C5' C 61.671 . 1 138 . 9 U H3 H 11.712 . 1 139 . 9 U H5 H 5.619 . 1 140 . 9 U H6 H 7.860 . 1 141 . 9 U C2 C 150.48 . 1 142 . 9 U C4 C 166.37 . 1 143 . 9 U C6 C 140.994 . 1 144 . 9 U N3 N 157.332 . 1 145 . 9 U H1' H 5.640 . 1 146 . 9 U H2' H 4.352 . 1 147 . 9 U H3' H 4.429 . 1 148 . 9 U H4' H 4.399 . 1 149 . 9 U H5' H 4.601 . 2 150 . 9 U H5'' H 4.123 . 2 151 . 9 U C1' C 91.858 . 1 152 . 9 U C2' C 73.151 . 1 153 . 9 U C3' C 69.702 . 1 154 . 9 U C4' C 79.670 . 1 155 . 9 U C5' C 61.629 . 1 156 . 10 U H5 H 5.644 . 1 157 . 10 U H6 H 8.028 . 1 158 . 10 U C6 C 139.917 . 1 159 . 10 U H1' H 5.828 . 1 160 . 10 U H2' H 4.188 . 1 161 . 10 U H3' H 4.638 . 1 162 . 10 U H4' H 4.392 . 1 163 . 10 U C1' C 91.298 . 1 164 . 10 U C2' C 72.890 . 1 165 . 10 U C3' C 69.640 . 1 166 . 10 U C4' C 79.751 . 1 167 . 11 U H3 H 14.755 . 1 168 . 11 U H5 H 5.730 . 1 169 . 11 U H6 H 8.125 . 1 170 . 11 U C6 C 140.635 . 1 171 . 11 U N3 N 163.457 . 1 172 . 11 U H1' H 5.844 . 1 173 . 11 U H2' H 4.609 . 1 174 . 11 U H3' H 4.627 . 1 175 . 11 U H4' H 4.440 . 1 176 . 11 U H5' H 4.505 . 2 177 . 11 U H5'' H 4.141 . 2 178 . 11 U C1' C 89.959 . 1 179 . 11 U C2' C 72.835 . 1 180 . 11 U C3' C 70.492 . 1 181 . 11 U C4' C 79.696 . 1 182 . 11 U C5' C 62.070 . 1 183 . 12 C H41 H 8.343 . 2 184 . 12 C H42 H 6.985 . 2 185 . 12 C H5 H 5.659 . 1 186 . 12 C H6 H 7.717 . 1 187 . 12 C C5 C 95.781 . 1 188 . 12 C C6 C 139.432 . 1 189 . 12 C N4 N 97.390 . 1 190 . 12 C H1' H 5.669 . 1 191 . 12 C H2' H 4.502 . 1 192 . 12 C H3' H 4.216 . 1 193 . 12 C H4' H 4.502 . 1 194 . 12 C H5' H 4.443 . 2 195 . 12 C H5'' H 4.110 . 2 196 . 12 C C1' C 91.699 . 1 197 . 12 C C2' C 73.248 . 1 198 . 12 C C3' C 70.679 . 1 199 . 12 C C4' C 80.049 . 1 200 . 12 C C5' C 62.151 . 1 201 . 13 U H5 H 5.629 . 1 202 . 13 U H6 H 7.732 . 1 203 . 13 U H1' H 5.605 . 1 204 . 13 U H2' H 4.413 . 1 205 . 13 U H3' H 4.437 . 1 206 . 13 U H4' H 4.333 . 1 207 . 13 U H5' H 4.431 . 2 208 . 13 U H5'' H 4.116 . 2 209 . 13 U C1' C 91.118 . 1 210 . 13 U C2' C 72.869 . 1 211 . 13 U C3' C 70.099 . 1 212 . 13 U C4' C 80.362 . 1 213 . 13 U C5' C 61.901 . 1 214 . 14 C H5 H 5.743 . 1 215 . 14 C H6 H 7.803 . 1 216 . 14 C C5 C 96.053 . 1 217 . 14 C C6 C 140.210 . 1 218 . 14 C H1' H 5.491 . 1 219 . 14 C H2' H 4.270 . 1 220 . 14 C H3' H 4.421 . 1 221 . 14 C H4' H 4.154 . 1 222 . 14 C H5' H 4.199 . 2 223 . 14 C H5'' H 3.977 . 2 224 . 14 C C1' C 90.127 . 1 225 . 14 C C2' C 73.281 . 1 226 . 14 C C3' C 71.664 . 1 227 . 14 C C4' C 80.477 . 1 228 . 14 C C5' C 62.739 . 1 229 . 15 G H21 H 6.351 . 2 230 . 15 G H22 H 5.937 . 2 231 . 15 G H8 H 7.872 . 1 232 . 15 G C8 C 137.088 . 1 233 . 15 G N2 N 72.361 . 1 234 . 15 G H1' H 5.683 . 1 235 . 15 G H2' H 3.925 . 1 236 . 15 G H3' H 4.146 . 1 237 . 15 G H4' H 4.050 . 1 238 . 15 G H5' H 4.379 . 2 239 . 15 G H5'' H 4.029 . 2 240 . 15 G C1' C 90.338 . 1 241 . 15 G C2' C 74.996 . 1 242 . 15 G C3' C 67.257 . 1 243 . 15 G C4' C 81.160 . 1 244 . 15 G C5' C 62.387 . 1 245 . 16 C H5 H 5.675 . 1 246 . 16 C H6 H 7.708 . 1 247 . 16 C C5 C 95.671 . 1 248 . 16 C C6 C 140.764 . 1 249 . 16 C H1' H 5.962 . 1 250 . 16 C H2' H 4.362 . 1 251 . 16 C H3' H 4.657 . 1 252 . 16 C H4' H 4.418 . 1 253 . 16 C H5' H 4.292 . 2 254 . 16 C H5'' H 4.132 . 2 255 . 16 C C1' C 88.852 . 1 256 . 16 C C2' C 73.616 . 1 257 . 16 C C3' C 74.229 . 1 258 . 16 C C4' C 82.095 . 1 259 . 16 C C5' C 64.579 . 1 260 . 17 U H5 H 5.869 . 1 261 . 17 U H6 H 7.861 . 1 262 . 17 U C5 C 102.640 . 1 263 . 17 U C6 C 140.997 . 1 264 . 17 U H1' H 5.795 . 1 265 . 17 U H2' H 4.564 . 1 266 . 17 U H3' H 4.526 . 1 267 . 17 U H4' H 4.508 . 1 268 . 17 U H5' H 4.306 . 2 269 . 17 U H5'' H 4.217 . 2 270 . 17 U C1' C 89.474 . 1 271 . 17 U C2' C 72.979 . 1 272 . 17 U C3' C 72.950 . 1 273 . 17 U C4' C 81.781 . 1 274 . 17 U C5' C 65.146 . 1 275 . 18 G H1 H 12.372 . 1 276 . 18 G H8 H 7.869 . 1 277 . 18 G C8 C 137.035 . 1 278 . 18 G N1 N 146.896 . 1 279 . 18 G H1' H 5.724 . 1 280 . 18 G H2' H 4.774 . 1 281 . 18 G H3' H 4.553 . 1 282 . 18 G H4' H 4.487 . 1 283 . 18 G H5' H 4.558 . 2 284 . 18 G H5'' H 4.132 . 2 285 . 18 G C1' C 89.946 . 1 286 . 18 G C2' C 72.898 . 1 287 . 18 G C3' C 70.190 . 1 288 . 18 G C4' C 79.366 . 1 289 . 18 G C5' C 62.347 . 1 290 . 19 A H2 H 7.919 . 1 291 . 19 A H61 H 8.150 . 2 292 . 19 A H62 H 6.788 . 2 293 . 19 A H8 H 7.878 . 1 294 . 19 A C2 C 151.242 . 1 295 . 19 A C8 C 135.220 . 1 296 . 19 A N6 N 83.401 . 1 297 . 19 A H1' H 6.081 . 1 298 . 19 A H2' H 4.674 . 1 299 . 19 A H3' H 4.434 . 1 300 . 19 A H4' H 4.587 . 1 301 . 19 A H5' H 4.528 . 2 302 . 19 A H5'' H 4.200 . 2 303 . 19 A C1' C 90.630 . 1 304 . 19 A C2' C 72.996 . 1 305 . 19 A C3' C 70.396 . 1 306 . 19 A C4' C 79.826 . 1 307 . 19 A C5' C 63.553 . 1 308 . 20 C H41 H 7.729 . 2 309 . 20 C H42 H 6.402 . 2 310 . 20 C H5 H 4.922 . 1 311 . 20 C H6 H 6.991 . 1 312 . 20 C C5 C 93.998 . 1 313 . 20 C C6 C 137.551 . 1 314 . 20 C N4 N 94.796 . 1 315 . 20 C H1' H 5.327 . 1 316 . 20 C H2' H 4.460 . 1 317 . 20 C H3' H 4.156 . 1 318 . 20 C H4' H 4.377 . 1 319 . 20 C H5' H 4.475 . 2 320 . 20 C H5'' H 4.027 . 2 321 . 20 C C1' C 91.190 . 1 322 . 20 C C2' C 72.755 . 1 323 . 20 C C3' C 69.412 . 1 324 . 20 C C4' C 79.146 . 1 325 . 20 C C5' C 61.452 . 1 326 . 21 U H3 H 11.156 . 1 327 . 21 U H5 H 5.624 . 1 328 . 21 U H6 H 7.873 . 1 329 . 21 U C2 C 151.89 . 1 330 . 21 U C4 C 164.38 . 1 331 . 21 U C6 C 138.713 . 1 332 . 21 U N3 N 157.061 . 1 333 . 21 U H1' H 5.645 . 1 334 . 21 U H2' H 4.496 . 1 335 . 21 U H3' H 4.357 . 1 336 . 21 U H4' H 4.143 . 1 337 . 21 U H5' H 4.147 . 2 338 . 21 U H5'' H 3.986 . 2 339 . 21 U C1' C 90.927 . 1 340 . 21 U C2' C 72.716 . 1 341 . 21 U C3' C 70.174 . 1 342 . 21 U C4' C 80.074 . 1 343 . 21 U C5' C 64.419 . 1 344 . 22 U H3 H 11.352 . 1 345 . 22 U H5 H 5.722 . 1 346 . 22 U H6 H 7.956 . 1 347 . 22 U C2 C 151.51 . 1 348 . 22 U C4 C 165.20 . 1 349 . 22 U C6 C 140.424 . 1 350 . 22 U N3 N 157.034 . 1 351 . 22 U H1' H 5.560 . 1 352 . 22 U H2' H 4.278 . 1 353 . 22 U H3' H 4.435 . 1 354 . 22 U H4' H 4.472 . 1 355 . 22 U H5' H 4.463 . 2 356 . 22 U H5'' H 4.089 . 2 357 . 22 U C1' C 91.270 . 1 358 . 22 U C2' C 73.077 . 1 359 . 22 U C3' C 70.523 . 1 360 . 22 U C4' C 80.073 . 1 361 . 22 U C5' C 62.987 . 1 362 . 23 U H3 H 10.655 . 1 363 . 23 U H5 H 5.718 . 1 364 . 23 U H6 H 7.947 . 1 365 . 23 U C2 C 150.01 . 1 366 . 23 U C4 C 166.50 . 1 367 . 23 U C6 C 141.193 . 1 368 . 23 U N3 N 156.356 . 1 369 . 23 U H1' H 5.584 . 1 370 . 23 U H2' H 4.407 . 1 371 . 23 U H3' H 4.463 . 1 372 . 23 U H4' H 4.417 . 1 373 . 23 U H5' H 4.548 . 2 374 . 23 U H5'' H 4.131 . 2 375 . 23 U C1' C 91.643 . 1 376 . 23 U C2' C 72.601 . 1 377 . 23 U C3' C 69.764 . 1 378 . 23 U C4' C 79.906 . 1 379 . 23 U C5' C 61.952 . 1 380 . 24 C H41 H 8.422 . 2 381 . 24 C H42 H 7.367 . 2 382 . 24 C H5 H 5.937 . 1 383 . 24 C H6 H 8.105 . 1 384 . 24 C C5 C 95.893 . 1 385 . 24 C C6 C 139.727 . 1 386 . 24 C N4 N 98.554 . 1 387 . 24 C H1' H 5.690 . 1 388 . 24 C H2' H 4.652 . 1 389 . 24 C H3' H 4.607 . 1 390 . 24 C H4' H 4.379 . 1 391 . 24 C H5' H 4.158 . 2 392 . 24 C H5'' H 4.006 . 2 393 . 24 C C1' C 88.799 . 1 394 . 24 C C2' C 72.509 . 1 395 . 24 C C3' C 73.667 . 1 396 . 24 C C4' C 82.176 . 1 397 . 24 C C5' C 64.475 . 1 398 . 25 A H2 H 7.138 . 1 399 . 25 A H61 H 8.233 . 2 400 . 25 A H62 H 7.170 . 2 401 . 25 A H8 H 8.154 . 1 402 . 25 A C2 C 150.428 . 1 403 . 25 A C8 C 137.457 . 1 404 . 25 A N6 N 82.401 . 1 405 . 25 A H1' H 5.975 . 1 406 . 25 A H2' H 4.714 . 1 407 . 25 A H3' H 4.705 . 1 408 . 25 A H4' H 4.592 . 1 409 . 25 A H5' H 4.540 . 2 410 . 25 A H5'' H 4.284 . 2 411 . 25 A C1' C 90.356 . 1 412 . 25 A C2' C 73.114 . 1 413 . 25 A C3' C 70.771 . 1 414 . 25 A C4' C 79.807 . 1 415 . 25 A C5' C 63.910 . 1 416 . 26 G H1 H 13.478 . 1 417 . 26 G H8 H 7.463 . 1 418 . 26 G C8 C 133.458 . 1 419 . 26 G N1 N 147.853 . 1 420 . 26 G H1' H 5.731 . 1 421 . 26 G H2' H 4.424 . 1 422 . 26 G H3' H 4.614 . 1 423 . 26 G H4' H 4.536 . 1 424 . 26 G H5' H 4.431 . 2 425 . 26 G H5'' H 4.219 . 2 426 . 26 G C1' C 89.792 . 1 427 . 26 G C2' C 72.779 . 1 428 . 26 G C3' C 71.608 . 1 429 . 26 G C4' C 80.365 . 1 430 . 26 G C5' C 64.412 . 1 431 . 27 C H41 H 8.633 . 2 432 . 27 C H42 H 6.892 . 2 433 . 27 C H5 H 5.219 . 1 434 . 27 C H6 H 7.709 . 1 435 . 27 C C5 C 94.643 . 1 436 . 27 C N4 N 99.030 . 1 437 . 27 C H1' H 5.534 . 1 438 . 27 C H2' H 4.343 . 1 439 . 27 C H3' H 4.463 . 1 440 . 27 C H4' H 4.431 . 1 441 . 27 C H5' H 4.543 . 2 442 . 27 C H5'' H 4.075 . 2 443 . 27 C C1' C 91.195 . 1 444 . 27 C C2' C 72.975 . 1 445 . 27 C C3' C 69.445 . 1 446 . 27 C C4' C 79.311 . 1 447 . 27 C C5' C 61.571 . 1 448 . 28 C H41 H 8.615 . 2 449 . 28 C H42 H 6.882 . 2 450 . 28 C H5 H 5.496 . 1 451 . 28 C H6 H 7.822 . 1 452 . 28 C C5 C 95.269 . 1 453 . 28 C C6 C 138.896 . 1 454 . 28 C N4 N 98.458 . 1 455 . 28 C H1' H 5.542 . 1 456 . 28 C H2' H 4.416 . 1 457 . 28 C H3' H 4.442 . 1 458 . 28 C C1' C 91.488 . 1 459 . 28 C C2' C 72.855 . 1 460 . 28 C C3' C 69.885 . 1 461 . 29 C H41 H 8.421 . 2 462 . 29 C H42 H 7.032 . 2 463 . 29 C H5 H 5.482 . 1 464 . 29 C H6 H 7.721 . 1 465 . 29 C C5 C 95.265 . 1 466 . 29 C N4 N 97.924 . 1 467 . 29 C H1' H 5.570 . 1 468 . 29 C H2' H 4.412 . 1 469 . 29 C H3' H 4.738 . 1 470 . 29 C H4' H 4.400 . 1 471 . 29 C H5' H 4.425 . 2 472 . 29 C H5'' H 4.103 . 2 473 . 29 C C1' C 91.402 . 1 474 . 29 C C2' C 72.739 . 1 475 . 29 C C3' C 72.851 . 1 476 . 29 C C4' C 79.525 . 1 477 . 29 C C5' C 61.932 . 1 478 . 30 C H5 H 5.644 . 1 479 . 30 C H6 H 7.737 . 1 480 . 30 C C5 C 95.341 . 1 481 . 30 C H1' H 5.668 . 1 482 . 30 C H2' H 4.648 . 1 483 . 30 C H3' H 4.577 . 1 484 . 30 C H4' H 4.143 . 1 485 . 30 C C1' C 90.282 . 1 486 . 30 C C2' C 74.184 . 1 487 . 30 C C3' C 73.160 . 1 488 . 30 C C4' C 81.165 . 1 stop_ save_